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Generated: May 26, 2019

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SINEQUAN Drug Profile

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When do Sinequan patents expire, and what generic alternatives are available?

Sinequan is a drug marketed by Pfizer and is included in two NDAs.

The generic ingredient in SINEQUAN is doxepin hydrochloride. There are seven drug master file entries for this compound. Twenty-eight suppliers are listed for this compound. Additional details are available on the doxepin hydrochloride profile page.

Summary for SINEQUAN
Drug patent expirations by year for SINEQUAN
Medical Subject Heading (MeSH) Categories for SINEQUAN
Synonyms for SINEQUAN
(3-(6H-dibenzo[c,f]oxepin-11-ylidene)propyl)dimethylamine, chloride
(3E)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethyl-1-propanamine hydrochloride
(3E)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethyl-propan-1-amine hydrochloride
(3E)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine
(3E)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine hydrochloride
(3E)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine;hydrochloride
(3e)-3-(Dibenzo[b,E]oxepin-11(6h)-Ylidene)-N,N-Dimethylpropan-1-Amine
(3Z)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine hydrochloride
(E)-3-(Dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine
(e)-doxepin
(e)-doxepin hydrochloride
(Z)-3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine
(Z)-Doxepin hydrochloride
(Z)-N,N-Dimethyldibenz(b,e)oxepin-delta(sup 11(6H),gamma)-propylamine hydrochloride
[11C]-doxepin
[11C]doxepin
1-Propanamine, 3-dibenz(b,e)oxepin-11-(6H)-ylidene-N,N-dimethyl-dimethyl-, hydrochloride, (E)-
1-Propanamine, 3-dibenz(b,e)oxepin-11(6H)-ylidene-N,N-dimethyl-
1-Propanamine, 3-dibenz(b,e)oxepin-11(6H)-ylidene-N,N-dimethyl-, hydrochloride, (Z)-
1-Propanamine, 3-dibenz(b,e)oxepin-11(6H)ylidene-N,N-dimethyl-, hydrochloride
1-Propanamine, 3-dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-
1-Propanamine,e]oxepin-11(6H)-ylidene-N,N-dimethyl-, hydrochloride
1-Propanamine,e]oxepin-11(6H)ylidene-N,N-dimethyl-, hydrochloride
11-(3-(Dimethylamino)propylidene)-6,11-dihydrodibenz(b,e)oxepin hydrochloride
11-(3-(Dimethylamino)propylidene)-6H-dibenz(b,e)oxepine
11-(3-Dimethylamino-propyliden)-6,11-dihydro-dibenz(b,e)oxipin
11-(3-dimethylamino-propylidene)- 6,11-dihydrodibenzo- [b,e]-oxepine
11-(3-dimethylamino-propylidene)-6,11-dihydrodibenzo-[b,e]-oxepine
11-(3-Dimethylaminopropylidene)-6,11-dihydro-benz[b,e]Oxepin
11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz(b,e)oxipin
11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin hydrochloride
11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepine hydrochloride
11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo[b,e]oxepine Hydrochloride
11-(Dimethylamino)propylidene 6H-dibenz[b,e]oxepin
11-dimethylaminopropylidene6h-dibenz(b,e)oxepin
11[16h]-[3-(dimethylamino)-propylidene]dibenz[b,e]oxepine hydrochloride
1229-29-4
1668-19-5
20917-44-6
229D294
25127-31-5
25197-84-6
3-(6,11-Dihydrodibenz[b,e]oxepin-11-yliden)-N,N-dimethylpropylamin
3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethyl-propan-1-amine
3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine
3-(Dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine
3-Dibenz(b,c)oxepin 11(6H)ylidene-N,N-dimethyl-1-propanamine
3-dibenz(b,c)oxepin 11(6h)ylidene-n,n-dimethyl-1-propanamine hydrochloride
3607-34-9
4698-39-9
5EH
851NLB57HQ
A804993
AB0109368
AC-8076
AC1L1FAW
AC1LDI63
AC1NQY0E
AC1O4WGB
Adapin
AJ-08007
AKOS015895087
AKOS016014904
AKOS024458484
AKOS028110197
AN-20679
API0002487
Aponal
AS-13316
AX8126881
BC225584
BDBM112780
BDBM50225488
BG0175
BPBio1_000118
BRD-K36616567-003-01-5
BRD-K54462405-003-03-3
BRD-K54462405-003-16-5
BSPBio_000106
C-19460
C06971
C19H21NO
C19H21NO.HCl
CAS-1229-29-4
CCG-204434
CCG-220263
CCG-221643
CCG-38932
CCRIS 9176
CHEBI:4710
CHEBI:4711
CHEMBL1200462
CHEMBL1256774
CHEMBL1628227
CHEMBL860
Cidoxepin [INN]
Cidoxepin HCl
Cidoxepin hydrochloride
Cidoxepin hydrochloride (USAN)
Cidoxepin hydrochloride [USAN]
Cidoxepina
Cidoxepinum
cis-Doxepin hydrochloride
cis-N-(3-(6H-Dibenz(b,e)oxepin-11-yliden)propyl)-N,N-dimethylamin
CPD000058230
CPD000449270
CS-2972
CU61C5RH24
Curatin
D 4526
D00814
D03491
D07875
D4626
Deptran
Dibenz(b,e)oxepin-delta(sup 11(6H),gamma)-propylamine, N,N-dimethyl-, hydrochloride
Dibenz(b,e)oxepin-delta(sup 11(6H)),gamma-propylamine, N,N-dimethyl-
Dibenz(b,e)oxepin-delta11(6H),gamma-propylamine, N,N-dimethyl-, hydrochloride
Dibenz(b,e)oxepin-delta11(6H),gamma-propylamine, N,N-dimethyl-, hydrochloride (8CI)
Dibenz[b,.gamma.-propylamine, N,N-dimethyl-, hydrochloride
Dibenz[b,.gamma.)-propylamine, N,N-dimethyl-, hydrochloride
dimethyl({3-[(2E)-9-oxatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene]propyl})amine
dimethyl(3-{9-oxatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene}propyl)amine hydrochloride
dimethyl(3-{9-oxatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene}propyl)amine
DivK1c_000431
doxepin
Doxepin (Hydrochloride)
Doxepin (INN)
Doxepin (Z)-isomer hydrochloride
Doxepin [INN:BAN]
Doxepin [USAN]
Doxepin cis-form hydrochloride
Doxepin for system suitability, European Pharmacopoeia (EP) Reference Standard
Doxepin HCl
Doxepin Hydrochloride
Doxepin hydrochloride (E)-isomer
Doxepin hydrochloride (USP)
Doxepin hydrochloride [USAN:USP]
Doxepin Hydrochloride [USAN]
Doxepin Hydrochloride 1.0 mg/ml in Methanol (as free base)
Doxepin hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material
Doxepin Hydrochloride,
Doxepin hydrochloride, ~85% E-isomer basis, >=98% (GC), 15% Z-isomer basis, powder
Doxepin hydrochloride, European Pharmacopoeia (EP) Reference Standard
Doxepin hydrochloride, United States Pharmacopeia (USP) Reference Standard
Doxepin, (E)-
Doxepin, Hydrochloride
Doxepina
Doxepina [INN-Spanish]
Doxepine
Doxepine hydrochloride
Doxepinum
Doxepinum [INN-Latin]
DSSTox_CID_25145
DSSTox_GSID_45145
DSSTox_RID_80701
DTXSID7022966
DTXSID8045145
E-DOXEPIN
EINECS 214-966-8
EU-0100339
FT-0601521
GTPL1225
GTPL3958
H882
HMS1568F08
HMS1920I22
HSDB 3069
HY-B0725
I06-0502
J10288
Jsp001539
KB-233534
KBio1_000431
KBio2_001285
KBio2_003853
KBio2_006421
KBio3_001154
KBioGR_001131
KBioSS_001285
KS-5094
L000699
Lopac-D-4526
Lopac0_000339
LP00339
LS-174582
LS-61638
LS-61639
MF 10
MF 10 HCl
MFCD00079135
MLS000069794
MLS000758259
MLS001148235
MLS001423974
MLS002207250
MLS002222181
MLS002548858
MolPort-003-666-170
MolPort-003-872-120
N,e]oxepin-.delta. (sup11(6H),.gamma.)-propylamine hydrochloride
N,e]oxepin-.delta.-11(6H).gamma.-propylamine HCl
N,e]oxepin-.DELTA.11(6H),.gamma.-propylamine hydrochloride
N,e]oxepin-.DELTA.11(6H),.gamma.-propylamine, hydrochloride
N,N-Dimethyldibenz(b,e)oxepin-delta(11(6H),gamma)-propylamine
N,N-Dimethyldibenz(b,e)oxepin-delta(sup 11(6H),gamma)-propylamine hydrochloride
NC00052
NC00447
NCGC00015344-01
NCGC00015344-02
NCGC00015344-03
NCGC00015344-04
NCGC00015344-05
NCGC00024623-01
NCGC00024623-04
NCGC00093778-01
NCGC00093778-02
NCGC00094661-01
NCGC00094661-02
NCGC00162127-01
NCGC00261024-01
NINDS_000431
Novoxapin
Novoxapin hydrochloride
NSC-108160
NSC-756750
NSC108160
NSC756750
ODQWQRRAPPTVAG-UHFFFAOYSA-N
Opera_ID_675
Oprea1_473232
P 4599
P-3693A
P-4599
Pharmakon1600-01500264
Prestwick_187
Prestwick0_000263
Prestwick1_000263
Prestwick2_000263
Prestwick3_000263
Q-201044
Quitaxon
SAM001246976
SAM002264608
SBB005916
SC-62324
SCHEMBL116895
SCHEMBL124597
SCHEMBL28054
SCHEMBL60287
Silenor
Sinepin
Sinequan (TN)
Sinequan, Zonalon
Sinequin
SMR000058230
SMR000449270
SPBio_000206
SPBio_002325
Spectrum_000805
SPECTRUM1500264
Spectrum2_000133
Spectrum3_000407
Spectrum4_000526
SR-01000075551
SR-01000075551-1
SR-01000075551-5
SR-01000597760
SR-01000597760-1
ST025239
timtec-bb sbb005916
Tocris-0508
Toruan
Tox21_110130
Tox21_110130_1
Tox21_500339
trans-doxepin
trans-Doxepin hydrochloride
Triadapin
UNII-3U9A0FE9N5 component MHNSPTUQQIYJOT-CULRIWENSA-N
UNII-3U9A0FE9N5 component MHNSPTUQQIYJOT-SJDTYFKWSA-N
UNII-5ASJ6HUZ7D component ODQWQRRAPPTVAG-GZTJUZNOSA-N
UNII-851NLB57HQ
UNII-CU61C5RH24
UNII-XI27WMG8QK
US8629135, SW-07
WLN: T C676 IO&T&J B3N1&1 &GH
XI27WMG8QK
ZINC1331
Zonalon
Zonalon (TN)

US Patents and Regulatory Information for SINEQUAN

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Pfizer SINEQUAN doxepin hydrochloride CAPSULE;ORAL 016798-003 Approved Prior to Jan 1, 1982 DISCN Yes No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Pfizer SINEQUAN doxepin hydrochloride CONCENTRATE;ORAL 017516-001 Approved Prior to Jan 1, 1982 DISCN Yes No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Pfizer SINEQUAN doxepin hydrochloride CAPSULE;ORAL 016798-006 Approved Prior to Jan 1, 1982 DISCN Yes No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Pfizer SINEQUAN doxepin hydrochloride CAPSULE;ORAL 016798-001 Approved Prior to Jan 1, 1982 DISCN Yes No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration

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Expired US Patents for SINEQUAN

Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration
Pfizer SINEQUAN doxepin hydrochloride CONCENTRATE;ORAL 017516-001 Approved Prior to Jan 1, 1982 ➤ Sign Up ➤ Sign Up
Pfizer SINEQUAN doxepin hydrochloride CAPSULE;ORAL 016798-002 Approved Prior to Jan 1, 1982 ➤ Sign Up ➤ Sign Up
Pfizer SINEQUAN doxepin hydrochloride CAPSULE;ORAL 016798-003 Approved Prior to Jan 1, 1982 ➤ Sign Up ➤ Sign Up
Pfizer SINEQUAN doxepin hydrochloride CAPSULE;ORAL 016798-007 Approved Prior to Jan 1, 1982 ➤ Sign Up ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Healthtrust
Baxter
Boehringer Ingelheim
McKinsey
Mallinckrodt
Daiichi Sankyo

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