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Last Updated: November 20, 2019

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LOCOID Drug Profile

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When do Locoid patents expire, and what generic alternatives are available?

Locoid is a drug marketed by Bausch, Yamanouchi, and Precision Dermat. and is included in eight NDAs. There are two patents protecting this drug and two Paragraph IV challenges.

The generic ingredient in LOCOID is hydrocortisone butyrate. There are sixty-seven drug master file entries for this compound. Nine suppliers are listed for this compound. Additional details are available on the hydrocortisone butyrate profile page.

Drug patent expirations by year for LOCOID
Drug Prices for LOCOID

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Drug Sales Revenue Trends for LOCOID

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Recent Clinical Trials for LOCOID

Identify potential brand extensions & 505(b)(2) entrants

SponsorPhase
LEO PharmaPhase 1
Icahn School of Medicine at Mount SinaiN/A
GlaxoSmithKlinePhase 4

See all LOCOID clinical trials

Pharmacology for LOCOID
Synonyms for LOCOID
(11beta)-11,21-Dihydroxy-17-(1-oxobutoxy)pregn-4-ene-3,20-dione
(1S,10S,11S,15S,17S,2R,14R)-17-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyl-5-ox otetracyclo[8.7.0.0<2,7>.0<11,15>]heptadec-6-en-14-yl butanoate
[(8S,9S,10R,11S,13S,14S,17R)-10,13-dimethyl-11-oxidanyl-17-(2-oxidanylethanoyl)-3-oxidanylidene-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] butanoate
[(8S,9S,10R,11S,13S,14S,17R)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] butanoate
05RMF7YPWN
11-beta,17-alpha,21-Trihydroxy-4-pregnene-3,20-dione 17-alpha-butyrate
11|A,17,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate
11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate
11beta,21-dihydroxy-17alpha-butyryloxy-4-pregnene-3,20-dione
11beta,21-dihydroxy-3,20-dioxopregn-4-en-17-yl butanoate
135467-84-4
13609-67-1
17-O-butyrylcortisol
609H671
A807026
AC-492
AC1L1AHF
AC1Q6OBN
AJ-47560
AKOS015895443
Alfason
AN-15773
API0005043
AX8134121
BC214764
BCP11925
Bucort
butanoic acid [(8S,9S,10R,11S,13S,14S,17R)-11-hydroxy-17-(2-hydroxy-1-oxoethyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] ester
Butyric acid hydrocortisone
CAS-13609-67-1
CHEBI:31674
CHEMBL1683
Cortisol 17-butyrate
CORTISOL, 17-BUTYRATE
CS-4474
CTK0H7965
D01619
DSSTox_CID_25896
DSSTox_GSID_45896
DSSTox_RID_81208
DTXSID4045896
EINECS 237-093-4
Epitope ID:119710
H-17-B
H.17B
HB(sub 17)
HMS2231B16
HY-B0983
Hycortate
Hydrocortisone 17-butyrate
hydrocortisone butyrate
Hydrocortisone Butyrate (Hydrocortisone 17-Butyrate)
Hydrocortisone butyrate (JP17/USP)
Hydrocortisone butyrate [USAN:BAN:JAN]
Hydrocortisone butyrate [USAN:USP:BAN:JAN]
Hydrocortisone butyrate, United States Pharmacopeia (USP) Reference Standard
Hydrocortisone-17-butyrate
Hydrocortisone-17alpha-butyrate
KB-277960
Lacoid
Lacoidon
Laticort
locoid (TN)
LS-54996
MFCD00083364
MLS000028716
MLS001076086
MLS002207122
MolPort-003-941-574
NCGC00095037-01
NCGC00274077-01
Opera_ID_188
Pregn-4-ene-3,20-dione, 11,21-dihydroxy-17-(1-oxobutoxy)-, (11-beta)-
Pregn-4-ene-3,20-dione, 11,21-dihydroxy-17-(1-oxobutoxy)-, (11beta)-
SCHEMBL4695
SMR000058859
ST075194
Tox21_111397
Tox21_111397_1
UNII-05RMF7YPWN
W-108252
ZINC3977794
Paragraph IV (Patent) Challenges for LOCOID
Tradename Dosage Ingredient NDA Submissiondate
LOCOID LOTION;TOPICAL hydrocortisone butyrate 022076 2016-08-31

US Patents and Regulatory Information for LOCOID

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Bausch LOCOID hydrocortisone butyrate CREAM;TOPICAL 018514-001 Mar 31, 1982 AB1 RX Yes Yes   Start Trial   Start Trial   Start Trial
Bausch LOCOID hydrocortisone butyrate SOLUTION;TOPICAL 019116-001 Feb 25, 1987 AT RX Yes Yes   Start Trial   Start Trial   Start Trial
Bausch LOCOID hydrocortisone butyrate LOTION;TOPICAL 022076-001 May 18, 2007 AB RX Yes Yes   Start Trial   Start Trial Y   Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Premature patent expiration for: LOCOID

Expiration due to failure to pay maintenance fee

Patent Number Tradename Expiration Date
  Start Trial LOCOID   Start Trial

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Serving leading biopharmaceutical companies globally:

Mallinckrodt
McKinsey
Boehringer Ingelheim
Colorcon
Express Scripts
Medtronic

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