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Last Updated: March 29, 2024

Patent: 5,792,838


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Summary for Patent: 5,792,838
Title: Method for stabilizing immunoglobulin compositions
Abstract:The invention relates to a stabilised immunoglobulin composition comprising at least one immunoglobulin together with a stabilising amount of a chelator of copper ions such as EDTA or citrate. Preferably the immunoglobulin is an antibody, for example a recombinant CDR-grafted antibody against the CDw52 antigen, most preferably CAMPATH-1H. The invention also relates to a process for enhancing the stability of an immunoglobulin which comprises subjecting the immunoglobulin to a purification procedure capable of removing copper ions therefrom. Preferably the immunoglobulin is rendered substantially free from detectable copper ions, for example on atomic absorption spectroscopy.
Inventor(s): Smith; Marjorie (Beckenham, GB3), Riveros-Rojas; Valentina (Beckenham, GB3)
Assignee: Glaxo Wellcome Inc. (Research Triangle Park, NC)
Application Number:08/465,319
Patent Claims:see list of patent claims

Details for Patent 5,792,838

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genzyme Corporation CAMPATH alemtuzumab Injection 103948 05/07/2001 ⤷  Try a Trial 2015-08-11
Genzyme Corporation LEMTRADA alemtuzumab Injection 103948 11/14/2014 ⤷  Try a Trial 2015-08-11
Genzyme Corporation CAMPATH alemtuzumab Injection 103948 10/12/2004 ⤷  Try a Trial 2015-08-11
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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