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Serving hundreds of leading biopharmaceutical companies globally:

Chinese Patent Office
Fuji
Dow
AstraZeneca
Baxter
McKesson
Federal Trade Commission
Moodys
McKinsey

Generated: June 21, 2018

DrugPatentWatch Database Preview

VALCHLOR Drug Profile

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When do Valchlor patents expire, and what generic alternatives are available?

Valchlor is a drug marketed by Actelion Pharms Ltd and is included in one NDA. There are six patents protecting this drug.

This drug has twenty-seven patent family members in seventeen countries.

The generic ingredient in VALCHLOR is mechlorethamine hydrochloride. There is one drug master file entry for this compound. Two suppliers are listed for this compound. Additional details are available on the mechlorethamine hydrochloride profile page.
Summary for VALCHLOR
Drug patent expirations by year for VALCHLOR
Pharmacology for VALCHLOR
Drug ClassAlkylating Drug
Mechanism of ActionAlkylating Activity
Medical Subject Heading (MeSH) Categories for VALCHLOR
Synonyms for VALCHLOR
.Beta.,.beta.'-Dichlorodiethyl-N-methylamine
055M867
1, 5-Dichloro-3-methyl-3-azapentane hydrochloride
126-85-2 (N-oxide)
13159-EP2277876A1
13159-EP2292614A1
13159-EP2295426A1
13159-EP2295427A1
13159-EP2308833A2
13159-EP2308861A1
13159-EP2311825A1
13159-EP2311842A2
13159-EP2316834A1
13159-EP2374454A1
2-chloro-N-(2-chloroethyl)-N-methyl-ethanamine
2-Chloro-N-(2-chloroethyl)-N-methylethanamine
2,2'-Dichloro-N-me
2,2'-Dichloro-N-methyldiethylamine
2,2'-Dichlorodiethyl-methylamine
302-70-5 (N-oxide, hydrochloride)
49304-EP2272827A1
49304-EP2311840A1
50D9XSG0VR
51-75-2
55-86-7 (HYDROCHLORIDE)
A8064
AB00052033_05
AB00052033-04
AC1L1H9H
AK111499
AKOS006229862
AN-41618
Antimit
BDBM200297
beta,beta'-Dichlorodiethyl-N-methylamine
bis-(2-chloro-ethyl)-methyl-amine
bis-(2-chloro-ethyl)-methylamine
Bis-(2-chloroethyl)methylamine
Bis(.beta.-chloroethyl)methylamine
bis(2-chloro-ethyl)-methyl-amine
bis(2-chloroethyl)(methyl)amine
Bis(2-chloroethyl)methylamine
Bis(b-chloroethyl)methylamine
Bis(beta-chloroethyl) methylamine
Bis(beta-chloroethyl)methylamine
bis(chloroethyl)methylamine
BRN 0605323
BSPBio_001947
C07115
C5H11Cl2N
Carolysine
Caryolysin
Caryolysin (Salt/Mix)
Caryolysine
Caryolysine (Salt/Mix)
CCG-39885
CCRIS 447
CHEBI:28925
CHEMBL427
Chloramine (the nitrogen mustard)
Chlorethazine
Chlormethine
Chlormethine (INN)
Chlormethine [INN:BAN]
Chlormethinehydrochloride
Chlormethinum [INN-Latin]
cid_4033
Cloramin
Clormetina
Clormetina [INN-Spanish]
D03SSE
D07671
DB00888
Di(2-chloroethyl)methylamine
Dichlor amine
Dichloren
Dichloren (Salt/Mix)
Diethylamine, 2,2'-dichloro-N-methyl-
DivK1c_000759
DTXSID2020975
EINECS 200-120-5
Embechine
Embichin
Embichin (Salt/Mix)
ENT-25294
Epitope ID:116224
Eraso (Salt/Mix)
Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-
GTPL7218
HAWPXGHAZFHHAD-UHFFFAOYSA-N
HMS1920J15
HMS2091B04
HMS502F21
HN-2
HN2
Hn2 (amine)
HSDB 5083
I14-8708
IBS-L0033631
IDI1_000759
KBio1_000759
KBio2_001369
KBio2_003937
KBio2_006505
KBio3_001447
KBioGR_001448
KBioSS_001369
LS-7559
MBA
MCULE-6341452542
Me chloroethamine
Mebichloramine
mechlorethamine
Mechlorethanamine
Mechloroethamine
Mecloretamina
Mecloretamina [Italian]
Methyl-bis(2-chloroethyl)amine
Methylbis(.beta.-chloroethyl)amine
Methylbis(2-chloroethyl)amine
Methylbis(beta-chloroethyl)amine
Methylchlorethamine
Methyldi(2-chloroethyl)amine
Mitoxine (*Hydrochloride*)
Mustargen
Mustargen (TN)
Mustine
Mustine note
Mutagen
N-Lost
N-Methyl lost
N-Methyl-2,2'-dichlorodiethylamine
N-Methyl-bis-chloraethylamin
N-Methyl-bis-chloraethylamin [German]
N-Methyl-bis(.beta.-chloroethyl)amine
N-Methyl-bis(2-chloroethyl)amine
N-Methyl-bis(beta-chloroethyl)amine
N-METHYL-DI(2-CHLORO)-ETHYLAMINE
N-Methyl-lost
N-Methyl-lost [German]
N-methylbis(2-chloroethyl)amine
N-methyldi-(2-chloroethyl)amine
N,N-Bis(2-chloroethyl)-N-methylamine
N,N-Bis(2-chloroethyl)-N-methylamine #
N,N-Bis(2-chloroethyl)methylamine
N,N-Di(chloroethyl)methylamine
NCGC00091835-02
NCGC00091835-03
NCGC00091835-04
NCGC00091835-05
NCGC00091835-06
NCGC00091835-07
NCGC00091835-08
NCGC00091835-09
NCI60_041682
NINDS_000759
Nitol (*Hydrochloride*)
Nitol (Salt/Mix)
Nitrogen mustard
Nitrogen mustard (HN-2)
Nitrogranulogen
NSC 762
NSC-757087
NSC-762
NSC757087
OR041104
OR276818
Pharmakon1600-01500375
SBI-0051432.P003
SCHEMBL3861
SPBio_000496
Spectrum_000889
SPECTRUM1500375
Spectrum2_000448
Spectrum3_000484
Spectrum4_000924
Spectrum5_001702
Stickstofflost (*Hydrochloride*)
Stickstofflost (ebewe)
STL484282
T 1024
T-1024
thyldiethylamine
TL 146
U601
UNII-50D9XSG0VR
ZINC2539484

US Patents and Regulatory Information for VALCHLOR

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Actelion Pharms Ltd VALCHLOR mechlorethamine hydrochloride GEL;TOPICAL 202317-001 Aug 23, 2013 RX Yes Yes ➤ Sign Up ➤ Sign Up ➤ Sign Up
Actelion Pharms Ltd VALCHLOR mechlorethamine hydrochloride GEL;TOPICAL 202317-001 Aug 23, 2013 RX Yes Yes ➤ Sign Up ➤ Sign Up ➤ Sign Up
Actelion Pharms Ltd VALCHLOR mechlorethamine hydrochloride GEL;TOPICAL 202317-001 Aug 23, 2013 RX Yes Yes ➤ Sign Up ➤ Sign Up Y ➤ Sign Up
Actelion Pharms Ltd VALCHLOR mechlorethamine hydrochloride GEL;TOPICAL 202317-001 Aug 23, 2013 RX Yes Yes ➤ Sign Up ➤ Sign Up ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration

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Non-Orange Book US Patents for VALCHLOR

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
2,010,029,783 ➤ Sign Up
8,664,278 Stabilized compositions of volatile alkylating agents and methods of using thereof ➤ Sign Up
8,501,817 Stabilized compositions of alkylating agents and methods of using same ➤ Sign Up
Patent No. Title Estimated Patent Expiration

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Supplementary Protection Certificates for VALCHLOR

Supplementary Protection Certificate SPC Country SPC Expiration SPC Description
/2017 Austria ➤ Sign Up PRODUCT NAME: CHLORMETHIN; REGISTRATION NO/DATE: EU/1/16/1171 (MITTEILUNG) 20170307
2017 00033 Denmark ➤ Sign Up PRODUCT NAME: CHLORMETHINE, HERUNDER CHLORMETHINE HYDROCHLORIDE; REG. NO/DATE: EU/1/16/1171 20170307
0888 Netherlands ➤ Sign Up PRODUCT NAME: CHLORMETHINE, ALSMEDE DE THERAPEUTISCH EQUIVALENTE VARIANTEN ER VAN ZOALS BESCHERMD DOOR HET BASISOCTROOI; REGISTRATION NO/DATE: EU/1/16/1171 20170307
2017000059 Germany ➤ Sign Up PRODUCT NAME: CHLORMETHIN; REGISTRATION NO/DATE: EU/1/16/1171 20170303
Supplementary Protection Certificate SPC Country SPC Expiration SPC Description

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Serving hundreds of leading biopharmaceutical companies globally:

Mallinckrodt
QuintilesIMS
Fuji
Teva
Argus Health
Baxter
Merck
UBS
US Army

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