Last Updated: August 9, 2026

Patent: 10,130,598

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Summary for Patent: 10,130,598

Title:	Methods and compositions for administration of 3-halopyruvate and related compounds for the treatment of cancer
Abstract:	The present disclosure relates to the discovery that compounds of the invention, particularly 3-bromopyruvate and related compounds, can be safely administered at concentrations effective for the treatment of cancer when formulated with an acidity of greater than or equal to pH of 2 and less than or equal to a pH of 6. Disclosed herein are novel and improved methods and compositions for the treatment of cancer using 3-halopyruvate and related compounds.
Inventor(s):	Geschwind; Jean-Francois (Potoman, MD), Vali; Mustafa (Baltimore, MD)
Assignee:	The Johns Hopkins University (Baltimore, MD)
Application Number:	15/284,014
Patent Claims:	see list of patent claims

Details for Patent 10,130,598

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	January 10, 1978	10,130,598	2036-10-03
Merck Sharp & Dohme Llc	INTRON A	interferon alfa-2b	For Injection	103132	June 04, 1986	10,130,598	2036-10-03
Merck Sharp & Dohme Llc	INTRON A	interferon alfa-2b	For Injection	103132		10,130,598	2036-10-03
Merck Sharp & Dohme Llc	INTRON A	interferon alfa-2b	Injection	103132		10,130,598	2036-10-03
Hoffmann-la Roche Inc.	ROFERON-A	interferon alfa-2a	For Injection	103145	June 04, 1986	10,130,598	2036-10-03
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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