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Last Updated: November 19, 2019

DrugPatentWatch Database Preview

TRINTELLIX Drug Profile

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Which patents cover Trintellix, and what generic alternatives are available?

Trintellix is a drug marketed by Takeda Pharms Usa and is included in one NDA. There are ten patents protecting this drug and one Paragraph IV challenge.

This drug has two hundred and four patent family members in forty-one countries.

The generic ingredient in TRINTELLIX is vortioxetine hydrobromide. There are sixteen drug master file entries for this compound. Two suppliers are listed for this compound. Additional details are available on the vortioxetine hydrobromide profile page.

Drug patent expirations by year for TRINTELLIX
Drug Prices for TRINTELLIX

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Drug Sales Revenue Trends for TRINTELLIX

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Generic Entry Opportunity Date for TRINTELLIX
Generic Entry Date for TRINTELLIX*:
Constraining patent/regulatory exclusivity:
NDA:
Dosage:
TABLET;ORAL

*The generic entry opportunity date is the latter of the last compound-claiming patent and the last regulatory exclusivity protection. Many factors can influence early or later generic entry. This date is provided as a rough estimate of generic entry potential and should not be used as an independent source.

Recent Clinical Trials for TRINTELLIX

Identify potential brand extensions & 505(b)(2) entrants

SponsorPhase
Noam SoreniPhase 3
University of CataniaPhase 4
Azienda Ospedaliera Universitaria Integrata VeronaPhase 4

See all TRINTELLIX clinical trials

Recent Litigation for TRINTELLIX

Identify potential future generic entrants

District Court Litigation
Case NameDate
H. Lundbeck A/S v. Apicore US LLC2018-07-12
H. Lundbeck A/S v. MSN Laboratories Private Limited2018-06-07
H. Lundbeck A/S v. Lupin Limited2018-05-21

See all TRINTELLIX litigation

Synonyms for TRINTELLIX
1-(2-((2,4-Dimethylphenyl)sulfanyl)phenyl)piperazine monohydrobromide
1-(2-((2,4-Dimethylphenyl)sulfanyl)phenyl}piperazine
1-(2-((2,4-Dimethylphenyl)thio)phenyl)piperazine
1-(2-((2,4-Dimethylphenyl)thio)phenyl)piperazine hydrobromide
1-(2-((2,4-DIMETHYLPHENYL)THIO)PHENYL)PIPERAZINE HYDROCHLRIDE
1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine
1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine
1-[2-(2,4-Dimethylphenylsulfanyl)-phenyl]piperazine
1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine
1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-hbr
1-[2-[(2,4-Dimethylphenyl)thio]phenyl]piperazine
1-[2-[(2,4-dimethylphenyl)thio]phenyl]piperazine hydrobromide
1-{2-[(2,4-dimethylphenyl)sulfanyl]phenyl}piperazine
1-{2-[(2,4-dimethylphenyl)sulfanyl]phenyl}piperazine hydrobromide
2796AH
3O2K1S3WQV
4-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]-piperazine hydrobromide
4-{2-[(2,4-dimethylphenyl)sulfanyl]phenyl}piperazin-1-ium bromide
4CH-016292
508233-74-7
7034AB
960203-27-4
A3926
AB0165485
AC-27648
AC-28325
AJ-86685
AKOS016008748
AKOS016340374
API0019472
AX8224799
BCP05996
BCP09588
BDBM50400902
Brintellix
Brintellix (TN)
C18H22N2S.BrH
CCG-229998
CHEBI:76015
CHEBI:76016
CHEMBL2104993
CHEMBL2107387
CHEMBL2204360
CS-1471
CS-1472
D10184
D10185
DA-42264
EBD3080710
EX-A2348
FT-0686961
FT-0696676
GG-0052
GTPL7351
HG-0011
HSDB 8250
HY-15414
HY-15414A
KB-81458
KB-81459
KS-0000062Y
Lu AA 21004 hydrobromide
Lu AA 21004 hydrobromide;Lu AA21004 hydrobromide
Lu AA 21004 pound>>LuAA21004 pound>> Lu-AA21004 pound>> Lu AA21004 pound>> AA21004
Lu AA 21004|||1-[2-[(2,4-dimethylphenyl)thio]phenyl]-piperazine
Lu AA 21004|||1-[2-[(2,4-dimethylphenyl)thio]phenyl]-piperazine hydrobromide
Lu AA21004
Lu AA21004 (HBr)
Lu-AA-21004
Lu-AA21004-(HBr)
MolPort-023-298-791
MolPort-023-298-793
PIP107
Piperazine, 1-(2-((2,4-dimethylphenyl)thio)phenyl)-
Piperazine, 1-(2-((2,4-dimethylphenyl)thio)phenyl)-, hydrobromide (1:1)
Piperazine, 1-[2-[(2,4-dimethylphenyl)thio]phenyl]-
s8021
SB16506
SB16507
SC-53652
SC-95551
SCHEMBL236115
SCHEMBL237653
ST2408515
STL483777
SW219360-1
TKS641KOAY
UNII-3O2K1S3WQV
UNII-TKS641KOAY
VNGRUFUIHGGOOM-UHFFFAOYSA-N
vortioxetina
VORTIOXETINE
Vortioxetine (hydrobromide)
Vortioxetine (Lu AA21004)
Vortioxetine (Lu AA21004) HBr
Vortioxetine (Lu AA21004) hydrobromide
Vortioxetine (USAN)
Vortioxetine [USAN:INN]
Vortioxetine HBr
Vortioxetine hydrobromide
Vortioxetine hydrobromide (JAN/USAN)
Vortioxetine hydrobromide [USAN]
vortioxetine monohydrobromide
Vortioxetine, Lu AA21004
vortioxetinum
W-5909
W-5911
YQNWZWMKLDQSAC-UHFFFAOYSA-N
ZINC34051848
Paragraph IV (Patent) Challenges for TRINTELLIX
Tradename Dosage Ingredient NDA Submissiondate
TRINTELLIX TABLET;ORAL vortioxetine hydrobromide 204447

US Patents and Regulatory Information for TRINTELLIX

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Takeda Pharms Usa TRINTELLIX vortioxetine hydrobromide TABLET;ORAL 204447-004 Sep 30, 2013 RX Yes Yes   Start Trial   Start Trial   Start Trial
Takeda Pharms Usa TRINTELLIX vortioxetine hydrobromide TABLET;ORAL 204447-003 Sep 30, 2013 DISCN Yes No   Start Trial   Start Trial   Start Trial
Takeda Pharms Usa TRINTELLIX vortioxetine hydrobromide TABLET;ORAL 204447-004 Sep 30, 2013 RX Yes Yes   Start Trial   Start Trial   Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Supplementary Protection Certificates for TRINTELLIX

Patent Number Supplementary Protection Certificate SPC Country SPC Expiration SPC Description
1436271 508 Finland   Start Trial
1436271 92397 Luxembourg   Start Trial PRODUCT NAME: VORTIOXETINE OU UN SEL D ADDITION D ACIDE DE CELUI-CI PHARMACEUTIQUEMENT ACCEPTABLE
1436271 C 2014 023 Romania   Start Trial PRODUCT NAME: VORTIOXETINA SAU O SARE DE ADITIE ACIDA A ACESTEIAACCEPTABILA FARMACEUTIC1-[2-(2,4-DIMETILFENILSULFANIL)FENIL]PIPERAZINA; NATIONAL AUTHORISATION NUMBER: EU/1/13/891; DATE OF NATIONAL AUTHORISATION: 20131218; NUMBER OF FIRST AUTHORISATION IN EUROPEAN ECONOMIC AREA (EEA): EU/1/13/891; DATE OF FIRST AUTHORISATION IN EEA: 20131218
>Patent Number >Supplementary Protection Certificate >SPC Country >SPC Expiration >SPC Description

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Serving leading biopharmaceutical companies globally:

McKinsey
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Johnson and Johnson
AstraZeneca
Boehringer Ingelheim
McKesson

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