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Last Updated: April 26, 2024

Patent: 8,092,998

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Summary for Patent: 8,092,998

Title:	Biomarkers predictive of the responsiveness to TNF.alpha. inhibitors in autoimmune disorders
Abstract:	The invention provides methods for predicting responsiveness to TNF.alpha. inhibitors in a subject suffering from an autoimmune disorder, such as rheumatoid arthritis. The methods involve assaying for expression of one or more biomarkers in the subject that are predictive of responsiveness to TNF.alpha. inhibitors. A preferred biomarker of the invention is CD11c. The methods can further comprise selecting a treatment regimen with a TNF.alpha. inhibitor in an autoimmune disorder subject based upon expression of the biomarker(s) in the subject. The methods can further comprise administering a TNF.alpha. inhibitor to the subject according to the selected treatment regimen. Kits that include means for measuring expression of one or more biomarkers that are predictive of responsiveness to TNF.alpha. inhibitors for an autoimmune disorder are also provided. Methods of preparing and using databases, and computer program products therefore, for selecting an autoimmune disorder subject for treatment with a TNF.alpha. inhibitor are also provided.
Inventor(s):	Stuhlmuller; Bruno (Berlin, DE), Burmester; Gerd-Reudiger (Berlin, DE)
Assignee:	Abbott Laboratories (Abbott Park, IL)
Application Number:	12/130,373
Patent Claims:	see list of patent claims

Details for Patent 8,092,998

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Janssen Biotech, Inc.	REMICADE	infliximab	For Injection	103772	08/24/1998	⤷ Try a Trial	2027-05-31
Immunex Corporation	ENBREL	etanercept	For Injection	103795	11/02/1998	⤷ Try a Trial	2027-05-31
Immunex Corporation	ENBREL	etanercept	For Injection	103795	05/27/1999	⤷ Try a Trial	2027-05-31
Immunex Corporation	ENBREL	etanercept	Injection	103795	09/27/2004	⤷ Try a Trial	2027-05-31
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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