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Last Updated: March 30, 2023

Patent: 5,654,403

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Summary for Patent: 5,654,403
Title: Immunoglobulins stabilized with a chelator of copper ions
Abstract:A stabilized immunoglobulin composition comprises at least one immunoglobulin together with a stabilizing amount of a chelator of copper ions such as EDTA or citrate. Preferably the immunoglobulin is an antibody, for example, a recombinant CDR-grafted antibody. A process for enhancing the stability of an immunoglobulin comprises subjecting the immunoglobulin to a purification procedure capable of removing copper ions therefrom. Preferably, the immunoglobulin is rendered substantially free from detectable copper ions as determined, for example, by atomic absorption spectroscopy.
Inventor(s): Smith; Marjorie (Beckenham, GB3), Riveros-Rojas; Valentina (Beckenham, GB3)
Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC)
Application Number:08/232,127
Patent Claims:see list of patent claims

Details for Patent 5,654,403

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genzyme Corporation CAMPATH alemtuzumab Injection 103948 05/07/2001 ⤷  Sign Up 2014-08-05
Genzyme Corporation LEMTRADA alemtuzumab Injection 103948 11/14/2014 ⤷  Sign Up 2014-08-05
Genzyme Corporation CAMPATH alemtuzumab Injection 103948 10/12/2004 ⤷  Sign Up 2014-08-05
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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