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Last Updated: September 20, 2020

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Patent: 10,066,019

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Summary for Patent: 10,066,019
Title:Optimised heavy chain and light chain signal peptides for the production of recombinant antibody therapeutics
Abstract: Antibodies of interest comprising a heavy chain signal peptide and/or a light chain signal peptide or combination thereof and compositions are described. The method of determining the signal peptide including creating data set of antibodies signal peptides, clustering, selecting and creating recombinant antibodies for enhanced expression and secretion are described.
Inventor(s): Song; Zhiwei (Singapore, SG)
Assignee: Agency for Science, Technology and Research (Singapore, SG)
Application Number:14/435,094
Patent Claims:see list of patent claims

Details for Patent 10,066,019

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech RITUXAN rituximab SOLUTION;INTRAVENOUS 103705 001 1997-11-26   Start Trial Agency for Science, Technology and Research (Singapore, SG) 2032-10-12 RX search
Genentech RITUXAN rituximab SOLUTION;INTRAVENOUS 103705 002 1997-11-26   Start Trial Agency for Science, Technology and Research (Singapore, SG) 2032-10-12 RX search
Centocor Inc REMICADE infliximab VIAL 103772 001 1998-08-24   Start Trial Agency for Science, Technology and Research (Singapore, SG) 2032-10-12 RX Orphan search
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial Agency for Science, Technology and Research (Singapore, SG) 2032-10-12 RX Orphan search
Abbvie Inc HUMIRA adalimumab SYRINGE 125057 001 2002-12-31   Start Trial Agency for Science, Technology and Research (Singapore, SG) 2032-10-12 RX search
Abbvie Inc HUMIRA adalimumab VIAL 125057 002 2002-12-31   Start Trial Agency for Science, Technology and Research (Singapore, SG) 2032-10-12 RX search
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 001 2004-02-26   Start Trial Agency for Science, Technology and Research (Singapore, SG) 2032-10-12 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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