Get our Free Drug Patent Expiration Updates

Serving hundreds of leading biopharmaceutical companies globally:

US Department of Justice
Cerilliant
Citi
Argus Health
UBS
Fish and Richardson
Accenture
Medtronic
Healthtrust

Generated: December 10, 2018

DrugPatentWatch Database Preview

NARCAN Drug Profile

« Back to Dashboard

When do Narcan patents expire, and what generic alternatives are available?

Narcan is a drug marketed by Adapt and Bristol Myers Squibb and is included in five NDAs. There are eight patents protecting this drug and two Paragraph IV challenges.

This drug has fifteen patent family members in twelve countries.

The generic ingredient in NARCAN is naloxone hydrochloride. There are twelve drug master file entries for this compound. Twenty-one suppliers are listed for this compound. Additional details are available on the naloxone hydrochloride profile page.

Drug patent expirations by year for NARCAN
Pharmacology for NARCAN
Drug ClassOpioid Antagonist
Mechanism of ActionOpioid Antagonists
Medical Subject Heading (MeSH) Categories for NARCAN
Synonyms for NARCAN
(-)-N-allyl-14-hydroxynordihydroxymorphinan-6-one
(-)-Naloxone
(1S,5R,13R,17S)-10,17-dihydroxy-4-(prop-2-en-1-yl)-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one
(1S,5R,13R,17S)-10,17-dihydroxy-4-(prop-2-en-1-yl)-12-oxa-4-azapentacyclo[9.6.1.0;{1,13}.0;{5,17}.0;{7,18}]octadeca-7(18),8,10-trien-14-one
(1S,5R,13R,17S)-10,17-DIHYDROXY-4-(PROP-2-EN-1-YL)-12-OXA-4-AZAPENTACYCLO[9.6.1.0(1),(1)(3).0?,(1)?.0?,(1)?]OCTADECA-7(18),8,10-TRIEN-14-ONE
(4R,4aS,7aR,12bS)-3-allyl-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;hydrochloride
(4R,4aS,7aR,12bS)-4a,9-bis(oxidanyl)-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;hydrochloride
(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;hydrochloride
(5alpha)-3,14-dihydroxy-17-prop-2-en-1-yl-4,5-epoxymorphinan-6-one
(5alpha)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one
(naloxone) 4-allyl-10,17-dihydroxy-(1S,5R,13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one
(naloxone)4-allyl-10,17-dihydroxy-(1S,5R,13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one
(naloxone)4-allyl-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one
[17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydroxymorphinan-6-one
[3H]naloxone
[N-allyl-2,3-3H]naloxone
1-N-Allyl-14-hydroxynordihydromorphinone
1-N-Allyl-7,8-dihydro-14-hydroxynormorphinone
12-Allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4aH-8,9c-iminoethanophenanthro(4,5-bcd)furanone
12-Allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4aH-8,9c-iminoethanophenanthro[4,5-bcd]furan-5(6H)-one
17-allyl-3,14-dihydroxy-4,5alpha-epoxymorphinan-6-one
17-Allyl-4,5-alpha-epoxy-3,14-dihydroxymorphinan-6-one
17-Allyl-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one
3,14-dihydroxy-17-(prop-2-en-1-yl)-4,5alpha-epoxymorphinan-6-one
357-08-4 (hydrochloride)
36B82AMQ7N
4-allyl-10,17-dihydroxy-(1S,5R,13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one
4-allyl-10,17-dihydroxy-(1S,5R,13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one (naloxone)
4-allyl-10,17-dihydroxy-(1S,5R,13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one( Naloxone)
4-allyl-10,17-dihydroxy-(1S,5R,13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one(Naxolone)
4-allyl-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one
4-allyl-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one(naloxone)C2H2O4
465-65-6
465N656
4aH-8,5-bcd]furan-5(6H)-one, N-allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-
AJ-20933
AK113003
AKOS016009988
AN-45114
API0003490
BDBM50000788
BDBM54795
BIDD:GT0110
BPBio1_000136
BRD-K67511046-003-03-7
BRN 1089071
BSPBio_000122
C07252
CAS-465-65-6
CHEBI:7459
CHEMBL80
cid_5464092
D08249
D0RN5A
D0X3FX
DB01183
DBL Naloxone
DBL Naloxone (TN)
DSSTox_CID_3349
DSSTox_GSID_23349
DSSTox_RID_76986
DTXSID8023349
EINECS 207-365-7
EN 1530 base
EN 1530base
Evzio
GTPL1638
GTPL1676
HMS2090F20
HSDB 3279
KB-297992
l-N-Allyl-14-hydroxynordihydromorphinone
l-N-Allyl-7,8-dihydro-14-hydroxynormorphinone
l-Naloxone
LS-187184
LS-92141
MCULE-1335589007
MLS000069540
MLS000736771
Morphinan-6-one, 17-allyl-4,5alpha-epoxy-3,14-dihydroxy-
Morphinan-6-one, 17-allyl-4,5alpha-epoxy-3,14-dihydroxy- (8CI)
Morphinan-6-one, 17-allyl-4,5alpha-epoxy-3,14-dihydroxy-(8CI)
Morphinan-6-one, 4,5-alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)-
Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-
Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)- (9CI)
Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-(9CI)
Morphinan-6-one, 4,5alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)-
Morphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-,(5|A)-
Morphinan-6-one,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5.alpha.)-
Morphinan-6-one,5.alpha.-epoxy-3,14-dihydroxy-
Morphinan-6-one,5.alpha.-epoxy-3,14-dihydroxy-17-(2-propenyl)-
N-Allyl-4,5alpha-epoxy-3,14-dihydroxy-6-morphinanon
N-Allyl-noroxymorphone
n-Allylnoroxymorphone
Nalone
Nalone (TN)
Nalossone
Nalossone [DCIT]
Naloxona
Naloxona [INN-Spanish]
naloxone
Naloxone (INN)
Naloxone [INN:BAN]
Naloxone HCl
Naloxone Hydrobromide
naloxone hydrochloride hydrate
Naloxone Nasal Spray
Naloxone solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material
Naloxonum
Naloxonum [INN-Latin]
Narcan (TN)
Narcanti
Narcanti (TN)
Narcon
NCGC00024674-02
NCGC00024674-03
NCGC00162267-02
NCGC00274058-01
Normorphinone, N-allyl-7,8-dihydro-14-hydroxy-, (-)-
Normorphinone, N-allyl-dihydro-14-hydroxy-
NSC 70413
NSC-70413
NSC70413
O940
PDSP2_001520
PL006225
Prestwick0_000111
Prestwick1_000111
Prestwick2_000111
Prestwick3_000111
SCHEMBL34284
SMP1_000205
SMR000058766
SPBio_002061
STOCK1N-69923
Tox21_112006
Tox21_112006_1
UNII-36B82AMQ7N
UZHSEJADLWPNLE-GRGSLBFTSA-N
ZINC389747

US Patents and Regulatory Information for NARCAN

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Adapt NARCAN naloxone hydrochloride INJECTABLE;INJECTION 016636-002 Approved Prior to Jan 1, 1982 DISCN Yes No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Adapt NARCAN naloxone hydrochloride SPRAY, METERED;NASAL 208411-002 Jan 24, 2017 DISCN Yes No ➤ Sign Up ➤ Sign Up Y ➤ Sign Up
Bristol Myers Squibb NARCAN naloxone hydrochloride INJECTABLE;INJECTION 071083-001 Jul 28, 1988 DISCN No No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Adapt NARCAN naloxone hydrochloride SPRAY, METERED;NASAL 208411-001 Nov 18, 2015 RX Yes Yes ➤ Sign Up ➤ Sign Up ➤ Sign Up
Adapt NARCAN naloxone hydrochloride SPRAY, METERED;NASAL 208411-002 Jan 24, 2017 DISCN Yes No ➤ Sign Up ➤ Sign Up Y ➤ Sign Up
Adapt NARCAN naloxone hydrochloride SPRAY, METERED;NASAL 208411-001 Nov 18, 2015 RX Yes Yes ➤ Sign Up ➤ Sign Up Y ➤ Sign Up
Adapt NARCAN naloxone hydrochloride INJECTABLE;INJECTION 016636-001 Approved Prior to Jan 1, 1982 DISCN Yes No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration

This preview shows a limited data set.
Subscribe to access the full database, or try a Free Trial

Paragraph IV (Patent) Challenges for NARCAN
Drugname Dosage Strength RLD Date
➤ Subscribe Nasal Spray 2 mg/spray ➤ Subscribe ➤ Sign Up
➤ Subscribe Nasal Spray 4 mg/spray ➤ Subscribe ➤ Sign Up

Supplementary Protection Certificates for NARCAN

Supplementary Protection Certificate SPC Country SPC Expiration SPC Description
292 Luxembourg ➤ Sign Up PRODUCT NAME: COMBINAISON D OXYCODONE EN TANT QUE COMPOSANT A ET DE NALOXONE EN TANT QUE COMPOSANT B SOUS TOUTES LES FORMES PROTEGES PAR LE BREVET DE BASE
Supplementary Protection Certificate SPC Country SPC Expiration SPC Description

This preview shows a limited data set.
Subscribe to access the full database, or try a Free Trial

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Teva
Farmers Insurance
Queensland Health
Argus Health
Federal Trade Commission
Fuji
Accenture
US Army
Cipla

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.