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Last Updated: February 1, 2023

Patent: 10,066,019


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Summary for Patent: 10,066,019
Title:Optimised heavy chain and light chain signal peptides for the production of recombinant antibody therapeutics
Abstract: Antibodies of interest comprising a heavy chain signal peptide and/or a light chain signal peptide or combination thereof and compositions are described. The method of determining the signal peptide including creating data set of antibodies signal peptides, clustering, selecting and creating recombinant antibodies for enhanced expression and secretion are described.
Inventor(s): Song; Zhiwei (Singapore, SG)
Assignee: Agency for Science, Technology and Research (Singapore, SG)
Application Number:14/435,094
Patent Claims:see list of patent claims

Details for Patent 10,066,019

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. RITUXAN rituximab Injection 103705 11/26/1997 See Plans and Pricing 2032-10-12
Idec Pharmaceuticals Corp. RITUXAN rituximab Injection 103737 02/19/2002 See Plans and Pricing 2032-10-12
Janssen Biotech, Inc. REMICADE infliximab For Injection 103772 08/24/1998 See Plans and Pricing 2032-10-12
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 09/25/1998 See Plans and Pricing 2032-10-12
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 02/10/2017 See Plans and Pricing 2032-10-12
Abbvie Inc. HUMIRA adalimumab Injection 125057 12/31/2002 See Plans and Pricing 2032-10-12
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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