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Last Updated: January 23, 2020

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Claims for Patent: 9,822,129

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Summary for Patent: 9,822,129
Title:Amido spirocyclic amide and sulfonamide derivatives
Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
Inventor(s): Bair; Kenneth W (Watertown, MA), Baumeister; Timm R (Watertown, MA), Dragovich; Peter (South San Francisco, CA), Liu; Xiongcai (Beijing, CN), Patel; Snahel (South San Francisco, CA), Yuen; Po-Wai (Beijing, CN), Zak; Mark (South San Francisco, CA), Zhao; Guiling (South San Francisco, CA), Zhang; Yamin (Beijing, CN), Zheng; Xiaozhang (Watertown, MA)
Assignee: Genentech, Inc. (South San Francisco, CA) Forma TM, LLC (Watertown, MA)
Application Number:14/382,210
Patent Claims:1. A compound of Formula I: ##STR00457## wherein: R is (a) an 8-, 9-, or 10-membered bicyclic heteroaryl comprising one heteroatom selected from N, S, and O, and one, two, or three additional N atoms, wherein said bicyclic heteroaryl is unsubstituted or is substituted with one or more substituents selected from the group consisting of deuterium, amino, alkylamino, dialkylamino, alkyl, halo, cyano, haloalkyl, hydroxy, hydroxyalkyl, and alkoxy, and wherein one or more N atoms of said bicyclic heteroaryl is optionally an N-oxide; or (b) a five- or six-membered nitrogen-linked heterocycloalkyl ring fused to a phenyl or monocyclic five- or six-membered heteroaryl, wherein said phenyl or heteroaryl is unsubstituted or is substituted with one or more substituents selected from the group consisting of deuterium, amino, alkylamino, dialkylamino, alkyl, halo, cyano, haloalkyl, hydroxy, hydroxyalkyl, and alkoxy; and R.sup.1 is H, --(C.sub.1-4alkylene).sub.0-1C(O)R.sup.a, --(C.sub.1-4alkylene).sub.0-1CO.sub.2R.sup.a, --(C.sub.1-4alkylene).sub.0-1S(O)R.sup.a, --(C.sub.1-4alkylene).sub.0-1SO.sub.2R.sup.a, --C(O)NH(R.sup.a), --C(O)N(R.sup.a).sub.2, or --C(O)C(O)NH(R.sup.a); wherein each R.sup.a is independently (1) alkyl, unsubstituted or substituted with one or more R.sup.m substituents, wherein each R.sup.m is independently selected from the group consisting of hydroxy, --NR.sup.bR.sup.c, alkoxy, cyano, halo, --C(O)alkyl, --CO.sub.2alkyl, --CONR.sup.bR.sup.c, --S(O)alkyl, --SO.sub.2alkyl, --SO.sub.2NR.sup.bR.sup.c, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, phenoxy, and --O-alkyl-OH; wherein R.sup.b is H or alkyl; R.sup.c is H, alkyl, alkoxyalkyl, haloalkyl, --C(O)alkyl, --CO.sub.2alkyl, --SO.sub.2alkyl, --C(O)NH.sub.2, or C(O)H; and each aryl, heteroaryl, cycloalkyl, and heterocycloalkyl group within R.sup.m is unsubstituted or substituted with one or more substituents independently selected from the group consisting of alkyl, haloalkyl, hydroxy, --NR.sup.bR.sup.c, alkoxy, haloalkoxy, cyano, halo, oxo, --C(O)alkyl, --CO.sub.2alkyl, --C(O)-heterocycloalkyl, --CONR.sup.bR.sup.c, --S(O)alkyl, --SO.sub.2alkyl, --SO.sub.2-haloalkyl, --SO.sub.2NR.sup.bR.sup.c, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl; wherein each alkyl or alkoxy is unsubstituted or substituted with --NR.sup.bR.sup.c, heterocycloalkyl, heteroaryl, or --C(O)alkyl; and each aryl, heteroaryl, cycloalkyl, and heterocycloalkyl is unsubstituted or substituted with alkyl, halo, or --C(O)alkyl; (2) phenyl, cycloalkyl, heteroaryl, or heterocycloalkyl, each unsubstituted or substituted with one or more substituents selected from the group consisting of alkyl, haloalkyl, hydroxy, --NR.sup.bR.sup.c, alkoxy, haloalkoxy, cyano, halo, oxo, --C(O)alkyl, --CO.sub.2alkyl, --C(O)-heterocycloalkyl, --CONR.sup.bR.sup.c, --S(O)alkyl, --SO.sub.2alkyl, --SO.sub.2-haloalkyl, --SO.sub.2NR.sup.bR.sup.c, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl; wherein each alkyl or alkoxy is unsubstituted or substituted with --NR.sup.bR.sup.c, heterocycloalkyl, heteroaryl, or --C(O)alkyl; and each aryl, heteroaryl, cycloalkyl, and heterocycloalkyl is unsubstituted or substituted with alkyl, halo, or --C(O)alkyl; or (3) --NR.sup.xR.sup.y, where R.sup.x is H or alkyl; and R.sup.y is H, alkyl, alkoxyalkyl, haloalkyl, --C(O)alkyl, --CO.sub.2alkyl, or --SO.sub.2alkyl; R.sup.2 and R.sup.3 are each independently H or deuterium; and n is 1 or 2; or a stereoisomer thereof, or a pharmaceutically acceptable salt of such a compound or stereoisomer.

2. The compound of claim 1, wherein R is an 8- or 9-membered heteroaryl, unsubstituted or substituted as described for claim 1.

3. The compound of claim 1, wherein R is: ##STR00458## each unsubstituted or substituted as described for claim 1.

4. The compound of claim 1, wherein, R is a five- or six-membered nitrogen-linked heterocycloalkyl ring fused to an unsubstituted or substituted phenyl or monocyclic heteroaryl, as defined in claim 1.

5. The compound of claim 1, wherein R is ##STR00459##

6. The compound of claim 1, wherein R.sup.1 is H, --C(O)R.sup.a, --CO.sub.2R.sup.a, --S(O)R.sup.a, or --SO.sub.2R.sup.a.

7. The compound of claim 1, wherein R.sup.a is methyl, ethyl, propyl, isopropyl, tert-butyl, isobutyl, isopentyl, phenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, pyrrolyl, furanyl, thiophenyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, triazoyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, isoindolinyl, azetidinyl, oxetanyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, tetrahydrofuranyl, tetrahydropyranyl, or tetrahydrothiophenyl, each unsubstituted or substituted.

8. The compound of claim 1, wherein R.sup.a is phenyl, cycloalkyl, heteroaryl, or heterocycloalkyl, each unsubstituted or substituted with one or more substituents selected from the group consisting of fluoro, oxo, methyl, --CONH.sub.2, acetyl, --SO.sub.2methyl, --C(O)-isopropyl, pyridazinyl, triazolyl, dimethylaminomethyl, cyano, methyl-triazolyl-methoxy, trifluoromethoxy, pyrrolidinylmethyl, acetylamino, tetrazolylmethyl, methyl-tetrazolyl-methyl, methyl-imidazolyl-methyl, --NHSO.sub.2methyl, 1,1-dioxothiomorpholinyl, 4-methyl-piperazinylmethyl, --NHCONH.sub.2, --SO.sub.2CF.sub.3, morpholinylmethyl, imidazolyl, --SO.sub.2NH.sub.2, methylpiperidinyl, methyl-piperazinyl, --C(O)(4-methyl-piperazinyl), morpholinyl, trifluoromethyl, cyclopropyl, ethyl, isoxazolyl, tetrazolyl, isopropyl, phenyl, fluoro-phenyl, tert-butyl, benzyl, N-methylpyrrolidinyl, N-acetyl-pyrrolidinyl, isobutyl, propyl, methylpyrazolyl, trifluoroethyl, pyrimidinyl, oxo, acetyl, cyano, --CO.sub.2-tert-butyl, and amino.

9. The compound of claim 1, wherein R.sup.a is alkyl, unsubstituted or substituted with one or more substituents selected from the group consisting of fluoro, tert-butoxy, --C(O)NMe.sub.2, --NHCHO, methoxy, phenoxy, cyano, acetyl, hydroxy, --OCH.sub.2C(CH.sub.3).dbd.OH, --NH(acetyl), and --N(Me)(acetyl).

10. The compound of claim 1, wherein R.sup.1 is --SO.sub.2R.sup.a, where R.sup.a is methyl, ethyl, phenyl, benzyl, or 2,2-dimethylpropyl.

11. The compound of claim 1, wherein R.sup.1 is --C(O)NHR.sup.a, wherein R.sup.a is methyl, ethyl, propyl, isopropyl, tertobutyl, cyclohexyl, --CH.sub.2-cyclohexyl, oxetanyl, or methyloxetanyl, or R.sup.a is a phenyl or benzyl group, each optionally substituted with one or more substituents selected from the group consisting of cyano, methyl, fluoro, methoxy, and chloro.

12. The compound of claim 1, wherein both R.sup.2 and R.sup.3 are H.

13. The compound of claim 1, which is a compound of Formula I-a: ##STR00460## wherein R, R.sup.1, R.sup.2, and R.sup.3 are as defined for Formula I; or a stereoisomer thereof, or a pharmaceutically acceptable salt of such a compound or stereoisomer.

14. A compound selected from the group consisting of: TABLE-US-00008 ##STR00461## tert-butyl 2-[(1,3- dihydropyrrolo[3,4- c]pyridine-2- carbonylamino)methyl]-8- azaspiro[2.5]octane-8- carboxylate; ##STR00462## tert-butyl 2-[(thieno[2,3- c]pyridine-2- carbonylamino)methyl]-8- azaspiro[2.5]octane-8- carboxylate; ##STR00463## tert-butyl 2-[(imidazo[1,2- a]pyrimidine-6- carbonylamino)methyl]-8- azaspiro[2.5]octane-8- carboxylate; ##STR00464## tert-butyl 2-[(furo[2,3- c]pyridine-2- carbonylamino)methyl]-8- azaspiro[2.5]octane-8- carboxylate; ##STR00465## tert-butyl 2-[(imidazo[1,2- a]pyridine-6- carbonylamino)methyl]-8- azaspiro[2.5]octane-8- carboxylate; ##STR00466## N-[[8-(3,3- dimethylbutanoyl)-8- azaspiro[2.5]octan-2- yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00467## N-[[8-(2-phenylacetyl)-8- azaspiro[2.5]octan-2- yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide ##STR00468## tert-butyl 2-[(1H-pyrrolo[3,2- c]pyridine-2- carbonylamino)methyl]-8- azaspiro[2.5]octane-8- carboxylate; ##STR00469## N-[[8- (cyclohexanecarbonyl)-8- azaspiro[2.5]octan-2- yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00470## N-[[8-(tetrahydropyran-4- carbonyl)-8- azaspiro[2.5]octan-2- yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00471## N-[(8-benzoyl-8- azaspiro[2.5]octan-2- yl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00472## N-[[8-(2-methylpropanoyl)-8- azaspiro[2.5]octan-2- yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00473## N-[[8-(benzenesulfonyl)-8- azaspiro[2.5]octan-2- yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide ##STR00474## N-[(8-ethylsulfonyl-8- azaspiro[2.5]octan-2- yl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00475## tert-butyl 2-[(1H- pyrazolo[3,4-b]pyridine-5- carbonylamino)methyl]-8- azaspiro[2.5]octane-8- carboxylate; ##STR00476## N-[(8-acetyl-8- azaspiro[2.5]octan-2- yl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00477## N-[(8-methylsulfonyl-8- azaspiro[2.5]octan-2- yl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00478## N-(8-azaspiro[2.5]octan-2- ylmethyl)-1H-pyrrolo[3.2- c]pyridine-2-carboxamide; ##STR00479## N-(8-azaspiro[2.5]octan-2- ylmethyl)-1H-pyrazolo[3,4- b]pyridine-5-carboxamide; ##STR00480## N-[(8-propanoyl-8- azaspiro[2.5]octan-2- yl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00481## tert-butyl 2-((imidazo[1,2- a]pyridine-6- carboxamido)methyl)-7- azaspiro[3.5]nonane-7- carboxylate; ##STR00482## tert-butyl 2-[(imidazo[1,2- a]pyridine-6- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00483## tert-butyl 2-[(furo[2,3- c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00484## N-[[6-(3,3- dimethylbutanoyl)-6- azaspiro[2.5]octan-2- yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00485## tert-butyl 2-[(1,3- dihydropyrrolo[3,4- c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00486## N-[[6-(2-imidazol-1-ylacetyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00487## N-[[6-(4,4,4- trifluorobutanoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00488## N-[[6-[2-(3- methylsulfonylphenyl)acetyl]- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00489## N-[[6-(3,3- dimethylbutanoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00490## N-[[6-[2-(4-methylpiperazin- 1-yl)acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00491## N-[[6-[2-(3- cyanophenyl)acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00492## N-[[6-(2-cyclopropylacetyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00493## N-[[6-(2-pyrrolidin-1- ylacetyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00494## N-[[6-[2-(3-methylisoxazol-5- yl)acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00495## N-[[6-[2-(1-piperidyl)acetyl]- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00496## N-[[6-(2-tetrahydropyran-4- ylacetyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00497## N-[[6-(2-tetrahydrofuran-2- ylacetyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00498## N-[[6-(2-tert-butoxyacetyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00499## N-[[6-[2-(3-pyridyl)acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00500## N-[[6-[2-[1-(2,2,2- trifluoroethyl)-4- piperidyl]acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00501## tert-butyl 2-[(imidazo[1,2- a]pyridine-6- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00502## tert-butyl 2-[(imidazo[1,2- a]pyridine-6- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00503## tert-butyl 2-[(furo[2,3- c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00504## tert-butyl 2-[(furo[2,3- c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00505## N-[[6-(3,3- dimethylbutanoyl)-6- azaspiro[2.5]octan-2- yl]methyl]-1,3- dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00506## N-[[6-(3-methylbutanoyl)-6- azaspiro[2.5]octan-2- yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00507## N-[[6-(2-phenylacetyl)-6- azaspiro[2.5]octan-2- yl]methyl]-1,3- dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00508## tert-butyl 2-[(1,3- dihydropyrrolo[3,4- c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00509## tert-butyl 2-[(1,3- dihydropyrrolo[3,4- c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00510## N-[[6-(2-pyrazin-2-ylacetyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00511## N-[[6-(2-morpholinoacetyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00512## N-[[6-(2-tetrahydropyran-2- ylacetyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00513## N-[[6-(2-pyrrolidin-1- ylpropanoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00514## N-[[6-[2-(tert-butylamino)-2- oxo-acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00515## N-[[6-[4-(dimethylamino)-4- oxo-butanoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00516## N-[[6-(1-methyl-5-oxo- pyrrolidine-3-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00517## N-[[6-[2-(2-oxopyrrolidin-1- yl)acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00518## N-[[6-(2,2- difluorocyclopropanecarbonyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00519## N-[[6-(tetrahydrofuran-3- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00520## N-[[6-(tetrahydropyran-4- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00521## N-[[6-(tetrahydrofuran-2- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00522## N-[[6-(2-formamidoacetyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00523## N-[[6-[3-(3,5- dimethylpyrazol-1- yl)propanoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00524## N-[[6-(1- carbamoylpyrrolidine-2- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00525## N-[[6-(3- morpholinopropanoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00526## N-[[6-(1,1-dioxothiolane-3- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00527## N-[[6-[2-(3,5- dimethylpyrazol-1-yl)acetyl]- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00528## N-[[6-(1-acetylpyrrolidine-2- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00529## N-[[6-(2- methylsulfonylbenzoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00530## N-[[6-[3-(1,2,4-triazol-4- yl)benzoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00531## N-[[6-[4- [(dimethylamino)methyl] benzoyl]-6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00532## N-[[6-(4-acetamidobenzoyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00533## N-[[6-(1- methylsulfonylpiperidine-3- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00534## N-[[6-(1- methylsulfonylpiperidine-4- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00535## N-[[6-(2- morpholinopropanoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00536## N-[[6-(1- methylsulfonylpyrrolidine-2- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00537## N-[[6-[2-(3-oxoisoindolin-1- yl)acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00538## N-[[6-(1- carbamoylpiperidine-4- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00539## N-[[6-(1- carbamoylpiperidine-3- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00540## N-[[6-[2-(1,1-dioxothiolan-3- yl)acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00541## N-[[6-[2-(2,4-dioxopyrimidin- 1-yl)acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00542## N-[[6-(1-acetylpiperidine-4- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide;

##STR00543## N-[[6-[4-(tetrazol-1- ylmethyl)benzoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00544## N-[[6-[4- (methanesulfonamido)benzoyl]- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00545## N-[[6-[4-(1,1-dioxo-1,4- thiazinan-4-yl)benzoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00546## N-[[6-[4-[(4-methylpiperazin- 1-yl)methyl]benzoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00547## N-[[6-[2-[(4-methylpiperazin- 1-yl)methyl]benzoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00548## N-[[6-[3-[(4-methylpiperazin- 1-yl)methyl]benzoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00549## N-[[6-[3-(4-methylpiperazin- 1-yl)propanoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00550## N-[[6-(1-isopropyl-5-oxo- pyrrolidine-3-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00551## N-[[6-[2-(3-oxopiperazin-1- yl)acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00552## N-[[6-(3- methylsulfonylbenzoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00553## N-[[6-(4- methylsulfonylbenzoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00554## N-[[6-(4-ureidobenzoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00555## N-[[6-[2-(4-acetylpiperazin- 1-yl)acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00556## N-[[6-[4-[(5-methyltetrazol-1- yl)methyl]benzoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00557## N-[[6-(pyridine-4-carbonyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00558## N-[[6-(pyridine-2-carbonyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00559## N-[[6-(oxazole-4-carbonyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00560## N-[[6-(1H-1,2,4-triazole-3- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00561## N-[[6-(1H-imidazole-4- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00562## N-[[6-(pyrimidine-4- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00563## N-[[6-(pyridine-3-carbonyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00564## N-[[6-(1H-pyrazole-3- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00565## N-[[6-(1-methylimidazole-4- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00566## N-[[6-(3-methyl-1H- pyrazole-4-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00567## N-[[6-(2-methylpyrazole-3- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00568## N-[[6-(5-methyl-1H- pyrazole-3-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00569## N-[[6-(1-methylpyrazole-3- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00570## N-[[6-(pyridazine-3- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00571## N-[[6-(pyrimidine-5- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00572## N-[[6-(pyrazine-2-carbonyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00573## N-[[6-(pyridazine-4- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00574## N-[[6-(1-methylpyrazole-4- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00575## N-[[6-(1,5-dimethylpyrazole- 3-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00576## N-[[6-(2,5-dimethylpyrazole- 3-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00577## N-[[6-(5-methylisoxazole-3- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00578## N-[[6-(4-methyl-1,2,5- oxadiazole-3-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00579## N-[[6-(2-methylpyridine-3- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00580## N-[[6-(4-methylpyridine-3- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00581## N-[[6-(2-methylpyridine-4- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00582## N-[[6-(5-methylpyrazine-2- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00583## N-[[6-(3-cyclopropyl-1H- pyrazole-5-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00584## N-[[6-(1-ethyl-5-methyl- pyrazole-4-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00585## N-[[6-(3,5- dimethylisoxazole-4- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00586## N-[[6-(1-ethylpyrazole-4- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00587## N-[[6-(6-cyanopyridine-3- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00588## N-[[6-(2,4-dimethyloxazole- 5-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00589## N-[[6-(2-morpholinopyridine- 4-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00590## N-[[6- (cyclopropanecarbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00591## N-[[6-[1-methyl-5- (trifluoromethyl)pyrazole-3- carbonyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00592## N-[[6-(4-isoxazol-5-yl-1- methyl-pyrazole-3- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00593## N-[[6-(2-acetamidopyridine- 4-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00594## N-[[6-[3-(tetrazol-1-yl)-1H- pyrazole-4-carbonyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00595## N-[[6-(6-acetamidopyridine- 2-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00596## N-[[6-(3-ethyl-5-methyl- isoxazole-4-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00597## N-[[6-(2-ethyl-5-methyl- pyrazole-3-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00598## N-[[6-(1-ethyl-3-methyl- pyrazole-4-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00599## N-[[6-(3-methylisoxazole-4- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00600## N-[[6-[2-methyl-3-(3- methylpyrazol-1- yl)propanoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00601## N-[[6-(1H-pyrazole-4- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00602## N-[[6-[2-(1-methylsulfonyl-4- piperidyl)acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00603## N-[[6-(4-methylmorpholine- 2-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00604## N-[[6-[1-(2- methylpropanoyl)azetidine- 3-carbonyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00605## N-[[6-(1-acetylazetidine-3- carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00606## N-[[6-(1-pyridazin-3- ylpyrrolidine-3-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00607## N-[[6-[2-(1-pyrimidin-2-yl-4- piperidyl)acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00608## N-[[6-[2-(1-isopropyl-4- piperidyl)acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00609## N-[[6-[2-(1-methyl-4- piperidyl)acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide ##STR00610## N-[[6-[2-(3-methyloxetan-3- yl)acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00611## isopropyl 2-[(1,3- dihydropyrrolo[3,4- c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00612## N-[[6-[2-(2- cyanophenyl)acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00613## N-[[6-(3-methoxypropanoyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00614## N-[[6-[2-[4- (trifluoromethylsulfonyl) phenyl]acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00615## N-[[6-[3- [acetyl(methyl)amino]propanoyl]- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00616## N-[[6-[2-(2-pyridyl)acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00617## N-[[6-[(4- cyanophenyl)carbamoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00618## N-[[6-(m- tolylmethylcarbamoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00619## N-[[6-(p-tolylcarbamoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00620## N-[[6-(benzylcarbamoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00621## N-[[6-[(2- fluorophenyl)methylcarbamoyl]- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00622## N-[[6-(p- tolylmethylcarbamoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine- 2-carboxamide; ##STR00623## N-[[6-(m-tolylmethylcarbamoyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00624## N-[[6-(p-tolylcarbamoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00625## N-[[6-(benzylcarbamoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide;

##STR00626## N-[[6-[(2- fluorophenyl)methylcarbamoyl]- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00627## N-[[6-(p-tolylmethylcarbamoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00628## N-[[6-[(4- fluorophenyl)methylcarbamoyl]- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00629## N-[[6-[(2- methoxyphenyl)methylcarbamoyl]- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00630## N-[[6-[(3- methoxyphenyl)methylcarbamoyl]- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00631## N-[[6-[(3- fluorophenyl)methylcarbamoyl]- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00632## N-[[6-[(4- methoxyphenyl)methylcarbamoyl]- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00633## N-[[6-[(3,4- dichlorophenyl)methylcarbamoyl]- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00634## N-[[6-(1-adamantylcarbamoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00635## N-[[6-[(4- chlorophenyl)methylcarbamoyl]- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00636## N-[[6-[(2- chlorophenyl)methylcarbamoyl]- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00637## N-[[6-(ethylcarbamoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00638## N-[[6-[(2,4- dichlorophenyl)methylcarbamoyl]- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00639## N-[[6-[2-(3-hydroxy-3-methyl- cyclobutyl)acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00640## N-[[6-[2-(3-methyloxetan-3- yl)acetyl]-6-azaspiro[2.5]octan-2- yl]methyl]-1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00641## N-[[6-[2-(2-pyridyl)acetyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00642## N-[[6-[2-(3-pyridyl)acetyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00643## N-[[6-[2-(3-cyanophenyl)acetyl]- 6-azaspiro[2.5]octan-2- yl]methyl]-1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00644## N-[[6-[4-(1,2,4-triazol-1- yl)benzoyl]-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00645## N-[[6-[2-(2-methylimidazol-1- yl)acetyl]-6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00646## N-[[6-(1,3,5-trimethylpyrazole-4- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00647## N-[[6-(tert-butylcarbamoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00648## N-[[6-(isopropylcarbamoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00649## N-[[6- (cyclohexylmethylcarbamoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00650## N-[[6-(propylcarbamoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00651## N-[[6-(cyclohexylcarbamoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00652## N-[[6-(phenylcarbamoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00653## N-[[6-[2-(1-isopropyl-4- piperidyl)acetyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00654## N-[[6-(3-methylbutanoyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00655## N-[[6-[2-(4-pyridyl)acetyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00656## N-[[6-(2-cyanoacetyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00657## ethyl 2-[(1,3-dihydropyrrolo[3,4- c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00658## tert-butyl 2-[(1H-pyrrolo[3,2- c]pyridine-2- carbonylamino)methyl]-7- azaspiro[3.5]nonane-7- carboxylate; ##STR00659## tert-butyl 2-[(furo[2,3-c]pyridine- 2-carbonylamino)methyl]-7- azaspiro[3.5]nonane-7- carboxylate; ##STR00660## N-[[6-[2-(3-methyloxetan-3- yl)acetyl]-6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00661## N-[[6-(2-cyclohexylacetyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00662## N-[[6-(3-cyclohexylpropanoyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00663## N-[[6-(2-morpholinoacetyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00664## N-[[6-(3-phenylpropanoyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00665## tert-butyl 2-[(1,3- dihydropyrrolo[3,4-c]pyridine-2- carbonylamino)methyl]-7- azaspiro[3.5]nonane-7- carboxylate; ##STR00666## N-[[6-[2-(3,5- difluorophenyl)acetyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00667## N-[[6-[2-[3- (trifluoromethyl)phenyl]acetyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00668## N-[[6-(tert-butylcarbamoyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide; ##STR00669## [2.2,2-trideuterio-1,1- bis(trideuteriomethyl)ethyl] 2- [(1,3-dihydropyrrolo[3,4- c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00670## (2-methoxy-1,1-dimethyl-2-oxo- ethyl) 2-[(furo[2,3-c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00671## N-[[6-[2-(3-cyanophenyl)acetyl]- 6-azaspiro[2.5]octan-2- yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00672## N-[[6-[2-(4-cyanophenyl)acetyl]- 6-azaspiro[2.5]octan-2- yl]methyl]-1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00673## N-[[6-(phenylcarbamoyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00674## N-[[6-[3-(3-pyridyl)propanoyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00675## N-[[6-(benzylcarbamoyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00676## N-[(6-benzylsulfonyl-6- azaspiro[2.5]octan-2-yl)methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00677## N-[[6-(tert-butylcarbamoyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00678## N-[[6-(3,3-dimethylbutanoyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide; ##STR00679## N-[[6-(3,3-dimethylbutanoyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide; ##STR00680## (2-hydroxy-1,1-dimethyl-ethyl) 2- [(furo[2,3-c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00681## N-[[6-[2-(4-cyanophenyl)acetyl]- 6-azaspiro[2.5]octan-2- yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00682## (2-methoxy-1,1-dimethyl-ethyl) 2-[(1,3-dihydropyrrolo[3,4- c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00683## N-[[6-(2-tetrahydropyran-4- ylacetyl)-6-azaspiro[2.5]octan-2- yl]methyl]-1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00684## N-[[6-(1,3,5-trimethylpyrazole-4- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]-1,3- dihydropyrrolo[3,4-c]pyridine-2- carboxamide; ##STR00685## N-[[6-(1-methylpyrazole-4- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]-1,3- dihydropyrrolo[3,4-c]pyridine-2- carboxamide; ##STR00686## N-[[6-(1-isopropyl-3,5-dimethyl- pyrazole-4-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00687## N-[[6-[1-(4-fluorophenyl)-3.5- dimethyl-pyrazole-4-carbonyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00688## (1-methylcyclobutyl) 2-[(1,3- dihydropyrrolo[3,4-c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00689## N-[[6-(3-morpholinopropanoyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00690## N-[[6-(2,2-difluoro-2-phenyl- acetyl)-6-azaspiro[2.5]octan-2- yl]methyl]-1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00691## N-[[6-(3-methylpyridine-2- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00692## N-[[6-(3-methylpyridine-4- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00693## N-[[6-(6-methylpyridine-3- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00694## N-[[6-(6-methylpyridine-2- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00695## N-[[6-(4-methylpyridine-2- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00696## N-[[6-(1H-benzimidazole-4- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00697## N-[[6-(pyrrolo[1,2-c]pyrimidine-3- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00698## N-[[6-(1H-benzotriazole-5- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide;

##STR00699## N-[[6-(1H-pyrrolo[2,3-b]pyridine- 4-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00700## N-[[6-(1H-indazole-4-carbonyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00701## N-[[6-(1H-benzimidazole-5- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00702## N-[[6-(4-cyanobenzoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00703## N-[[6-(3-cyanobenzoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00704## N-[[6-[4-[(5-methyl-1,2,4- oxadiazol-3-yl)methoxy]benzoyl]- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00705## N-[[6-[4- (morpholinomethyl)benzoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00706## N-[[6-[4-[(2-methylimidazol-1- yl)methyl]benzoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00707## N-[[6-[4- (trifluoromethoxy)benzoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00708## N-[[6-[4-(pyrrolidin-1- ylmethyl)benzoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00709## N-[[6-[3-(1,2,4-triazol-1- ylmethyl)benzoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00710## N-[[6-[2-(1,2,4-triazol-1- ylmethyl)benzoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00711## N-[[6-[4-(1,2,4-triazol-1- ylmethyl)benzoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00712## N-[[6-[3-(imidazol-1- ylmethyl)benzoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00713## N-[[6-(4-imidazol-1-ylbenzoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00714## N-[[6-[4-(1H-1,2,4-triazol-5- yl)benzoyl]-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00715## N-[[6-(6-imidazol-1-ylpyridine-3- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00716## N-[[6-[4-(trifluoromethyl)pyridine- 2-carbonyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00717## N-[[6-[6-(trifluoromethyl)pyridine- 3-carbonyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00718## N-[[6-(3-oxo-4H-1,4- benzoxazine-6-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00719## N-[[6-(4-sulfamoylbenzoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00720## N-[[6-[2-(imidazol-1- ylmethyl)benzoyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00721## N-[[6-(quinoxaline-6-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00722## N-[[6-(1,6-naphthyridine-2- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00723## N-[[6-(2-methyl-1H- benzimidazole-5-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00724## N-[[6-(3-acetamidobenzoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00725## N-[[6-(3-acetamidopyridine-4- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00726## N-[[6-(2,1,3-benzoxadiazole-5- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00727## N-[[6-(1,8-naphthyridine-4- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00728## N-[[6-(isoquinoline-5-carbonyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00729## N-[[6-(quinoxaline-2-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00730## N-[[6-(1,5-naphthyridine-2- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00731## N-[[6-(1,8-naphthyridine-2- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00732## N-[[6-(isoxazole-5-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00733## N-[[6-(3-methylbutanoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00734## tert-butyl 2-[(4,6-dihydro-1H- pyrrolo[3,4-c]pyrazole-5- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00735## N-[[6-[2-(1,4-dimethyl-4- piperidyl)acetyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00736## N-[[6-[2-(3-hydroxy-3-methyl- cyclobutyl)acetyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00737## N-[[6-[2-(3-pyridyl)acetyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide; ##STR00738## N-[[6-[2-(4-pyridyl)acetyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide; ##STR00739## N-[[6-(1,3-dimethylpyrazole-4- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]-1,3- dihydropyrrolo[3,4-c]pyridine-2- carboxamide; ##STR00740## N-[[6-[4-(2-methyltetrazol-5- yl)benzoyl]-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00741## N-[[6-(4,6-dimethylpyridine-3- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00742## N-[[6-(4-oxopentanoyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2 carboxamide; ##STR00743## N-[[6-(4-hydroxy-4-methyl- pentanoyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00744## N-[[6-(3-hydroxy-3-methyl- butanoyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00745## N-[[6-[2-(2-pyridyl)acetyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide; ##STR00746## N-[[6-(2-pyrimidin-2-ylacetyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00747## N-[[6-(2-pyrazin-2-ylacetyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00748## N-[[6-(3-thiazol-2-ylpropanoyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00749## N-[[6-(2-phenoxyacetyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00750## N-[[6-(3-tetrahydropyran-4- ylpropanoyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00751## N-[[6-(4-methylpyridine-3- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00752## N-[[6-(3,5-dimethyl-1H-pyrazole- 4-carbonyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00753## N-[[6-(1,3,5-trimethylpyrazole-4- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00754## N-[[6-(1-tert-butyl-3,5-dimethyl- pyrazole-4-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00755## N-[[6-(1-benzyl-3,5-dimethyl- pyrazole-4-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00756## N-[[6-(5-tert-butyl-2-methyl- pyrazole-3-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00757## N-[[6-(2-ethylpyrazole-3- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00758## N-[[6-(2-tert-butyl-4-methyl- pyrazole-3-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00759## N-[[6-(2,4-dimethylpyrazole-3- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00760## N-[[6-(1,3,5-trimethylpyrazole-4- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00761## N-[[6-(1,3,5-trimethylpyrazole-4- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00762## N-[[6-(1H-indazole-3-carbonyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00763## N-[[6-[1-(1-isopropylpyrrolidin-3- yl)pyrazole-4-carbonyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00764## N-[[6-[1-(1-acetylpyrrolidin-3- yl)pyrazole-4-carbonyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00765## N-[[6-[5-(1,3-dimethylpyrazol-4- yl)isoxazole-3-carbonyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00766## tert-butyl 3-[2-[(furo[2,3- c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6-carbonyl]- 4,6-dihydro-1H-pyrrolo[3,4- c]pyrazole-5-carboxylate; ##STR00767## N-[[6-[1-(1-methylpyrrolidin-3- yl)pyrazole-4-carbonyl]-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00768## N-[[6-(2-tert-butyl-5-methyl- pyrazole-3-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00769## N-[[6-(2-methylimidazo[1,2- a]pyridine-3-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00770## N-[[6-(6-methyl-1H- benzimidazole-2-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00771## N-[[6-(5-methylimidazo[1,2- a]pyridine-2-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00772## N-[[6-(6-fluoro-1H-indazole-3- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00773## N-[[6-(pyrazolo[1,5-a]pyrimidine- 2-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00774## N-[[6-(1-ethyl-3,5-dimethyl- pyrazole-4-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide;

##STR00775## N-[[6-(6-methylimidazo[1,2- a]pyridine-2-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00776## N-[[6-(imidazo[1,2-a]pyridine-2- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00777## N-[[6-(5-isopropylisoxazole-4- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00778## N-[[6-(3-isobutyl-1H-pyrazole-5- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00779## N-[[6-(imidazo[1,2-a]pyrimidine- 2-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00780## N-[[6-(pyrazolo[1,5-a]pyrimidine- 3-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00781## N-[[6-(3-tert-butyl-1H-pyrazole-5- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00782## N-[[6-(5-isopropyl-1H-pyrazole- 3-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00783## N-[[6-(3-isopropyl-1H-pyrazole- 4-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00784## N-[[6-(2-isopropylpyrazole-3- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00785## N-[[6-(5-ethyl-2-methyl-pyrazole- 3-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00786## N-[[6-(5-cyclopropylisoxazole-3- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00787## N-[[6-(5-cyclopropylisoxazole-4- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00788## N-[[6-(3,5-dimethyl-1H-pyrazole- 4-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00789## N-[[6-(1,5-dimethylpyrazole-4- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00790## N-[[6-(4-methyloxazole-5- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00791## N-[[6-(3-cyclopropyl-1H- pyrazole-4-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00792## N-[[6-(1,4,5,6- tetrahydrocyclopenta[c]pyrazole- 3-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00793## N-[[6-(2,5-dimethyloxazole-4- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00794## N-[[6-(1,3-dimethylpyrazole-4- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00795## N-[[6-(oxazole-5-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00796## N-[[6-(isoxazole-4-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00797## N-[[6-(1H-imidazole-2-carbonyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00798## N-[[6-[4-(4-methylpiperazin-1- yl)benzoyl]-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00799## N-[[6-(3H-imidazo[4,5-b]pyridine- 6-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00800## N-[[6-(5-methylpyridine-2- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00801## N-[[6-[4-[(4-methylpiperazin-1- yl)methyl]benzoyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide; ##STR00802## N-[[6-[3-[(4-methylpiperazin-1- yl)methyl]benzoyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide; ##STR00803## N-[[6-[4- [(dimethylamino)methyl]benzoyl]- 6-azaspiro[2.5]octan-2- yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00804## N-[[6-[4-[(4-methylpiperazin-1- yl)methyl]benzoyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00805## N-[[6-(1,5-dimethylpyrazole-4- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]-1,3- dihydropyrrolo[3,4-c]pyridine-2- carboxamide; ##STR00806## N-[[6-(2,2- dimethylcyclopropanecarbonyl)- 6-azaspiro[2.5]octan-2- yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00807## (3-methyloxetan-3-yl) 2-[(1,3- dihydropyrrolo[3,4-c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00808## (2-hydroxy-1,1-dimethyl-ethyl) 2- [(1,3-dihydropyrrolo[3,4- c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00809## N-[[6-(4-methylpyridine-3- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]-1,3- dihydropyrrolo[3,4-c]pyridine-2- carboxamide; ##STR00810## N-[[6-(3-cyclopropyl-1H- pyrazole-5-carbonyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00811## N-[[6-(4-isoxazol-5-yl-1-methyl- pyrazole-3-carbonyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00812## N-[[6-(2,4-dimethyloxazole-5- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]-1,3- dihydropyrrolo[3,4-c]pyridine-2- carboxamide; ##STR00813## N-[[6-[2-(1,4-dimethyl-4- piperidyl)acetyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00814## N-[[6-[2-(2-cyanophenyl)acetyl]- 6-azaspiro[2.5]octan-2- yl]methyl]-1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00815## (2-acetamido-1,1-dimethyl-ethyl) 2-[(1,3-dihydropyrrolo[3,4- c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00816## N-[[6-(2-thiazol-2-ylacetyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00817## N-[[6-(4-hydroxy-4-methyl- pentanoyl)-6-azaspiro[2.5]octan- 2-yl]methyl]-1,3- dihydropyrrolo[3,4-c]pyridine-2- carboxamide; ##STR00818## N-[[6-[(3-methyloxetan-3- yl)carbamoyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00819## N-[[6-[4-(4-methylpiperazin-1- yl)benzoyl]-6-azaspiro[2.5]octan- 2-yl]methyl]-1,3- dihydropyrrolo[3,4-c]pyridine-2- carboxamide; ##STR00820## N-[[6-[4-(4-methylpiperazin-1- yl)benzoyl]-6-azaspiro[2.5]octan- 2-yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00821## N-[[6-(2,2- dimethylcyclopropanecarbonyl)- 6-azaspiro[2.5]octan-2- yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00822## N-[[6-(1,3,5-trimethylpyrazole-4- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]-1,3- dihydropyrrolo[3,4-c]pyridine-2- carboxamide; ##STR00823## N-[[6-(1,3,5-trimethylpyrazole-4- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]-1,3- dihydropyrrolo[3,4-c]pyridine-2- carboxamide; ##STR00824## tert-butyl 2-[[(1,1,3,3- tetradeuteriopyrrolo[3,4- c]pyridine-2- carbonyl)amino]methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00825## N-[[6-(3-cyclopropyl-1H- pyrazole-5-carbonyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide; ##STR00826## N-[[6-(4-isoxazol-5-yl-1-methyl- pyrazole-3-carbonyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide; ##STR00827## N-[[6-(2,4-dimethyloxazole-5- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00828## N-[[6-(2,2- dimethylcyclopropanecarbonyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00829## N-[[6-[4-(4-methylpiperazine-1- carbonyl)benzoyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00830## N-[[6-(2,2- dimethylcyclopropanecarbonyl)- 6-azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00831## (3-methyltetrahydrofuran-3-yl) 2- [(1,3-dihydropyrrolo[3,4- c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00832## (2-hydroxy-2-methyl-propyl) 2- [(1,3-dihydropyrrolo[3,4- c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00833## N-[[6-(2,2- dimethylcyclopropanecarbonyl)- 6-azaspiro[2.5]octan-2- yl]methyl]-1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00834## N-[[6-(2,2- dimethylpropylsulfonyl)-6- azaspiro[2.5]octan-2- yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00835## N-[[6-(2,2- dimethylpropylsulfonyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide; ##STR00836## N-[[6-(2,2- dimethylpropylsulfonyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00837## N-[[6-(4,4,4-trifluorobutanoyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00838## tert-butyl 2-[(pyrazolo[1,5- b]pyridazine-5- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00839## N-[[6-(2,4-dimethyloxazole-5- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00840## N-[[6-(2,4-dimethyloxazole-5- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00841## N-[[6-[2-(2-hydroxy-2-methyl- propoxy)acetyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide; ##STR00842## N-[[6-[2-methyl-4- (trifluoromethyl)thiazole-5- carbonyl]-6-azaspiro[2.5]octan- 2-yl]methyl]-1,3- dihydropyrrolo[3,4-c]pyridine-2- carboxamide;

##STR00843## N-[[6-(2,2- dimethylcyclopropanecarbonyl)- 6-azaspiro[2.5]octan-2- yl]methyl]-1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00844## tert-butyl 2-[(imidazo[1,2- a]pyridin-6- ylmethylcarbamoylamino)methyl]- 6-azaspiro[2.5]octane-6- carboxylate; ##STR00845## N-[[6-[2-(2-hydroxy-2-methyl- propoxy)acetyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00846## N-[[6-[2-(6-amino-3- pyridyl)acetyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00847## N-[[6-(morpholine-4-carbonyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00848## N-[[6-[5-(trifluoromethyl)-1H- pyrazole-3-carbonyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00849## N-[[6-(4-hydroxy-4-methyl- pentanoyl)-6-azaspiro[2.5]octan- 2-yl]methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide; ##STR00850## N-[[6-[4-(trifluoromethyl)pyridine- 3-carbonyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00851## N-[[6-[2-(4- methyltetrahydropyran-4- yl)acetyl]-6-azaspiro[2.5]octan-2- yl]methyl]-1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00852## N-[[6-[2-(3-hydroxy-3-methyl- cyclobutyl)acetyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide; ##STR00853## (2-hydroxy-2-methyl-propyl) 2- [(1H-pyrrolo[3,2-c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00854## tert-butyl 2-[(imidazo[1,2- b]pyridazine-6- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00855## N-[[6-[2-[4-methyl-1-(2,2,2- trifluoroethyl)-4-piperidyl]acetyl]- 6-azaspiro[2.5]octan-2- yl]methyl]-1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00856## N-[[6-(2,4-dimethylthiazole-5- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]-1,3- dihydropyrrolo[3,4-c]pyridine-2- carboxamide; ##STR00857## N-[[6-[4-(1-methyl-4- piperidyl)benzoyl]-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00858## tert-butyl 2-[[(6-amino-1,3- dihydropyrrolo[3,4-c]pyridine-2- carbonyl)amino]methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00859## N-[[6-(2-pyrimidin-5-ylacetyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00860## 1,1,3,3-tetradeuterio-N-[[6-(3- methylbutanoyl)-6- azaspiro[2.5]octan-2- yl]methyl]pyrrolo[3,4-c]pyridine- 2-carboxamide; ##STR00861## (3-methyloxetan-3-yl) 2- [[(1,1,3,3- tetradeuteriopyrrolo[3,4- c]pyridine-2- carbonyl)amino]methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00862## 1,1,3,3-tetradeuterio-N-[[6-(2,4- dimethyloxazole-5-carbonyl)-6- azaspiro[2.5]octan-2- yl]methyl]pyrrolo[3,4-c]pyridine- 2-carboxamide; ##STR00863## N-[(6-benzoyl-6- azaspiro[2.5]octan-2- yl)methyl]furo[2,3-c]pyridine-2- carboxamide; ##STR00864## N-[[(2S)-6-(3-methylbutanoyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00865## N-[[(2R)-6-(3-methylbutanoyl)-6- azaspiro[2.5]octan-2-yl]methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; ##STR00866## N-[[6-(4-methyloxazole-5- carbonyl)-6-azaspiro[2.5]octan- 2-yl]methyl]-1,3- dihydropyrrolo[3,4-c]pyridine-2- carboxamide; ##STR00867## isopropyl 2-[(furo[2,3-c]pyridine- 2-carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00868## (3-methyloxetan-3-yl) 2- [(furo[2,3-c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate; ##STR00869## N-[(6-benzoyl-6- azaspiro[2.5]octan-2-yl)methyl]- 1,3-dihydropyrrolo[3,4- c]pyridine-2-carboxamide; and ##STR00870## (3-methyloxetan-3-yl) (2S)-2- [(1,3-dihydropyrrolo[3,4- c]pyridine-2- carbonylamino)methyl]-6- azaspiro[2.5]octane-6- carboxylate;

and stereoisomers thereof, and pharmaceutically acceptable salts of such compounds and stereoisomers.

15. A compound selected from the group consisting of: 1,1,3,3-tetradeuterio-N-[[6-(2,4-dimethyloxazole-5-carbonyl)-6-azaspiro[2- .5]octan-2-yl]methyl]pyrrolo[3,4-c]pyridine-2-carboxamide, (3-methyloxetan-3-yl) 2-[[(1,1,3,3-tetradeuteriopyrrolo[3,4-c]pyridine-2-carbonyl)amino]methyl]- -6-azaspiro[2.5]octane-6-carboxylate; 1,1,3,3-tetradeuterio-N-[[6-(3-methylbutanoyl)-6-azaspiro[2.5]octan-2-yl]- methyl]pyrrolo[3,4-c]pyridine-2-carboxamide, N-[[6-[3-[(4-methylpiperazin-1-yl)methyl]benzoyl]-6-azaspiro[2.5]octan-2-- yl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide, N-[[6-(isoxazole-4-carbonyl)-6-azaspiro[2.5]octan-2-yl]methyl]furo[2,3-c]- pyridine-2-carboxamide, N-[[6-(imidazo[1,2-a]pyridine-2-carbonyl)-6-azaspiro[2.5]octan-2-yl]methy- l]furo[2,3-c]pyridine-2-carboxamide,N-[[6-(1,8-naphthyridine-4-carbonyl)-6- -azaspiro[2.5]octan-2-yl]methyl]furo[2,3-c]pyridine-2-carboxamide, N-[[6-[4-(2-methyltetrazol-5-yl)benzoyl]-6-azaspiro[2.5]octan-2-yl]methyl- ]furo[2,3-c]pyridine-2-carboxamide, N-[[6-[4-(2-methyltetrazol-5-yl)benzoyl]-6-azaspiro[2.5]octan-2-yl]methyl- ]furo[2,3-c]pyridine-2-carboxamide, N-[[6-[4-(2-methyltetrazol-5-yl)benzoyl]-6-azaspiro[2.5]octan-2-yl]methyl- ]furo[2,3-c]pyridine-2-carboxamide, (3-methyloxetan-3-yl) (2S)-2-[(1,3-dihydropyrrolo[3,4-c]pyridine-2-carbonylamino)methyl]-6-azas- piro[2.5]octane-6-carboxylate, N-[[6-[4-(2-methyltetrazol-5-yl)benzoyl]-6-azaspiro[2.5]octan-2-yl]methyl- ]furo[2,3-c]pyridine-2-carboxamide, N-[[6-(2,4-dimethyloxazole-5-carbonyl)-6-azaspiro[2.5]octan-2-yl]methyl]-- 1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide, N-[[6-[4-[(4-methylpiperazin-1-yl)methyl]benzoyl]-6-azaspiro[2.5]octan-2-- yl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide, N-[[6-(3-cyclopropyl-1H-pyrazole-5-carbonyl)-6-azaspiro[2.5]octan-2-yl]me- thyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide, N-[[6-(3-methylbutanoyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyr- rolo[3,4-c]pyridine-2-carboxamide, N-[[(2S)-6-(3-methylbutanoyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihyd- ropyrrolo[3,4-c]pyridine-2-carboxamide, N-[[6-(2-isopropylpyrazole-3-carbonyl)-6-azaspiro[2.5]octan-2-yl]methyl]f- uro[2,3-c]pyridine-2-carboxamide, N-[[6-(pyrrolo[1,2-c]pyrimidine-3-carbonyl)-6-azaspiro[2.5]octan-2-yl]met- hyl]furo[2,3-c]pyridine-2-carboxamide, N-[[(2S)-6-(3-methylbutanoyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihyd- ropyrrolo[3,4-c]pyridine-2-carboxamide, N-[[6-(pyrazine-2-carbonyl)-6-azaspiro[2.5]octan-2-yl]methyl]furo[2,3-c]p- yridine-2-carboxamide, N-[[(2R)-6-(3-methylbutanoyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihyd- ropyrrolo[3,4-c]pyridine-2-carboxamide, N-[[6-(1,3,5-trimethylpyrazole-4-carbonyl)-6-azaspiro[2.5]octan-2-yl]meth- yl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide, N-[[6-(2,2-dimethylpropylsulfonyl)-6-azaspiro[2.5]octan-2-yl]methyl]furo[- 2,3-c]pyridine-2-carboxamide, and stereoisomers thereof, and pharmaceutically acceptable salts of such compounds and stereoisomers.

16. A compound comprising N-[[6-(1,3,5-trimethylpyrazole-4-carbonyl)-6-azaspiro[2.5]octan-2-yl]meth- yl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide, or stereoisomers thereof, or pharmaceutically acceptable salts of such compounds thereof.

17. A compound comprising N-[[6-(imidazo[1,2-a]pyridine-2-carbonyl)-6-azaspiro[2.5]octan-2-yl]methy- l]furo[2,3-c]pyridine-2-carboxamide, or stereoisomers thereof, or pharmaceutically acceptable salts of such compounds thereof.

18. A compound comprising N-[[6-(3-methylbutanoyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyr- rolo[3,4-c]pyridine-2-carboxamide, or stereoisomers thereof, or pharmaceutically acceptable salts of such compounds thereof.

19. A compound comprising N-[[6-[3-[(4-methylpiperazin-1-yl)methyl]benzoyl]-6-azaspiro[2.5]octan-2-- yl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide, or stereoisomers thereof, or pharmaceutically acceptable salts of such compounds thereof.

20. A compound comprising N-[[6-(1,8-naphthyridine-4-carbonyl)-6-azaspiro[2.5]octan-2-yl]methyl]fur- o[2,3-c]pyridine-2-carboxamide, or stereoisomers thereof, or pharmaceutically acceptable salts of such compounds thereof.

21. A compound comprising N-[[6-(isoxazole-4-carbonyl)-6-azaspiro[2.5]octan-2-yl]methyl]furo[2,3-c]- pyridine-2-carboxamide, or stereoisomers thereof, or pharmaceutically acceptable salts of such compounds thereof.

22. A compound comprising (3-methyloxetan-3-yl) 2-[(1,3-dihydropyrrolo[3,4-c]pyridine-2-carbonylamino)methyl]-6-azaspiro[- 2.5]octane-6-carboxylate, or stereoisomers thereof, or pharmaceutically acceptable salts of such compounds thereof.

23. A compound comprising N-[[6-[4-[(4-methylpiperazin-1-yl)methyl]benzoyl]-6-azaspiro[2.5]octan-2-- yl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide, or stereoisomers thereof, or pharmaceutically acceptable salts of such compounds thereof.

24. A compound comprising N-[[6-(3-cyclopropyl-1H-pyrazole-5-carbonyl)-6-azaspiro[2.5]octan-2-yl]me- thyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide, or stereoisomers thereof, or pharmaceutically acceptable salts of such compounds thereof.

25. A compound comprising N-[[6-(2-isopropylpyrazole-3-carbonyl)-6-azaspiro[2.5]octan-2-yl]methyl]f- uro[2,3-c]pyridine-2-carboxamide, or stereoisomers thereof, or pharmaceutically acceptable salts of such compounds thereof.

26. A compound comprising N-[[6-[4-(2-methyltetrazol-5-yl)benzoyl]-6-azaspiro[2.5]octan-2-yl]methyl- ]furo[2,3-c]pyridine-2-carboxamide, or stereoisomers thereof, or pharmaceutically acceptable salts of such compounds thereof.

27. A compound comprising N-[[6-(2,4-dimethyloxazole-5-carbonyl)-6-azaspiro[2.5]octan-2-yl]methyl]-- 1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide, or stereoisomers thereof, or pharmaceutically acceptable salts of such compounds thereof.

28. A compound comprising N-[[6-(pyrrolo[1,2-c]pyrimidine-3-carbonyl)-6-azaspiro[2.5]octan-2-yl]met- hyl]furo[2,3-c]pyridine-2-carboxamide, or stereoisomers thereof, or pharmaceutically acceptable salts of such compounds thereof.

29. A compound comprising N-[[6-(2,2-dimethylpropylsulfonyl)-6-azaspiro[2.5]octan-2-yl]methyl]furo[- 2,3-c]pyridine-2-carboxamide, or stereoisomers thereof, or pharmaceutically acceptable salts of such compounds thereof.

30. A compound comprising N-[[6-(pyrazine-2-carbonyl)-6-azaspiro[2.5]octan-2-yl]methyl]furo[2,3-c]p- yridine-2-carboxamide, or stereoisomers thereof, or pharmaceutically acceptable salts of such compounds thereof.

31. A pharmaceutical composition comprising: (a) an effective amount of at least one compound of claim 27; and (b) a pharmaceutically acceptable carrier.

32. The pharmaceutical composition of claim 31, further comprising a rescuing agent selected from the group consisting of nicotinamide, nicotinic acid, and nicotinamide mononucleotide (NMN), or therapeutically effective amounts of one or more additional adjunctive active agents, wherein said one or more additional adjunctive active agents are selected from the group consisting of cytotoxic agent, cisplatin, doxorubicin, taxotere, taxol, etoposide, irinotecan, camptostar, topotecan, paclitaxel, docetaxel, the epothilones, tamoxifen, 5-fluorouracil, methoxtrexate, temozolomide, cyclophosphamide, SCH 66336, tipifarnib (Zarnestra.RTM.), R115777, L778,123, BMS 214662, Iressa.RTM., Tarceva.RTM., C225, GLEEVEC.RTM., Intron.RTM., Peg-Intron.RTM., aromatase combinations, ara-C, adriamycin, cytoxan, gemcitabine, Uracil mustard, Chlormethine, Ifosfamide, Melphalan, Chlorambucil, Pipobroman, Triethylenemelamine, Triethylenethiophosphoramine, Busulfan, Carmustine, Lomustine, Streptozocin, Dacarbazine, Floxuridine, Cytarabine, 6-Mercaptopurine, 6-Thioguanine, Fludarabine phosphate, oxaliplatin, leucovirin, oxaliplatin (ELOXATIN.RTM.), Pentostatine, Vinblastine, Vincristine, Vindesine, Bleomycin, Dactinomycin, Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mithramycin.TM., Deoxycoformycin, Mitomycin-C, L-Asparaginase, Teniposide 17.alpha.-Ethinylestradiol, Diethylstilbestrol, Testosterone, Prednisone, Fluoxymesterone, Dromostanolone propionate, Testolactone, Megestrol acetate, Methylprednisolone, Methyltestosterone, Prednisolone, Triamcinolone, Chlorotrianisene, Hydroxyprogesterone, Aminoglutethimide, Estramustine, Medroxyprogesteroneacetate, Leuprolide, Flutamide, Toremifene, goserelin, Carboplatin, Hydroxyurea, Amsacrine, Procarbazine, Mitotane, Mitoxantrone, Levamisole, Navelbene, Anastrazole, Letrazole, Capecitabine, Reloxafine, Droloxafine, Hexamethylmelamine, Avastin, herceptin, Bexxar, Velcade, Zevalin, Trisenox, Xeloda, Vinorelbine, Porfimer, Erbitux, Liposomal, Thiotepa, Altretamine, Melphalan, Trastuzumab, Lerozole, Fulvestrant, Exemestane, Ifosfomide, Rituximab, C225, Campath, leucovorin, and dexamethasone, bicalutamide, carboplatin, chlorambucil, cisplatin, letrozole, megestrol, valrubicin, vinblastine and NIASPAN.RTM..

33. A method of treating a subject suffering from or diagnosed with a medical condition mediated by NAMPT activity, comprising administering to the subject in need of such treatment an effective amount of at least one compound of claim 1.

34. The method of claim 33, wherein the medical condition is ovarian cancer, breast cancer, and cervical cancer.

35. The method of claim 33, further comprising administering to the subject an effective amount of a rescuing agent selected from the group consisting of nicotinamide, nicotinic acid, and nicotinamide mononucleotide (NMN), or at least one compound selected from the group consisting of: a cytotoxic agent, cisplatin, doxorubicin, taxotere, taxol, etoposide, irinotecan, camptostar, topotecan, paclitaxel, docetaxel, the epothilones, tamoxifen, 5-fluorouracil, methoxtrexate, temozolomide, cyclophosphamide, SCH 66336, tipifarnib (Zarnestra.RTM.), R115777, L778,123, BMS 214662, Iressa.RTM., Tarceva.RTM., C225, GLEEVEC.RTM., Intron.RTM., Peg-Intron.RTM., aromatase combinations, ara-C, adriamycin, cytoxan, gemcitabine, Uracil mustard, Chlormethine, Ifosfamide, Melphalan, Chlorambucil, Pipobroman, Triethylenemelamine, Triethylenethiophosphoramine, Busulfan, Carmustine, Lomustine, Streptozocin, Dacarbazine, Floxuridine, Cytarabine, 6-Mercaptopurine, 6-Thioguanine, Fludarabine phosphate, leucovirin, oxaliplatin (ELOXATIN.RTM.), Pentostatine, vincristine, Vindesine, Bleomycin, Dactinomycin, Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mithramycin.TM., Deoxycoformycin, Mitomycin-C, L-Asparaginase, Teniposide 17.alpha.-Ethinylestradiol, Diethylstilbestrol, Testosterone, Prednisone, Fluoxymesterone, Dromostanolone propionate, Testolactone, Megestrol acetate, Methylprednisolone, Methyltestosterone, Prednisolone, Triamcinolone, Chlorotrianisene, Hydroxyprogesterone, Aminoglutethimide, Estramustine, Medroxyprogesteroneacetate, Leuprolide, Flutamide, Toremifene, goserelin, Carboplatin, Hydroxyurea, Amsacrine, Procarbazine, Mitotane, Mitoxantrone, Levamisole, Navelbene, Anastrazole, Letrazole, Capecitabine, Reloxafine, Droloxafine, Hexamethylmelamine, Avastin, herceptin, Bexxar, Velcade, Zevalin, Trisenox, Xeloda, Vinorelbine, Porfimer, Erbitux, Liposomal, Thiotepa, Altretamine, Melphalan, Trastuzumab, Lerozole, Fulvestrant, Exemestane, Ifosfomide, Rituximab, C225, Campath, leucovorin, dexamethasone, bicalutamide, chlorambucil, letrozole, megestrol, valrubicin, vinblastine, and NIASPAN.RTM..

Summary for Patent:   Start Trial

PCT Information
PCT FiledMarch 01, 2013PCT Application Number:PCT/CN2013/000216
PCT Publication Date:September 06, 2013PCT Publication Number:WO2013/127269

Details for Patent 9,822,129

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Genentech, Inc. (South San Francisco, CA) Forma TM, LLC (Watertown, MA) 2032-03-02 RX search
Genentech RITUXAN rituximab VIAL 103705 001 1997-11-26   Start Trial Genentech, Inc. (South San Francisco, CA) Forma TM, LLC (Watertown, MA) 2032-03-02 RX Orphan search
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial Genentech, Inc. (South San Francisco, CA) Forma TM, LLC (Watertown, MA) 2032-03-02 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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