Patent: 10,144,779
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Summary for Patent: 10,144,779
Title: | Anti-CTLA-4 antibodies and methods of use thereof |
Abstract: | The instant disclosure provides antibodies that specifically bind to human CTLA-4 and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies. |
Inventor(s): | van Dijk; Marc (Bosch en Duin, NL), Mundt; Cornelia Anne (Lorrach, DE), Ritter; Gerd (New York, NY), Schaer; David (Mamaroneck, NY), Wolchok; Jedd David (New York, NY), Merghoub; Taha (Jersey City, NJ), Savitsky; David Adam (Boxford, MA), Wilson; Nicholas Stuart (San Carlos, CA) |
Assignee: | AGENUS INC. (Lexington, MA) LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (Zurich, CH) MEMORIAL SLOAN KETTERING CANCER CENTER (New York, NY) |
Application Number: | 15/166,305 |
Patent Claims: | see list of patent claims |
Details for Patent 10,144,779
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Genentech, Inc. | AVASTIN | bevacizumab | Injection | 125085 | 02/26/2004 | ⤷ Try a Trial | 2035-05-29 |
Merck Sharp & Dohme Corp. | KEYTRUDA | pembrolizumab | For Injection | 125514 | 09/04/2014 | ⤷ Try a Trial | 2035-05-29 |
Merck Sharp & Dohme Corp. | KEYTRUDA | pembrolizumab | Injection | 125514 | 01/15/2015 | ⤷ Try a Trial | 2035-05-29 |
Bristol-myers Squibb Company | OPDIVO | nivolumab | Injection | 125554 | 12/22/2014 | ⤷ Try a Trial | 2035-05-29 |
Bristol-myers Squibb Company | OPDIVO | nivolumab | Injection | 125554 | 10/04/2017 | ⤷ Try a Trial | 2035-05-29 |
Bristol-myers Squibb Company | OPDIVO | nivolumab | Injection | 125554 | 08/27/2021 | ⤷ Try a Trial | 2035-05-29 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |