Last Updated: June 25, 2026

Patent: 5,474,978

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Summary for Patent: 5,474,978

Title:	Insulin analog formulations
Abstract:	The present invention discloses a human insulin analog hexamer complex and formulations. More specifically, the present invention relates to various parenteral formulations, which comprise: human insulin analogs in a hexamer conformation, zinc ions, and at least three molecules of a phenolic derivative selected from the group consisting of m-cresol, phenol, or a mixture of m-cresol and phenol. The formulation provides a rapid onset of action.
Inventor(s):	Diane L. Bakaysa, David N. Brems, Bruce H. Frank, Henry A. Havel, Allen H. Pekar
Assignee:	Eli Lilly and Co
Application Number:	US08/260,634
Patent Claims:	see list of patent claims

Details for Patent 5,474,978

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Eli Lilly And Company	HUMALOG	insulin lispro	Injection	205747	May 26, 2015	5,474,978	2014-06-16
Sanofi-aventis U.s. Llc	ADMELOG	insulin lispro	Injection	209196	December 11, 2017	5,474,978	2014-06-16
Sanofi-aventis U.s. Llc	ADMELOG	insulin lispro	Injection	209196	October 19, 2018	5,474,978	2014-06-16
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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