Last Updated: June 25, 2026

Patent: 10,155,799

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Summary for Patent: 10,155,799

Title:	Chromatography process for purification of insulin and insulin analogs
Abstract:	A process is described for purifying insulin and insulin analogs that comprises use of two or more orthogonal chromatographic purification steps in tandem following enzymatic digestion of the propeptide-insulin precursor to remove specific product impurities, improve process consistency, and increase process redundancy in the purification of the insulin or insulin analog, e.g., insulin lispro.
Inventor(s):	Watson; Douglas S. (Harrisonburg, VA), Ortigosa; Allison D. (Harrisonburg, VA), Rauscher; Michael A. (Garwood, NJ), Story; Kathryn M. (Harrisonburg, VA)
Assignee:	Merck Sharp & Dohme Corp. (Rahway, NJ)
Application Number:	15/327,096
Patent Claims:	see list of patent claims

Details for Patent 10,155,799

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Eli Lilly And Company	HUMALOG	insulin lispro	Injection	020563	June 14, 1996	⤷ Start Trial	2035-07-16
Eli Lilly And Company	HUMALOG	insulin lispro	Injection	020563	August 06, 1998	⤷ Start Trial	2035-07-16
Eli Lilly And Company	HUMALOG	insulin lispro	Injection	020563	September 06, 2007	⤷ Start Trial	2035-07-16
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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