Claims for Patent: 8,999,979
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Summary for Patent: 8,999,979
Title: | Compound useful for the treatment of degenerative and inflammatory diseases |
Abstract: | A novel compound able to inhibit JAK is disclosed, that is according to Formula I: ##STR00001## or a pharmaceutically acceptable salt thereof. The compound may be prepared as a pharmaceutical composition, and may be used for the treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6. |
Inventor(s): | Menet; Christel Jeanne Marie (Mechelen, BE), Smits; Koen Kurt (Mechelen, BE) |
Assignee: | Galapagos NV (Mechelen, BE) |
Application Number: | 14/026,027 |
Patent Claims: | 1. A method for the treatment of inflammatory bowel disease (IBD), comprising administering an amount of a compound according to Formula I: ##STR00031## or a
pharmaceutically acceptable salt thereof, sufficient to effect said treatment.
2. The method according to claim 1, wherein the compound according to Formula I is administered in combination with a further therapeutic agent. 3. A method for the treatment of inflammatory bowel disease (IBD), comprising administering an amount of a pharmaceutical composition comprising a pharmaceutically acceptable carrier and an amount of a compound according to Formula I: ##STR00032## or a pharmaceutically acceptable salt thereof, sufficient to effect said treatment. 4. The method according to claim 2, wherein the further therapeutic agent is an agent for the treatment of inflammatory bowel disease (IBD). 5. The method according to claim 3, wherein the further therapeutic agent is an agent for the treatment of inflammatory bowel disease (IBD). 6. The method according to claim 4, wherein the further therapeutic agent is an agent selected from glucocorticoids, synthetic disease modifying, immunomodulatory agents and biological disease modifying, immunomodulatory agents. 7. The method according to claim 5, wherein the further therapeutic agent is an agent selected from glucocorticoids, synthetic disease modifying, immunomodulatory agents and biological disease modifying, immunomodulatory agents. 8. The method according to claim 6, wherein the further therapeutic agent is selected from prednisone, budesonide, methotrexate, leflunomide, sulfasalazine, mesalazine, azathioprine, 6-mercaptopurine, cyclosporine, infliximab, adalimumab, rituximab, and abatacept. 9. The method according to claim 7, wherein the further therapeutic agent is selected from prednisone, budesonide, methotrexate, leflunomide, sulfasalazine, mesalazine, azathioprine, 6-mercaptopurine, cyclosporine,infliximab, adalimumab, rituximab, and abatacept. 10. The method according to claim 1, wherein the inflammatory bowel disease is Crohn's disease. 11. The method according to claim 3, wherein the inflammatory bowel disease is Crohn's disease. 12. The method according to claim 1, wherein the inflammatory bowel disease is colitis. 13. The method according to claim 3, wherein the inflammatory bowel disease is colitis. |
Details for Patent 8,999,979
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Genentech, Inc. | RITUXAN | rituximab | Injection | 103705 | 11/26/1997 | ⤷ Try a Trial | 2029-06-26 |
Idec Pharmaceuticals Corp. | RITUXAN | rituximab | Injection | 103737 | 02/19/2002 | ⤷ Try a Trial | 2029-06-26 |
Janssen Biotech, Inc. | REMICADE | infliximab | For Injection | 103772 | 08/24/1998 | ⤷ Try a Trial | 2029-06-26 |
Abbvie Inc. | HUMIRA | adalimumab | Injection | 125057 | 12/31/2002 | ⤷ Try a Trial | 2029-06-26 |
Abbvie Inc. | HUMIRA | adalimumab | Injection | 125057 | 02/21/2008 | ⤷ Try a Trial | 2029-06-26 |
Abbvie Inc. | HUMIRA | adalimumab | Injection | 125057 | 04/24/2013 | ⤷ Try a Trial | 2029-06-26 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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