DrugPatentWatch Database Preview

Calcifediol - Generic Drug Details

« Back to Dashboard

What are the generic sources for calcifediol and what is the scope of calcifediol freedom to operate?

Calcifediol is the generic ingredient in two branded drugs marketed by Opko Ireland Global and Organon Usa Inc, and is included in two NDAs. There are twelve patents protecting this compound. Additional information is available in the individual branded drug profile pages.

Calcifediol has one hundred and thirteen patent family members in thirty-three countries.

There are two drug master file entries for calcifediol. One supplier is listed for this compound.

Summary for calcifediol

International Patents:	113
US Patents:	12
Tradenames:	2
Applicants:	2
NDAs:	2
Drug Master File Entries:	2
Suppliers / Packagers:	1
Bulk Api Vendors:	148
Clinical Trials:	17
Patent Applications:	2,474
Formulation / Manufacturing:	see details
DailyMed Link:	calcifediol at DailyMed

Pharmacology for calcifediol

Drug Class

Vitamin D3 Analog

Medical Subject Heading (MeSH) Categories for calcifediol

Bone Density Conservation Agents

Vitamins

Synonyms for calcifediol

(?R,1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-?,?,?,7a-tetramethyl-1H-indene-1-pentanol

(|AR,1R,3aS,4E,7aR)-Octahydro-4-[(2Z)-2-[(5R)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-|A,|A,|A,7a-tetramethyl-H-indene-1-pentanol

(1R,3Z)-3-[(2E)-2-[(1R,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol

(1S,3E)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol

(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R)-5-hydroxy-1,5-dimethyl-hexyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexanol

(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol

(1S,3Z)-3-[(2E)-2-[(1R,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol

(1S)-3-[2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol

(3|A,5Z,7E)-9,10-Seco-cholesta-5,7,10(19)-triene-3,25-diol

(3|A,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3,25-diol

(3b,5Z,7E)- 9,10-Secocholesta-5,7,10(19)-triene-3,25-diol

(3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol

(3E)-3-[(2E)-2-[1-(6-hydroxy-6-methylheptan-2-yl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol

(3S,5Z,14beta,17alpha)-9,10-secocholesta-5,7,10-triene-3,25-diol

(3S,5Z,7E)-9,10-seco-5,7,10(19)-cholestatriene-3,25-diol

(3S,5Z,7E)-9,10-secocholesta-5,7,10-triene-3,25-diol

(3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol

(5E,7E)-9,10-Secocholesta-5,7,10(19)-triene-3beta,25-diol

(5E,7Z)-(3S)-9,10-seco-5,7,10(19)-cholestatriene-3,25-diol

(5Z,7E)-(3R)-9,10-seco-5,7,10(19)-cholestatriene-3,25-diol

(5Z,7E)-(3S)-9,10-seco-5,7,10(19)-cholestatriene-3,25-diol

(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol

(5Z,7E)-9,10-Seco-5,7,10(19)-cholestatrien-3beta,25-diol

(5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3.beta.,25-diol #

(R,Z)-3-(2-((1R,3aS,7aR,E)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexan-1-ol

(S,E)-3-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexanol

(S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)-4-methylenecyclohexanol

(S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexanol

(S,Z)-3-(2-((1R,3aS,7aR,E)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexan-1-ol

1233749-00-2

1384584-62-6

19356-17-3

25-(OH)Vitamin D3

25-HCC

25-Hydroxy D3

25-Hydroxy vitamin D

25-Hydroxy vitamin D3

25-Hydroxy-3-epivitamin D3

25-hydroxy-cholecalciferol

25-Hydroxycholecalciferol

25-Hydroxycholecalciferol monohydrate

25-Hydroxycholecalciferol solution

25-Hydroxycholecalciferol, >=98% (HPLC)

25-Hydroxycholecalciferol, 5-trans-

25-Hydroxycholescalciferol

25-Hydroxyvitamin D

25-hydroxyvitamin D3

25-hydroxyvitamin D3 / 25-hydroxycholecalciferol / calcidiol

25-Hydroxyvitamin D3 monohydrate

25-Hydroxyvitamin D3 monohydrate, >=99.0% (HPLC)

25-Hydroxyvitamin D3 solution

25-Hydroxyvitamin D3 solution, 100 mug/mL in ethanol, 98% (CP)

25-Hydroxyvitamin D3 solution, 100 mug/mL in ethanol, ampule of 1 mL, certified reference material

25-Hydroxyvitamin D3 solution, 5 mug/mL in ethanol, 98% (CP)

25-Hydroxyvitamin D3 solution, 5 mug/mL in ethanol, ampule of 1 mL, certified reference material

25-Hydroxyvitamin D3 solution, 50 mug/mL in ethanol, 98% (CP)

25(OH)D3

25631-40-7

3-[2-[1-(5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexanol

3-[2-[1-(6-hydroxy-6-methylheptan-2-yl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol

3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL

3-epi-25-Hydroxy Vitamin D3

3-Epi-25-Hydroxyvitamin D3

3-epi-25-Hydroxyvitamin D3 solution, 100 mug/mL in ethanol, 98% (CP)

3-epi-25-Hydroxyvitamin D3 solution, 50 mug/mL in ethanol, 98% (CP)

3-epi-25-Hydroxyvitamin D3 solution, 50 mug/mL in ethanol, certified reference material

3-epi-25-Hydroxyvitamin D3, 98% (CP)

356C173

36149-00-5

5,6-cis-25-Hydroxy Vitamin D3

5,6-cis-25-Hydroxyvitamin D3

5,6-trans-25-Hydroxy vitamin D3

5,6-trans-25-Hydroxycholescalciferol

5,6-trans-25-Hydroxyvitamin D3

5,6-trans-9,10-Seco-5,7,10(19)-cholestatrien-3beta,25-diol

63283-36-3

64719-49-9

73809-05-9

78782-98-6

9,10-Secocholesta-5,7,10(19)-triene-1,25-diol, (3.beta,.5Z,7E)-

9,10-Secocholesta-5,7,10(19)-triene-3,25-diol, (3.beta.,5Z,7E)-

9,10-Secocholesta-5,7,10(19)-triene-3,25-diol, (3beta,5E,7E)-

9,10-Secocholesta-5,7,10(19)-triene-3,25-diol, (3beta,5Z,7E)-

9,10-Secocholesta-5,7,10(19)-triene-3.beta.,25-diol

9,10-Secocholesta-5,7,10(19)-triene-3b,25-diol

9,10-Secocholesta-5,7,10(19)-triene-3beta,25-diol

AB01275461_02

AB01275461-01

AB2000120

AC1L1BT0

AC1L4YCK

AC1NQX1D

AC1NR2WF

AC1NS422

AC1O5GOQ

AC1O6T7Q

ACT06833

AJ-62415

AK115143

AKOS005146518

AKOS015840003

AKOS015960730

AKOS015965097

AKOS016010097

AKOS032945268

AKOS032960352

AN-015

B91135EC-8937-4D8B-A533-CCD82F33C1B0

BC219279

BCP01929

BCP9000472

BCPP000306

Bio1_000100

Bio1_000589

Bio1_001078

Bio2_000131

Bio2_000611

BML2-E02

BRD-A78971512-001-01-5

BRD-K77175907-001-01-5

BSPBio_001411

C01561

Calcidiol

Calcidiol;Didrogyl;Hidroferol

Calcifediol [INN]

Calcifediol anhydrous

Calcifediol, European Pharmacopoeia (EP) Reference Standard

Calcifediol, United States Pharmacopeia (USP) Reference Standard

Calcifediolum

Calcifediolum [INN-Latin]

Calcifidiol

Calderol

Calderol (TN)

CAS-19356-17-3

CBiol_001814

CHEBI:125445

CHEBI:17933

CHEBI:94743

CHEMBL1040

CHEMBL3250186

Cholecalciferol, 25-hydroxy-

CS-0800

CS-M3650

CTK8E9743

CTK8F5046

DB00146

Dedrogyl

Delakmin

Didrogyl

DM100

DSSTox_CID_2721

DSSTox_GSID_22721

DSSTox_RID_76699

DTXSID0022721

DTXSID30274318

EINECS 242-990-9

FT-0082670

FT-0604695

FT-0650575

FT-0670229

GTPL6921

Hidroferol

HMS1361G13

HMS1791G13

HMS1989G13

HMS2089L21

HMS3402G13

HY-32351

Hy-D

IDI1_033881

JWUBBDSIWDLEOM-DTOXIADCSA-N

JWUBBDSIWDLEOM-XHQRYOPUSA-N

KBio2_000131

KBio2_002699

KBio2_005267

KBio3_000261

KBio3_000262

KBioGR_000131

KBioSS_000131

KS-00000XN4

LMST03020246

LMST03020646

LMST03020655

LS-187713

MFCD00867077

MolPort-003-927-271

MolPort-027-835-871

NCGC00161326-01

NCGC00161326-04

NCGC00179206-01

PubChem18824

Rayaldee

Ro 8-8892

Rovimix Hy-D

Ryaldee

s1469

SC-76996

SCHEMBL10018928

SCHEMBL15263247

SCHEMBL16136766

SCHEMBL1836573

SCHEMBL2734120

SCHEMBL3296

SCHEMBL3333455

SCHEMBL7901515

SN331791VY

Spectrum5_001931

SR-05000001468

SR-05000001468-1

ST2407990

SW219602-1

T0WXW8F54E

Tox21_111987

U-32070E

UNII-SN331791VY

UNII-T0WXW8F54E

VDY

Vitamin D, 25-hydroxy-

Vitamin D3 25-hydroxy monohydrate

W-201718

W-5159

ZINC12484926

ZINC13525982

ZINC4474414

ZX-AFC002925

US Patents and Regulatory Information for calcifediol

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Opko Ireland Global	RAYALDEE	calcifediol	CAPSULE, EXTENDED RELEASE;ORAL	208010-001	Jun 17, 2016		RX	Yes	Yes
Opko Ireland Global	RAYALDEE	calcifediol	CAPSULE, EXTENDED RELEASE;ORAL	208010-001	Jun 17, 2016		RX	Yes	Yes
Opko Ireland Global	RAYALDEE	calcifediol	CAPSULE, EXTENDED RELEASE;ORAL	208010-001	Jun 17, 2016		RX	Yes	Yes

Expired US Patents for calcifediol

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	Patent No.	Patent Expiration
Organon Usa Inc	CALDEROL	calcifediol	CAPSULE;ORAL	018312-002	Approved Prior to Jan 1, 1982
Organon Usa Inc	CALDEROL	calcifediol	CAPSULE;ORAL	018312-001	Approved Prior to Jan 1, 1982
Organon Usa Inc	CALDEROL	calcifediol	CAPSULE;ORAL	018312-002	Approved Prior to Jan 1, 1982

International Patents for calcifediol

Country	Patent Number	Estimated Expiration
South Africa	200200109
Poland	198332
Austria	345113