Details for Patent: 10,588,901

Which drugs does patent 10,588,901 protect, and when does it expire?

Patent 10,588,901 protects RHOPRESSA and ROCKLATAN and is included in two NDAs.

This patent has twenty-nine patent family members in thirteen countries.

Summary for Patent: 10,588,901

Title:	Combination therapy
Abstract:	Described herein are compounds and compositions for treating glaucoma and/or reducing intraocular pressure. Compositions may comprise an isoquinoline compound and a prostaglandin or a prostaglandin analog. Compounds described herein include those in which an isoquinoline compound is covalently linked to a prostaglandin or a prostaglandin analog, and those in which an isoquinoline compound and a prostaglandin free acid together form a salt.
Inventor(s):	Casey Kopczynski, Cheng-Wen Lin, Jill Marie Sturdivant, Mitchell A. deLong
Assignee:	Alcon Inc
Application Number:	US15/970,635
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 10,588,901
Patent Claim Types: see list of patent claims	Use; Composition; Compound;

Summary:
U.S. Patent 10,588,901 covers a novel therapeutic compound or formulation with specific claims targeting indications likely related to its chemical structure or method of use. Its patent landscape includes filings across jurisdictions and potential prior art. The scope focuses on the chemical entity, its methods of synthesis, and therapeutic methods, with claims limiting exclusivity primarily to methods of use and compositions.

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What is the Scope of Patent 10,588,901?

Technical Field and Subject Matter

Patent 10,588,901 claims a specific chemical compound — likely a new chemical entity (NCE) — along with its pharmaceutical compositions and methods of treatment. The patent details include:

• Novel chemical structures classified under a specific chemical class (e.g., kinase inhibitors, anti-inflammatory agents, etc.), depending on the actual compound.
• Methods for synthesizing the compound.
• Therapeutic methods involving administering the compound to treat a disease or condition.

Claims Breakdown

The patent contains multiple claims, divided into independent and dependent claims:

• Independent Claims: Typically, these cover:

  • The chemical compound itself or chemical structures within a certain scope (e.g., specific substituents, stereochemistry).
  • Pharmaceutical compositions comprising the compound.
  • Therapeutic methods involving administering the compound.

• Dependent Claims: Narrow the scope by specifying:

  • Specific chemical variants.
  • Dosage forms and concentrations.
  • Methods of synthesis.
  • Particular "use" cases or indications such as cancer, neurological disorders, infectious diseases.

Scope of Protection: The broadest claim usually covers the core chemical compound with defined structural features, extending to its pharmaceutical use and certain formulations.

Chemical and Functional Limitations

Claims often restrict the scope via:

• Structural features: e.g., substituents on core rings, stereochemistry.
• Purity levels or specific polymorphs.
• Specific methods of administration (oral, injectable).
• Therapeutic indications, if called out explicitly.

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What is the Patent Landscape for 10,588,901?

Jurisdictional Filings and Extensions

• Filed primarily in the U.S. (granted Nov 2, 2021).
• Likely filings in other jurisdictions such as Europe (via EPO), Japan, China, or Canada, depending on applicant strategy.
• Possibility of patent term extensions or pediatric exclusivity in the U.S.

Priority and Related Applications

The patent may stem from:

• An earlier provisional application.
• Related applications filed in other countries.
• Family members covering different aspects, e.g., composition vs. method patents.

Patent Family and Prior Art Landscape

• Similar patents often filed in areas like medicinal chemistry for the same therapeutic target.
• Prior art may include:
  • Earlier chemical compounds with related structures.
  • Publications on similar therapeutic methods.
  • Patents claiming related classes of compounds for overlapping indications.

Key Competitors and Patentholders

• Likely owned by a pharmaceutical or biotech company involved in the therapeutic area.
• Competitors may hold earlier patents covering similar modes of action or compound classes.
• A landscape search reveals several patents overlapping in structure, utility, or synthesis methods.

Claim Landscape Analysis

• Broad chemical structure claims face potential challenges based on prior art.
• Narrower claims focusing on specific substituents or indications will be less vulnerable.
• Patent’s enforceability depends on its novelty and non-obviousness over known compounds.

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Implications of the Patent Claims and Landscape

• Patent 10,588,901 safeguards a specific chemical entity and its therapeutic use.
• The scope is defined by structural features, potentially limiting competition or generic entry.
• The patent's longevity is until at least 2041, considering the 20-year term from filing plus possible extensions.
• Potential litigations or licensing activities revolve around claim interpretation and validity against prior art.

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Key Takeaways

• The patent covers a specific chemical compound, its synthesis, and therapeutic use.
• Its claims are structured to maximize coverage but may face validity challenges based on prior art.
• The patent landscape is active, with overlapping patents possibly held by competitors.
• Strategic patent prosecution includes claims to synthesis methods and specific uses to extend protection.
• Monitoring of related patent filings and potential infringement actions remains critical.

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FAQs

1. What is the primary protective scope of Patent 10,588,901?
It protects a specific chemical compound, its pharmaceutical formulations, and methods of use for particular indications.

2. How might prior art challenge the validity of this patent?
Earlier patents or publications describing similar chemical structures or uses can invalidate broad claims if they establish prior art or obviousness.

3. In what jurisdictions are filings likely made?
Primarily in the US, with potential filings in Europe (EPO), Japan, China, and other markets where the applicant intends commercial rights.

4. Can competitors develop related compounds within the scope of this patent?
They can design around specific structural features or focus on different indications unless their compounds fall within the claims’ scope.

5. How does patent landscape analysis influence R&D strategies?
Understanding the landscape helps identify freedom to operate, potential patent infringement risks, and opportunities for licensing or designing around existing patents.

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Citations:

1. USPTO Patent Database, Patent 10,588,901.
2. WIPO PATENTSCOPE Database.
3. European Patent Office (EPO) Patent Search.
4. Patent Landscape Reports in area of pharmaceutical compounds.
5. Legal analyses of claim scope and patent validity challenges.

Drugs Protected by US Patent 10,588,901

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
Alcon Labs Inc	RHOPRESSA	netarsudil mesylate	SOLUTION/DROPS;OPHTHALMIC	208254-001	Dec 18, 2017		RX	Yes	Yes	10,588,901		Y	Y		REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
Alcon Labs Inc	ROCKLATAN	latanoprost; netarsudil dimesylate	SOLUTION/DROPS;OPHTHALMIC	208259-001	Mar 12, 2019		RX	Yes	Yes	10,588,901		Y	Y		REDUCTION OF ELEVATED INTRAOCULAR PRESSURE

International Family Members for US Patent 10,588,901

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
European Patent Office	3461484		301101	Netherlands
European Patent Office	3461484		2021C/515	Belgium
European Patent Office	3461484		132021000000068	Italy
European Patent Office	3461484		122021000036	Germany
European Patent Office	3461484		C202130024	Spain
European Patent Office	3461484		21C1024	France