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Last Updated: April 26, 2024

Claims for Patent: 7,951,786


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Summary for Patent: 7,951,786
Title:Method of treating inflammatory arthropathies with suppressors of CpG oligonucleotides
Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating inflammatory arthropathies by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
Inventor(s): Klinman; Dennis (Potomac, MD), Zeuner; Rainald (Kiel, DE), Verthelyi; Daniela (Potomac, MD), Gursel; Ihsan (Rockville, MD), Gursel; Mayda (Rockville, MD)
Assignee: The United States of America as represented by the Department of Health and Human Services (Washington, DC) N/A (N/A)
Application Number:12/325,106
Patent Claims:1. A method of treating or preventing an inflammatory arthropathy in a subject comprising: administering to a subject having or at risk of developing the inflammatory arthropathy a therapeutically effective amount of an oligodeoxynucleotide comprising the oligodeoxynucleotide sequence set forth as SEQ ID NO: 1, thereby suppressing an immune response in the subject and treating or preventing the inflammatory arthropathy in the subject.

2. The method of claim 1, wherein the oligodeoxynucleotide is administered topically, parenterally, orally, intravenously, intra-muscularly, sub-cutaneously, or intra-articularly.

3. The method of claim 1, wherein the oligodeoxynucleotide is from 16 to 100 nucleotides in length.

4. The method of claim 1, wherein the oligodeoxynucleotide is from 16 to 30 nucleotides in length.

5. The method of claim 1, further comprising administering an additional anti-inflammatory, immunosuppressive, or anti-arthritis agent.

6. The method of claim 5, wherein the agent is a biological response modifier, a disease-modifying antirheumatic drug, a steroid, a nonsteroidal anti-inflammatory drug, or a Cyclo-Oxygenase-2 inhibitor.

7. The method of claim 5, wherein the agent is anakinra, etanercept, infliximab, leflunomide, prednisone, cortisone, celecoxib, choline magnesium trisalicylate, diclofenac, diclofenac potassium, diclofenac XR, diflunisal, etodolac, etodolac ER, fenoprofen, flurbiprofen oral, ibuprofen, indomethacin, indomethacin SR, indomethacin suppositories, ketoprofen, ketoprofen ER, meclofenamate, meloxicam, nabumetone, naproxen, naproxen CR, naproxen ER, oxaprozin, piroxicam, rofecoxib, salsalate, sulindac, or tolmetin sodium, hyaluronan, or hylan G-F20.

8. The method of claim 1, wherein the oligodeoxynucleotide consists of the nucleic acid sequence set forth as SEQ ID NO: 1.

9. The method of claim 1, wherein the oligodeoxynucleotide is administered systemically.

10. A method of treating inflammatory arthropathy in a subject comprising contacting immune cells with a therapeutically effective amount of an oligodeoxynucleotide of 16 to 30 nucleotides in length, wherein the oligodeoxynucleotide comprises the nucleotide sequence set forth as SEQ ID NO: 1 and transferring the immune cells to a subject having or at risk of developing inflammatory arthropathy, thereby treating the inflammatory arthropathy.

11. The method of claim 10, wherein the immune cells are transplanted.

12. The method of claim 10, wherein the immune cells are transferred intravenously.

13. The method of claim 10, wherein the oligodeoxynucleotide consists of the nucleic acid sequence set forth as SEQ ID NO: 1.

Details for Patent 7,951,786

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Janssen Biotech, Inc. REMICADE infliximab For Injection 103772 08/24/1998 ⤷  Try a Trial 2022-08-01
Immunex Corporation ENBREL etanercept For Injection 103795 11/02/1998 ⤷  Try a Trial 2022-08-01
Immunex Corporation ENBREL etanercept For Injection 103795 05/27/1999 ⤷  Try a Trial 2022-08-01
Immunex Corporation ENBREL etanercept Injection 103795 09/27/2004 ⤷  Try a Trial 2022-08-01
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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