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Generated: September 19, 2019

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Patent: 8,007,790

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Summary for Patent: 8,007,790
Title:Methods for treating polycystic kidney disease (PKD) or other cyst forming diseases
Abstract: The present invention is directed to methods of treating or ameliorating an effect of a polycystic disease. More particularly, the methods include administering to a patient in need thereof an amount of a modulator of a tumor necrosis factor (TNF) pathway, which is sufficient to treat or ameliorate an effect of a polycystic disease. Methods of treating or ameliorating an effect of a polycystic kidney disease (PKD) are also provided. Methods are also provided for identifying a candidate compound that may be effective to treat or ameliorate an effect of a polycystic disease or to increase polycystin-2 (PC2) function or decrease Rab11-Family of Interacting Protein2 (FIP2) function. Further provided are methods for identifying a patient having, or who is at risk for developing, a polycystic disease or who would benefit from treatment with a TNF-alpha inhibitor.
Inventor(s): Li; Rong (Kansas City, MO), Li; Xiaogang (Prairie Village, KS)
Assignee: Stowers Institute for Medical Research (Kansas City, MO)
Application Number:11/906,600
Patent Claims:see list of patent claims

Details for Patent 8,007,790

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Centocor Inc REMICADE infliximab VIAL 103772 001 1998-08-24 ➤ Sign Up Stowers Institute for Medical Research (Kansas City, MO) 2027-04-03 RX Orphan search
Immunex ENBREL etanercept VIAL; SUBCUTANEOUS 103795 001 1998-11-02 ➤ Sign Up Stowers Institute for Medical Research (Kansas City, MO) 2027-04-03 RX Orphan search
Immunex ENBREL etanercept SYRINGE 103795 002 1998-11-02 ➤ Sign Up Stowers Institute for Medical Research (Kansas City, MO) 2027-04-03 RX Orphan search
Abbvie Inc HUMIRA adalimumab SYRINGE 125057 001 2002-12-31 ➤ Sign Up Stowers Institute for Medical Research (Kansas City, MO) 2027-04-03 RX search
Abbvie Inc HUMIRA adalimumab VIAL 125057 002 2002-12-31 ➤ Sign Up Stowers Institute for Medical Research (Kansas City, MO) 2027-04-03 RX search
Ucb Inc CIMZIA certolizumab pegol INJECTABLE; INJECTION 125160 001 2008-04-22 ➤ Sign Up Stowers Institute for Medical Research (Kansas City, MO) 2027-04-03 RX search
Centocor Ortho Biotech Inc SIMPONI golimumab INJECTABLE; INJECTION 125289 001 2009-04-24 ➤ Sign Up Stowers Institute for Medical Research (Kansas City, MO) 2027-04-03 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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International Patent Family for US Patent 8,007,790

Country Patent Number Publication Date
Canada 2648407 Oct 18, 2007
European Patent Office 2035038 Apr 06, 2011
European Patent Office 2035038 Mar 18, 2009
Japan 2009532495 Sep 10, 2009
United States of America 2008269123 Oct 30, 2008
World Intellectual Property Organization (WIPO) 2007118084 Oct 16, 2008
World Intellectual Property Organization (WIPO) 2007118084 Oct 18, 2007
>Country >Patent Number >Publication Date

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