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Last Updated: December 15, 2025

MEXATE Drug Patent Profile


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Summary for MEXATE
Drug patent expirations by year for MEXATE
Recent Clinical Trials for MEXATE

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SponsorPhase
City of Hope Medical CenterPhase 2
Children's Oncology GroupPhase 2/Phase 3
City of Hope Medical CenterPhase 1

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US Patents and Regulatory Information for MEXATE

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Bristol MEXATE methotrexate sodium INJECTABLE;INJECTION 086358-001 Approved Prior to Jan 1, 1982 DISCN Yes No ⤷  Get Started Free ⤷  Get Started Free ⤷  Get Started Free
Bristol MEXATE methotrexate sodium INJECTABLE;INJECTION 086358-004 Approved Prior to Jan 1, 1982 DISCN Yes No ⤷  Get Started Free ⤷  Get Started Free ⤷  Get Started Free
Bristol MEXATE methotrexate sodium INJECTABLE;INJECTION 086358-002 Approved Prior to Jan 1, 1982 DISCN Yes No ⤷  Get Started Free ⤷  Get Started Free ⤷  Get Started Free
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Market Dynamics and Financial Trajectory for the Pharmaceutical Drug: MEXATE

Last updated: July 29, 2025


Introduction

MEXATE, known generically as propoxur, holds a distinctive position within the pesticide and insecticide spectrum rather than as a conventional pharmaceutical drug. However, certain formulations, especially in regions with specific pest control regulatory regimes, position MEXATE as a critical agent in agricultural and vector control markets. Understanding the market dynamics and financial trajectory of MEXATE necessitates a nuanced analysis of regulatory landscapes, patent statuses, environmental concerns, and global demand for pest control solutions.


Regulatory Environment and Market Impact

The primary factor influencing MEXATE’s market trajectory concerns shifting regulatory paradigms, particularly those orchestrated by agencies like the U.S. EPA, European Chemicals Agency, and various national pesticide committees. MEXATE’s chemical profile, as a carbamate insecticide, raises concerns over human health and environmental safety, leading to regulatory restrictions or bans in several jurisdictions.

Regulatory Restrictions:
In 2005, the EPA announced the cancellation of MEXATE registrations due to risks to aquatic non-target species and potential endocrine disruption in humans (EPA, 2005). Similar restrictions in the European Union followed the EU’s pesticide framework, with MEXATE effectively phased out [1]. These measures significantly curtailed new growth opportunities, especially in developed markets, impacting sales revenues and investment inflows.

Emergence of Alternative Pesticides:
Intensifying environmental concerns prompted a shift toward organophosphates and biopesticides, driven by regulatory favorability and consumer demand for organic and residue-free produce. This transition further limits MEXATE’s usage, emphasizing the importance of regulatory agility for market sustainability.


Market Demand and Geographic Segmentation

Despite restrictions, MEXATE retains relevance in certain emerging markets and niche applications.

Developing Countries:
In regions with less stringent regulations, such as parts of Africa, Southeast Asia, and Latin America, MEXATE continues to be vital for controlling mosquitoes, crop pests, and vectors of disease. These markets are less exposed to regulatory bans but face growing pressure from international health and safety standards, potentially jeopardizing future usage.

Vector Control in Public Health:
MEXATE’s efficacy against disease carriers like mosquitoes offers potential in malaria, dengue, and Zika virus control. However, alternative vector control strategies, including novel insecticides and biological agents, threaten MEXATE’s market share in public health.

Agricultural Pest Control:
In agriculture, demand hinges on the crop type, pest pressure, and local pesticide legislation. Its use is concentrated where benefits outweigh environmental concerns, keeping MEXATE relevant but under ongoing scrutiny.


Competitive Landscape and Innovation

The pesticide industry is highly competitive, with key players including Bayer CropScience, FMC Corporation, and Syngenta. These firms invest heavily in developing or licensing safer, more sustainable solutions, gradually replacing older chemicals like MEXATE.

Innovation and Alternatives:
Biopesticides and genetically modified crops offer safer, targeted pest control, reducing reliance on traditional chemicals. The adoption rate for these alternatives varies regionallybut accelerates, threatening MEXATE’s longevity.

Patent and Intellectual Property:
MEXATE originally benefitted from patent protections, but most patents have expired, opening the field to generics. This proliferation intensifies price competition and constrains profit margins.


Financial Trajectory and Investment Outlook

The financial prospects for MEXATE are mixed, reflecting evolving regulations, market demand, and competitive pressures.

Historical Revenue Trends:
Prior to regulatory restrictions, MEXATE experienced steady growth driven by emerging markets. Post-2005, revenues declined sharply in developed nations, with some sustained in less regulated regions.

Current Market Valuation:
As a pesticide, MEXATE’s market valuation is now niche and fragmented. Its financial outlook emphasizes stable revenues in specific regions but limited long-term growth prospects without significant regulatory leniency or product reformulation.

Future Growth Drivers:
Potential growth hinges on innovative formulations, such as microencapsulation or bio-based derivatives, which could mitigate environmental risks and align with global sustainability targets. Investment in such R&D could rejuvenate MEXATE’s market relevance and financial performance.

Risk Considerations:
Regulatory tightening, environmental activism, and market shifts toward organic farming pose substantial risks. Additionally, re-emergence of competitor products or legal liabilities from past exposures could impair financial forecasts.


Strategic Implications for Stakeholders

For industry stakeholders, including investors, manufacturers, and regional distributors, strategic focus areas include:

  • Navigating regulatory landscapes through reformulation or restructuring.
  • Diversifying portfolios toward sustainable pest control solutions.
  • Engaging in R&D for environmentally friendly derivatives.
  • Expanding into markets with lenient regulatory environments.
  • Monitoring public health trends to align product development with emerging demands.

Conclusion

The market dynamics for MEXATE are characterized by decline in developed economies, persistent demand in specific emerging markets, and a clear shift toward safer, sustainable pest control alternatives. Its financial trajectory appears constrained but potentially salvageable through innovation and strategic market positioning. Stakeholders must remain vigilant to regulatory trends and technological advances shaping the future of pesticide use.


Key Takeaways

  • Regulatory restrictions have significantly diminished MEXATE’s global market scope, especially in Europe and North America.
  • Emerging markets still rely on MEXATE, but growth is limited by environmental concerns and potential future bans.
  • Innovation efforts focused on developing bio-based or encapsulated formulations could prolong MEXATE’s relevance.
  • Competitive pressures from safer alternatives lead to declining profit margins and decreased investment appeal.
  • Strategic diversification and adaptation are vital for maintaining financial sustainability within the evolving pesticide industry landscape.

FAQs

1. What are the primary regulatory challenges facing MEXATE today?
Regulators worldwide have raised concerns regarding MEXATE’s environmental persistence and toxicity, leading to bans and restrictions, notably in the EU and North America. These challenges limit market access and usage approvals.

2. Can reformulation extend MEXATE’s market viability?
Yes, innovations such as microencapsulation or bio-based derivatives may reduce environmental impact, which could facilitate regulatory approval and extend its utility.

3. Which markets represent the best growth opportunities for MEXATE?
Developing nations with less restrictive pesticide regimes continue to use MEXATE in agriculture and vector control, offering some growth potential but with uncertainty due to future regulatory evolution.

4. How does environmental activism impact MEXATE’s prospects?
Environmental groups advocate for banning or restricting hazardous pesticides. Their influence can accelerate regulation, decrease demand, and diminish MEXATE’s market viability.

5. What alternatives are replacing MEXATE in pest control?
Biopesticides, genetically modified crops, and integrated pest management strategies are increasingly replacing older chemicals like MEXATE, driven by safety, sustainability, and regulatory incentives.


References

[1] U.S. Environmental Protection Agency. (2005). Cancellation of Certain Pesticides.

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