Patent: 8,748,577
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Summary for Patent: 8,748,577
| Title: | Conjugates of biologically active polypeptides having an increased in vivo half-life |
| Abstract: | Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating peptide motif, wherein the biologically active protein conjugate exhibits a modified plasma half-life compared to the intrinsic half-life of the unconjugated biologically active polypeptide or protein. Also disclosed are methods of making and using the conjugated proteins, as well as methods for determining whether a given conjugate exhibits a modified half life relative to the intrinsic half life of the unconjugated polypeptide. |
| Inventor(s): | Besman; Marc (Seattle, WA), Chipman; Stewart (Bainbridge Island, WA), Leung; David (Mercer Island, WA), Singer; Jack (Seattle, WA) |
| Assignee: | Cell Therapeutics, Inc. (Seattle, WA) |
| Application Number: | 13/363,278 |
| Patent Claims: | see list of patent claims |
Details for Patent 8,748,577
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Genzyme Corporation | CEREZYME | imiglucerase | For Injection | 020367 | 05/23/1994 | ⤷ Try a Trial | 2025-01-25 |
| Genzyme Corporation | CEREZYME | imiglucerase | For Injection | 020367 | 09/22/1999 | ⤷ Try a Trial | 2025-01-25 |
| Recordati Rare Diseases, Inc. | ELSPAR | asparaginase | For Injection | 101063 | 01/10/1978 | ⤷ Try a Trial | 2025-01-25 |
| Smith & Nephew, Inc. | SANTYL | collagenase | Ointment | 101995 | 06/04/1965 | ⤷ Try a Trial | 2025-01-25 |
| Genentech, Inc. | ACTIVASE | alteplase | For Injection | 103172 | 11/13/1987 | ⤷ Try a Trial | 2025-01-25 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
