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Last Updated: January 28, 2020

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Patent: 8,748,577

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Summary for Patent: 8,748,577
Title:Conjugates of biologically active polypeptides having an increased in vivo half-life
Abstract: Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating peptide motif, wherein the biologically active protein conjugate exhibits a modified plasma half-life compared to the intrinsic half-life of the unconjugated biologically active polypeptide or protein. Also disclosed are methods of making and using the conjugated proteins, as well as methods for determining whether a given conjugate exhibits a modified half life relative to the intrinsic half life of the unconjugated polypeptide.
Inventor(s): Besman; Marc (Seattle, WA), Chipman; Stewart (Bainbridge Island, WA), Leung; David (Mercer Island, WA), Singer; Jack (Seattle, WA)
Assignee: Cell Therapeutics, Inc. (Seattle, WA)
Application Number:13/363,278
Patent Claims:see list of patent claims

Details for Patent 8,748,577

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genzyme FABRAZYME agalsidase beta VIAL; INTRAVENOUS 103979 002 2003-04-24   Start Trial Cell Therapeutics, Inc. (Seattle, WA) 2025-01-25 RX Orphan search
Genzyme FABRAZYME agalsidase beta VIAL; INTRAVENOUS 103979 001 2003-04-24   Start Trial Cell Therapeutics, Inc. (Seattle, WA) 2025-01-25 RX Orphan search
Genentech CATHFLO ACTIVASE alteplase VIAL 103172 003 1987-11-13   Start Trial Cell Therapeutics, Inc. (Seattle, WA) 2025-01-25 RX search
Genentech ACTIVASE alteplase VIAL; SINGLE-USE 103172 002 1987-11-13   Start Trial Cell Therapeutics, Inc. (Seattle, WA) 2025-01-25 RX search
Genentech ACTIVASE alteplase VIAL; SINGLE-USE 103172 001 1987-11-13   Start Trial Cell Therapeutics, Inc. (Seattle, WA) 2025-01-25 RX search
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Cell Therapeutics, Inc. (Seattle, WA) 2025-01-25 RX search
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Cell Therapeutics, Inc. (Seattle, WA) 2025-01-25 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 8,748,577

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