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Last Updated: July 29, 2021

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Patent: 5,654,403

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Summary for Patent: 5,654,403
Title: Immunoglobulins stabilized with a chelator of copper ions
Abstract:A stabilized immunoglobulin composition comprises at least one immunoglobulin together with a stabilizing amount of a chelator of copper ions such as EDTA or citrate. Preferably the immunoglobulin is an antibody, for example, a recombinant CDR-grafted antibody. A process for enhancing the stability of an immunoglobulin comprises subjecting the immunoglobulin to a purification procedure capable of removing copper ions therefrom. Preferably, the immunoglobulin is rendered substantially free from detectable copper ions as determined, for example, by atomic absorption spectroscopy.
Inventor(s): Smith; Marjorie (Beckenham, GB3), Riveros-Rojas; Valentina (Beckenham, GB3)
Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC)
Application Number:08/232,127
Patent Claims:see list of patent claims

Details for Patent 5,654,403

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genzyme LEMTRADA alemtuzumab INJECTABLE;INJECTION 103948 003 2001-05-07 ⤷  Try it Free Burroughs Wellcome Co. (Research Triangle Park, NC) 2014-08-05 RX Orphan company
Genzyme CAMPATH alemtuzumab VIAL; INTRAVENOUS 103948 002 2001-05-07 ⤷  Try it Free Burroughs Wellcome Co. (Research Triangle Park, NC) 2014-08-05 RX Orphan company
Genzyme CAMPATH alemtuzumab VIAL; INTRAVENOUS 103948 001 2001-05-07 ⤷  Try it Free Burroughs Wellcome Co. (Research Triangle Park, NC) 2014-08-05 RX Orphan company
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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