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Last Updated: April 26, 2024

Claims for Patent: 7,713,521


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Summary for Patent: 7,713,521
Title:MCP1 fusions
Abstract: The present invention provides polypeptides including MCP1 fused, optionally, by a linker, to an immunoglobulin. Methods for using the polypeptides to treat medical disorders are also covered.
Inventor(s): Chou; Chuan-Chu (Westfield, NJ), Bober; Loretta A. (Linden, NJ), Sullivan; Lee (Somerset, NJ)
Assignee: Schering Corporation (Kenilworth, NJ)
Application Number:11/502,064
Patent Claims:1. An isolated polypeptide comprising a human MCP1 polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 2 fused to a human immunoglobulin gamma-1 polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 7.

2. The polypeptide of claim 1 comprising one mature MCP1 polypeptide fused to one immunoglobulin.

3. The polypeptide of claim 2 wherein the MCP1 is fused to the immunoglobulin by a peptide linker consisting of the amino acid sequence Glycine-Serine.

4. A pharmaceutical composition comprising the polypeptide of claim 3 and a pharmaceutically acceptable carrier.

5. A composition comprising the polypeptide of claim 3 in association with one or more further therapeutic agents or a pharmaceutical composition thereof.

6. The composition of claim 5 wherein the further therapeutic agent is a member selected from the group consisting of aspirin, diclofenac, diflunisal, etodolac, fenoprofen, floctafenine, flurbiprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, meclofenamate, mefenamic acid, meloxicam, nabumetone, naproxen, oxaprozin, phenylbutazone, piroxicam, salsalate, sulindac, tenoxicam, tiaprofenic acid, tolmetin, betamethasone benzoate, betamethasone valerate, clobetasol propionate, desoximetasone, fluocinolone acetonide, flurandrenolide, a topical steroid, alclometasone dipropionate, aloe vera, amcinonide, amcinonide, anthralin, betamethasone dipropionate, betamethasone valerate, calcipotriene, clobetasol propionate, coal tar, Dead Sea salts, desonide, desonide; betamethasone valerate, desoximetasone, diflorasone diacetate, epsom salts, fluocinolone acetonide, fluocinonide, flurandrenolide, fluticasone propionate, halcinonide, halobetasol propionate, hydrocortisone valerate, hydrocortisone, mometasone furoate, oilated oatmeal, petroleum jelly, prednicarbate, salicylic acid, tazarotene, triamcinolone acetonide, a mixture of hydrocortisone, dexamethasone, methylprednisolone and prednisolone, alefacept, etanercept, cyclosporine, methotrexate, acitretin, isotretinoin, hydroxyurea, mycophenolate mofetil, sulfasalazine, 6-Thioguanine, anakinra, injectable gold, penicillamine, azathioprine, chloroquine, hydroxychloroquine, sulfasalazine, oral gold, auranofin, gold sodium thiomalate, aurothioglucose, mesalamine, sulfasalazine, budesonide, metronidazole, ciprofloxacin, azathioprine, 6-mercaptopurine or dietary supplementation of calcium, folate, vitamin B12, celecoxib, rofecoxib, valdecoxib, lumiracoxib, etoricoxib, efalizumab, adalimumab, infliximab and ABX-IL8.

7. An isolated polypeptide produced by a method comprising transforming a host cell with an expression vector comprising a polynucleotide encoding a polypeptide of claim 1 under conditions suitable for said expression and, optionally, isolating the polypeptide from the host cell.

8. The polypeptide of claim 1 wherein MCP1 is fused to the immunoglobulin by a peptide linker.

Details for Patent 7,713,521

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Janssen Biotech, Inc. REMICADE infliximab For Injection 103772 08/24/1998 ⤷  Try a Trial 2025-08-12
Immunex Corporation ENBREL etanercept For Injection 103795 11/02/1998 ⤷  Try a Trial 2025-08-12
Immunex Corporation ENBREL etanercept For Injection 103795 05/27/1999 ⤷  Try a Trial 2025-08-12
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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