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Last Updated: September 27, 2020

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Patent: 10,022,427

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Summary for Patent: 10,022,427
Title:Interferon lambda-antibody complexes
Abstract: The present invention concerns methods and compositions for forming complexes of interferon-.lamda. with an antibody or antigen-binding antibody fragment. In preferred embodiments, the interferon-.lamda. and the antibody or fragment are fusion proteins, each comprising a dimerization and docking domain (DDD) moiety from human protein kinase A or an anchor domain (AD) moiety from an A-kinase anchoring protein (AKAP). In more preferred embodiments, the interferon-antibody complex is more efficacious for treatment of cancer, asthma, Alzheimer\'s disease, multiple sclerosis or viral infection than interferon-.lamda. alone, antibody alone, or the combination of unconjugated interferon-.lamda. and antibody.
Inventor(s): Chang; Chien-Hsing (Downingtown, PA), Goldenberg; David M. (Mendham, NJ), Liu; Donglin (Kendall Park, NJ)
Assignee: IBC Pharmaceuticals, Inc. (Morris Plains, NJ)
Application Number:14/997,843
Patent Claims:see list of patent claims

Details for Patent 10,022,427

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2028-04-10 RX search
Genzyme CAMPATH alemtuzumab VIAL; INTRAVENOUS 103948 001 2001-05-07   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2028-04-10 RX Orphan search
Genzyme CAMPATH alemtuzumab VIAL; INTRAVENOUS 103948 002 2001-05-07   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2028-04-10 RX Orphan search
Genzyme LEMTRADA alemtuzumab INJECTABLE;INJECTION 103948 003 2001-05-07   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2028-04-10 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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