Details for Patent: 7,332,472
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Which drugs does patent 7,332,472 protect, and when does it expire?
Patent 7,332,472 protects LUPKYNIS and is included in one NDA.
This patent has one hundred and sixty-three patent family members in thirty-four countries.
Summary for Patent: 7,332,472
| Title: | Cyclosporine analogue mixtures and their use as immunomodulating agents |
| Abstract: | The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives. Embodiments of the present invention are directed toward cis and trans-isomers of cyclosporin A analogs referred to as ISA.sub.TX247, and derivatives thereof. Mixtures of ISA.sub.TX247 isomers exhibit a combination of enhanced potency and reduced toxicity over the naturally occurring and presently known cyclosporins. ISA.sub.TX247 isomers and alkylated, arylated, and deuterated derivatives are synthesized by stereoselective pathways where the particular conditions of a reaction determine the degree of stereoselectivity. The ratio of isomers in a mixture may range from about 10 to 90 percent by weight of the (E)-isomer to about 90 to 10 percent by weight of the (Z)-isomer, based on the total weight of the mixture. |
| Inventor(s): | Naicker; Selvaraj (Edmonton, CA), Yatscoff; Randall W. (Edmonton, CA), Foster; Robert T. (Edmonton, CA) |
| Assignee: | Isotechnika Inc. (Edmonton, CA) |
| Application Number: | 11/118,830 |
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Patent Claim Types: see list of patent claims | Use; Composition; Formulation; Compound; Delivery; Dosage form; |
Drugs Protected by US Patent 7,332,472
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aurinia | LUPKYNIS | voclosporin | CAPSULE;ORAL | 213716-001 | Jan 22, 2021 | RX | Yes | Yes | ⤷ Try a Trial | ⤷ Try a Trial | Y | Y | TREATMENT OF PATIENTS WITH ACTIVE LUPUS NEPHRITIS | ⤷ Try a Trial | ||
| >Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
International Family Members for US Patent 7,332,472
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
|---|---|---|---|---|---|
| Argentina | 036852 | ⤷ Try a Trial | |||
| Argentina | 036853 | ⤷ Try a Trial | |||
| Austria | 332917 | ⤷ Try a Trial | |||
| Austria | 401339 | ⤷ Try a Trial | |||
| Austria | 425178 | ⤷ Try a Trial | |||
| Austria | 437629 | ⤷ Try a Trial | |||
| >Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |
