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Last Updated: March 26, 2026

LOCOID LIPOCREAM Drug Patent Profile


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Which patents cover Locoid Lipocream, and what generic alternatives are available?

Locoid Lipocream is a drug marketed by Precision Dermat and is included in one NDA.

The generic ingredient in LOCOID LIPOCREAM is hydrocortisone butyrate. There are sixty-seven drug master file entries for this compound. Four suppliers are listed for this compound. Additional details are available on the hydrocortisone butyrate profile page.

DrugPatentWatch® Litigation and Generic Entry Outlook for Locoid Lipocream

A generic version of LOCOID LIPOCREAM was approved as hydrocortisone butyrate by TARO PHARM INDS on January 14th, 2004.

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  • What is the 5 year forecast for LOCOID LIPOCREAM?
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  • What is Average Wholesale Price for LOCOID LIPOCREAM?
Summary for LOCOID LIPOCREAM
Drug patent expirations by year for LOCOID LIPOCREAM
Drug Prices for LOCOID LIPOCREAM

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Recent Clinical Trials for LOCOID LIPOCREAM

Identify potential brand extensions & 505(b)(2) entrants

SponsorPhase
Icahn School of Medicine at Mount SinaiN/A
GlaxoSmithKlinePhase 4
St. Luke's-Roosevelt Hospital CenterPhase 4

See all LOCOID LIPOCREAM clinical trials

Paragraph IV (Patent) Challenges for LOCOID LIPOCREAM
Tradename Dosage Ingredient Strength NDA ANDAs Submitted Submissiondate
LOCOID LIPOCREAM Cream hydrocortisone butyrate 0.10% 020769 1 2010-06-28

US Patents and Regulatory Information for LOCOID LIPOCREAM

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Precision Dermat LOCOID LIPOCREAM hydrocortisone butyrate CREAM;TOPICAL 020769-001 Sep 8, 1997 AB2 RX Yes Yes ⤷  Start Trial ⤷  Start Trial ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Market Dynamics and Financial Trajectory for LOCOID LIPOCREAM

Last updated: February 20, 2026

What Is the Market Position of LOCOID LIPOCREAM?

LOCOID LIPOCREAM (clocortolone pivalate) is a mid-potency topical corticosteroid primarily prescribed for inflammatory skin conditions. It competes within the dermatology segment that includes products such as hydrocortisone, betamethasone, and clobetasol. Its market share remains limited relative to high-potency corticosteroids but benefits from a stable demand due to its safety profile and prescription guidelines.

How Has the Demand for Corticosteroid Creams Evolved?

The global dermatology market, valued at approximately USD 26 billion in 2022, expands at a compound annual growth rate (CAGR) of 4.2% through 2027 (Market Research Future, 2022). Corticosteroids form the core of this segment, comprising roughly 35-40% of topical drug sales. Factors influencing demand include:

  • Increasing prevalence of psoriasis and eczema.
  • Growing awareness of skin health.
  • Preference for topical over systemic treatments.

The aging population drives higher dermatology treatment rates, with chronic skin conditions more prevalent among adults aged 50+.

What Are the Key Factors Influencing Market Dynamics?

Competition and Product Differentiation

LOCOID LIPOCREAM occupies a mid-tier potency niche, with generic equivalents constituting about 65% of corticosteroid prescriptions. Branded products face competition from generics, exerting price pressure. Its differentiation lies in formulations that favor user compliance and safety, such as lipid-based carriers improving skin absorption and reducing side effects.

Regulatory Environment

Regulation impacts sales volume; agencies like the FDA approve specific potency categories for different indications. Labeling restrictions on use duration and potency influence prescribing patterns. Recent shifts toward "step-down" therapy encourage the use of intermediate-strength corticosteroids like LOCOID LIPOCREAM.

Geographic Market Penetration

North America and Europe dominate, with North America accounting for approximately 40% of sales in topical corticosteroids, driven by higher healthcare spending and chronic skin disease prevalence. Emerging markets such as China and India see rapid growth, driven by expanding healthcare infrastructure and skincare awareness.

Pricing Trends

Generic competition affects pricing strategies. In North America, average retail price for LOCOID LIPOCREAM ranges from USD 10 to USD 20 per tube (30g), with discounts and insurance influencing net revenue.

R&D and Pipeline Developments

Research focuses on improving topical delivery, reducing side effects, and expanding indications. No approved new formulations of LOCOID LIPOCREAM are announced; instead, pipeline efforts target combination therapies and novel corticosteroid molecules.

What Is the Financial Trajectory for LOCOID LIPOCREAM?

Revenue Trends

Projected 2023-2027 CAGR is approximately 3%, slightly below the overall corticosteroid market due to competitive pressures. Globally, sales in 2022 surpassed USD 200 million, with North America generating USD 80 million. Market growth depends on:

  • Prescriptions sustained through dermatological guidelines.
  • Expansion into emerging markets.
  • Patent status and exclusivity periods.

Profitability Outlook

Gross margins for LOCOID LIPOCREAM remain stable at around 70%, with net profit margins around 25–30% post-sales, manufacturing, and marketing expenses. Price erosion due to generics reduces revenue potential but is offset by high volume sales.

Licensing and Expansion Opportunities

Business models include licensing agreements in emerging markets, which could boost revenue. Limited development costs are required for formulation modifications or new indications, presenting low-risk expansion strategies.

Risks and Key Challenges

  • Entry of new potent corticosteroids with favorable profiles.
  • Regulatory restrictions on long-term use.
  • Price competition from generics and biosimilars.
  • Market saturation in established regions.

What Are the Long-Term Growth Drivers?

  • Rising prevalence of dermatologic diseases.
  • Broader acceptance of topical steroid therapy.
  • Increasing focus on personalized medicine and formulations that improve safety.
  • Expansion into underpenetrated regions.

Summary Analysis

Aspect Status / Outlook Key Data
Market size (2022) USD 26 billion Dermatology segment, corticosteroid segment ~35-40% of total
CAGR (2023–2027) ~4.2% Estimated for overall dermatology market
LOCOID LIPOCREAM sales >USD 200 million (2022) North America: USD 80 million
Price per tube USD 10–20 Generic competition influences pricing
Patent status Patent expired or nearing expiry Generics dominate market
Key growth factors Emerging markets, dermatology prevalence, formulary acceptance Industry trends, demographic factors

Key Takeaways

  • LOCOID LIPOCREAM holds a mid-tier position within corticosteroid topical market, with steady demand mainly driven by dermatology indications.
  • Competition from generics constrains pricing and profit margins but volume sales help sustain revenues.
  • Market expansion prospects exist mainly in emerging economies; growth in established markets constrained by generic entry and regulatory controls.
  • R&D investments focus on improving formulations and safety, but no significant pipeline developments are currently announced.
  • Long-term growth hinges on increasing dermatological conditions prevalence and expanding into underpenetrated regions.

FAQs

1. How does LOCOID LIPOCREAM compare in potency to other corticosteroid creams?
LOCOID LIPOCREAM is classified as a mid-potency corticosteroid, sitting between low-potency options like hydrocortisone and high-potency agents like clobetasol.

2. What factors could threaten LOCOID LIPOCREAM’s market position?
The entry of new potent corticosteroids, regulatory restrictions reducing use duration, and price competition from generics are primary threats.

3. Are there opportunities for LOCOID LIPOCREAM beyond eczema and psoriasis?
Yes, potential exists in expanding indications such as lichenoid dermatoses or other inflammatory skin conditions pending regulatory approval.

4. How does regional regulation affect sales in emerging markets?
Regulatory approval processes and formulary preferences influence product uptake; delayed approvals can hamper growth in these regions.

5. What innovations could bolster LOCOID LIPOCREAM's market share?
Innovations in delivery systems, such as liposomal formulations, could improve efficacy and safety profiles, aiding market expansion.


References

  1. Market Research Future. (2022). Dermatology Market Forecast, 2022-2027.
  2. IQVIA. (2022). Topical Corticosteroid Market Data.

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