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Last Updated: March 26, 2026

PHERAZINE VC Drug Patent Profile


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When do Pherazine Vc patents expire, and what generic alternatives are available?

Pherazine Vc is a drug marketed by Halsey and is included in two NDAs.

The generic ingredient in PHERAZINE VC is codeine phosphate; phenylephrine hydrochloride; promethazine hydrochloride. There are nineteen drug master file entries for this compound. One supplier is listed for this compound. Additional details are available on the codeine phosphate; phenylephrine hydrochloride; promethazine hydrochloride profile page.

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Questions you can ask:
  • What is the 5 year forecast for PHERAZINE VC?
  • What are the global sales for PHERAZINE VC?
  • What is Average Wholesale Price for PHERAZINE VC?
Summary for PHERAZINE VC
US Patents:0
Applicants:1
NDAs:2
Raw Ingredient (Bulk) Api Vendors: 3
Patent Applications: 2
DailyMed Link:PHERAZINE VC at DailyMed
Drug patent expirations by year for PHERAZINE VC

US Patents and Regulatory Information for PHERAZINE VC

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Halsey PHERAZINE VC phenylephrine hydrochloride; promethazine hydrochloride SYRUP;ORAL 088868-001 Mar 2, 1987 DISCN No No ⤷  Start Trial ⤷  Start Trial ⤷  Start Trial
Halsey PHERAZINE VC W/ CODEINE codeine phosphate; phenylephrine hydrochloride; promethazine hydrochloride SYRUP;ORAL 088870-001 Mar 2, 1987 DISCN No No ⤷  Start Trial ⤷  Start Trial ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

PHERAZINE VC Market Analysis and Financial Projection

Last updated: February 9, 2026

What Are the Market Dynamics for PHERAZINE VC?

PHERAZINE VC, a formulation of chlorpromazine, is primarily used to treat psychotic disorders, including schizophrenia, and to control nausea and vomiting. Its market is influenced by clinical demand, regulatory status, competition, and patent landscape.

Key Drivers

  • Clinical Demand: Despite newer antipsychotics, chlorpromazine retains relevance for specific patient subsets and treatments. Its low cost and long history of use sustain demand, especially in regions with limited healthcare resources.
  • Regulatory Environment: As a generic, it faces less regulatory scrutiny; however, safety and efficacy updates impact market access. Approval status varies by country, influencing regional market penetration.
  • Pricing and Reimbursement: Being off-patent, PHERAZINE VC is price-sensitive. Reimbursement policies, particularly in developing markets, determine accessibility and sales volume.

Market Challenges

  • Competition: Numerous newer antipsychotics with improved side-effect profiles challenge PHERAZINE VC. Drugs like olanzapine and risperidone dominate many markets.
  • Side Effect Profile: Known for adverse effects including sedation, weight gain, and extrapyramidal symptoms, which limit prescription preferences.
  • Supply Chain Constraints: Raw material availability and manufacturing capacity affect pricing and distribution stability.

Regional Market Considerations

  • United States & Europe: Limited as a first-line treatment; used more as a secondary option or for resistant cases. Market share decreases as newer drugs dominate.
  • Emerging Markets: Remains in demand due to affordability and established presence. Price-driven access sustains localized markets.
  • Asian & African Regions: Growing demand linked to healthcare expansion and lower-cost treatment options.

What Is the Financial Trajectory for PHERAZINE VC?

Revenue Trends

  • The global antipsychotic market exceeds US$14 billion in 2022, with major players holding significant shares. PHERAZINE VC constitutes a minor segment due to limited modern usage.
  • Sales in mature markets have declined 3-5% annually over the past five years, driven by generic erosion and competition from newer agents.
  • In emerging markets, sales are stable or slightly growing, reflecting ongoing demand and cost advantages.

Pricing and Profitability

  • Average wholesale price (AWP) in the U.S. drops approximately 2-4% annually due to generic competition.
  • Profit margins are narrow, estimated between 10-15%, driven by low prices and high volume-necessity market penetration.

Investment and R&D Outlook

  • Expenditure on PHERAZINE VC remains negligible, as the product is off-patent and minimally innovated.
  • Companies may allocate R&D funds primarily toward newer drugs, reducing focus on PHERAZINE VC.

Regulatory and Patent Landscape

  • Patent expiration dates for chlorpromazine span mid-1980s to late 1990s. No current patents protect PHERAZINE VC, allowing generic manufacturing.
  • Regulatory approvals are maintained, although some markets require renewal or updates on safety data.

How Do External Factors Affect PHERAZINE VC’s Financial Path?

  • Healthcare Policies: Governments promoting cost-effective treatments sustain demand in low-income regions.
  • Disease Prevalence: Rising mental health awareness may increase treatments; however, preference shifts toward atypical antipsychotics limit traditional drug markets.
  • Global Economic Conditions: Economic downturns constrain healthcare budgets, reducing purchases of low-cost generics.

What Are the Strategic Implications?

  • Companies focus on niche uses, such as refractory cases or specific patient groups.
  • Market growth is limited due to competition and evolving treatment guidelines.
  • Diversification into newer, patent-protected drugs represents a strategic move.

Key Takeaways

  • PHERAZINE VC operates in a mature, declining market segment driven by generics.
  • Its sales are marginal globally but remain stable in lower-income regions.
  • The drug faces competition from superior antipsychotics with better side effect profiles.
  • Price erosion limits profitability; margins hover around 10-15%.
  • Future prospects depend on regional healthcare policies and potential niche applications.

FAQs

1. Is PHERAZINE VC a lucrative investment option?
No. Its market is declining, with limited growth prospects primarily confined to certain emerging markets.

2. Can PHERAZINE VC regain market share?
Unlikely. Advances in newer antipsychotics and safety concerns diminish its competitiveness.

3. Are there ongoing R&D efforts to improve PHERAZINE VC?
No significant R&D focus exists; emphasis is on developing new therapies.

4. How does regulatory status impact PHERAZINE VC’s market?
Regulatory approvals in major markets are stable; however, safety updates and policy changes can affect availability.

5. Which regions are critical for PHERAZINE VC’s sales?
Emerging economies in Asia and Africa remain important due to affordability and established use.


Citations:

[1] IBISWorld, “Antipsychotic Drugs Market Research,” 2022.
[2] EvaluatePharma, “Global Psychiatry Market,” 2022.
[3] FDA, “Drug Approvals and Labeling,” 2023.
[4] IQVIA, “Global Market Trends in Mental Health Medications,” 2022.
[5] WHO, “Mental Health Treatment Landscape,” 2021.

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