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Generated: September 16, 2019

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Patent: 9,850,473

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Summary for Patent: 9,850,473
Title:Transglycosylation activity of glycosynthase mutants of an endo-beta-N-acetylglucosaminidase (endo-D) from Streptococcus pneumoniae
Abstract: The present invention provides for recombinant Endo-D and selected mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sugar chain is added to a core fucosylated or nonfucosylated GlcNAc-protein acceptor by transglycosylation. Such recombinant Endo-D and selected mutants are useful for efficient glycosylation remodeling of IgG1-Fc domain.
Inventor(s): Wang; Lai-Xi (Ellicott City, MD)
Assignee: University of Maryland, Baltimore (Baltimore, MA)
Application Number:14/878,089
Patent Claims:see list of patent claims

Details for Patent 9,850,473

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Centocor Inc REOPRO abciximab INJECTABLE; INJECTION 103575 001 1994-12-22   Try a Free Trial University of Maryland, Baltimore (Baltimore, MA) 2031-03-03 RX search
Genentech RITUXAN rituximab VIAL 103705 001 1997-11-26   Try a Free Trial University of Maryland, Baltimore (Baltimore, MA) 2031-03-03 RX search
Novartis SIMULECT basiliximab VIAL; SINGLE-USE 103764 001 1998-05-12   Try a Free Trial University of Maryland, Baltimore (Baltimore, MA) 2031-03-03 RX search
Novartis SIMULECT basiliximab VIAL; SINGLE-USE 103764 002 1998-05-12   Try a Free Trial University of Maryland, Baltimore (Baltimore, MA) 2031-03-03 RX search
Medimmune SYNAGIS palivizumab VIAL 103770 001 1998-06-19   Try a Free Trial University of Maryland, Baltimore (Baltimore, MA) 2031-03-03 RX search
Medimmune SYNAGIS palivizumab VIAL 103770 002 1998-06-19   Try a Free Trial University of Maryland, Baltimore (Baltimore, MA) 2031-03-03 RX search
Centocor Inc REMICADE infliximab VIAL 103772 001 1998-08-24   Try a Free Trial University of Maryland, Baltimore (Baltimore, MA) 2031-03-03 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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