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Last Updated: April 26, 2024

Patent: 10,184,121

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Summary for Patent: 10,184,121

Title:	Methods for removing viral contaminants from pancreatic extracts
Abstract:	Methods for screening pancrelipase for RNA virus contamination comprise removing free viral RNA from the pancrelipase, denaturing any viruses in the pancrelipase to release encapsidated RNA into the pancrelipase milieu, and detecting this released RNA. Removal of free viral RNA may comprise treating pancrelipase with RNase and DNase or precipitating the protein fraction of pancrelipase with a salt that precipitates the protein fraction while leaving nucleic acids such as RNA in solution. Pancrelipase substantially devoid of free nucleic acid is also provided.
Inventor(s):	Ortenzi; Giovanni (Monza, IT), Ghidorsi; Luigi (Milan, IT)
Assignee:	ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED (Dublin, IE)
Application Number:	14/744,447
Patent Claims:	see list of patent claims

Details for Patent 10,184,121

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Organon Usa Inc., A Subsidiary Of Merck & Co., Inc.	COTAZYM	pancrelipase	Capsule, Delayed Release	020580	12/09/1996	⤷ Try a Trial	2034-06-19
Abbvie Inc.	CREON	pancrelipase	Capsule, Delayed Release	020725	04/30/2009	⤷ Try a Trial	2034-06-19
Abbvie Inc.	CREON	pancrelipase	Capsule, Delayed Release	020725	06/10/2011	⤷ Try a Trial	2034-06-19
Abbvie Inc.	CREON	pancrelipase	Capsule, Delayed Release	020725	03/14/2013	⤷ Try a Trial	2034-06-19
Digestive Care, Inc.	PERTZYE	pancrelipase	Capsule, Delayed Release	022175	05/17/2012	⤷ Try a Trial	2034-06-19
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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