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Last Updated: July 6, 2020

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Patent: 10,195,175

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Summary for Patent: 10,195,175
Title:Synergistic effect of anti-Trop-2 antibody-drug conjugate in combination therapy for triple-negative breast cancer when used with microtubule inhibitors or PARP inhibitors
Abstract: The present invention relates to combination therapy with ADCs against a tumor-associated antigen, such as Trop-2, and drugs, such as microtubule inhibitors and/or PARP inhibitors. Where ADCs are used, they preferably incorporate SN-38 or another drug that induces DNA strand breaks. Preferably, the combination of ADC and PARPi or microtubule inhibitor exhibits synergistic effects against the cancer. The combination therapy can reduce solid tumors in size, reduce or eliminate metastases and is effective to treat cancers resistant to standard therapies, such as radiation therapy, chemotherapy or immunotherapy.
Inventor(s): Goldenberg; David M. (Mendham, NJ), Cardillo; Thomas M. (Cedar Knolls, NJ)
Assignee: Immunomedics, Inc. (Morris Plains, NJ)
Application Number:15/481,090
Patent Claims:see list of patent claims

Details for Patent 10,195,175

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Immunomedics, Inc. TRODELVY sacituzumab govitecan POWDER, FOR SOLUTION 761115 1 2020-04-22   Start Trial Immunomedics, Inc. (Morris Plains, NJ) 2035-06-25 search
Immunomedics Inc TRODELVY sacituzumab govitecan-hziy INJECTABLE;INJECTION 761115 001 2020-04-22   Start Trial Immunomedics, Inc. (Morris Plains, NJ) 2035-06-25 RX search
Emd Serono Inc BAVENCIO avelumab INJECTABLE;INTRAVENOUS 761078 001 2017-05-09   Start Trial Immunomedics, Inc. (Morris Plains, NJ) 2035-06-25 RX search
Astrazeneca Uk Ltd IMFINZI durvalumab INJECTABLE;INJECTION 761069 001 2017-05-01   Start Trial Immunomedics, Inc. (Morris Plains, NJ) 2035-06-25 RX search
Emd Serono Inc BAVENCIO avelumab INJECTABLE;INJECTION 761049 001 2017-04-25   Start Trial Immunomedics, Inc. (Morris Plains, NJ) 2035-06-25 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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