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Last Updated: April 26, 2024

Claims for Patent: 7,344,716

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Summary for Patent: 7,344,716

Title:	Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
Abstract:	The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
Inventor(s):	DiMauro; Thomas M. (Southboro, MA), Serhan; Hassan (South Easton, MA), Attawia; Mohamed (Canton, MA)
Assignee:	DePuy Spine, Inc. (Raynham, MA)
Application Number:	10/456,948
Patent Claims:	1. A method of treating degenerative disc disease in an intervertebral disc having a nucleus pulposus and an annulus fibrosus, comprising the steps of: a) transdiscally administering an effective amount of a formulation comprising a high specificity cytokine antagonist into an intervertebral disc, wherein the antagonist is a monoclonal antibody that inhibits TNF-.alpha.. 2. The method of claim 1 wherein the monoclonal antibody is infliximab. 3. The method of claim 1 wherein the monoclonal antibody is etanercept. 4. The method of claim 1 wherein the high specificity cytokine antagonist is present in the formulation in a concentration of at least 100 mg/ml.

Details for Patent 7,344,716

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Janssen Biotech, Inc.	REMICADE	infliximab	For Injection	103772	08/24/1998	⤷ Try a Trial	2023-05-13
Immunex Corporation	ENBREL	etanercept	For Injection	103795	11/02/1998	⤷ Try a Trial	2023-05-13
Immunex Corporation	ENBREL	etanercept	For Injection	103795	05/27/1999	⤷ Try a Trial	2023-05-13
Immunex Corporation	ENBREL	etanercept	Injection	103795	09/27/2004	⤷ Try a Trial	2023-05-13
Immunex Corporation	ENBREL	etanercept	Injection	103795	02/01/2007	⤷ Try a Trial	2023-05-13
Immunex Corporation	ENBREL MINI	etanercept	Injection	103795	09/14/2017	⤷ Try a Trial	2023-05-13
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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