JAKAFI Drug Patent Profile
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Which patents cover Jakafi, and what generic alternatives are available?
Jakafi is a drug marketed by Incyte Corp and is included in one NDA. There are eight patents protecting this drug and one Paragraph IV challenge.
This drug has two hundred and thirty-three patent family members in forty-six countries.
The generic ingredient in JAKAFI is ruxolitinib phosphate. There are two drug master file entries for this compound. One supplier is listed for this compound. Additional details are available on the ruxolitinib phosphate profile page.
DrugPatentWatch® Generic Entry Outlook for Jakafi
Jakafi was eligible for patent challenges on November 16, 2015.
By analyzing the patents and regulatory protections it appears that the earliest date
for generic entry will be December 12, 2028. This may change due to patent challenges or generic licensing.
There is one Paragraph IV patent challenge for this drug. This may lead to patent invalidation or a license for generic production.
Indicators of Generic Entry
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Summary for JAKAFI
| International Patents: | 233 |
| US Patents: | 8 |
| Applicants: | 1 |
| NDAs: | 1 |
| Finished Product Suppliers / Packagers: | 1 |
| Raw Ingredient (Bulk) Api Vendors: | 65 |
| Clinical Trials: | 80 |
| Patent Applications: | 382 |
| Drug Prices: | Drug price information for JAKAFI |
| Patent Litigation and PTAB cases: | See patent lawsuits and PTAB cases for JAKAFI |
| What excipients (inactive ingredients) are in JAKAFI? | JAKAFI excipients list |
| DailyMed Link: | JAKAFI at DailyMed |
DrugPatentWatch® Estimated Loss of Exclusivity (LOE) Date for JAKAFI
*The generic entry opportunity date is the latter of the last compound-claiming patent and the last regulatory exclusivity protection. Many factors can influence early or later generic entry. This date is provided as a rough estimate of generic entry potential and should not be used as an independent source.
Recent Clinical Trials for JAKAFI
Identify potential brand extensions & 505(b)(2) entrants
| Sponsor | Phase |
|---|---|
| City of Hope Medical Center | Phase 2 |
| Washington University School of Medicine | Phase 1 |
| Karyopharm Therapeutics Inc | Phase 2 |
Pharmacology for JAKAFI
| Drug Class | Janus Kinase Inhibitor Kinase Inhibitor |
| Mechanism of Action | Janus Kinase Inhibitors |
Paragraph IV (Patent) Challenges for JAKAFI
| Tradename | Dosage | Ingredient | Strength | NDA | ANDAs Submitted | Submissiondate |
|---|---|---|---|---|---|---|
| JAKAFI | Tablets | ruxolitinib phosphate | 5 mg, 10 mg, 15 mg, 20 mg, and 25 mg | 202192 | 1 | 2015-12-17 |
US Patents and Regulatory Information for JAKAFI
JAKAFI is protected by eight US patents and eight FDA Regulatory Exclusivities.
Based on analysis by DrugPatentWatch, the earliest date for a generic version of JAKAFI is ⤷ Sign Up.
This potential generic entry date is based on patent ⤷ Sign Up.
Generics may enter earlier, or later, based on new patent filings, patent extensions, patent invalidation, early generic licensing, generic entry preferences, and other factors.
Patents protecting JAKAFI
Salts of the janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentyl- propanenitrile
Patent Number: ⤷ Sign Up
Patent Expiration: ⤷ Sign Up
Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
Patent Number: ⤷ Sign Up
Patent Expiration: ⤷ Sign Up
Pyrazolyl substituted pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
Patent Number: ⤷ Sign Up
Patent Expiration: ⤷ Sign Up
Salts of the Janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentyl- propanenitrile
Patent Number: ⤷ Sign Up
Patent Expiration: ⤷ Sign Up
Salts of the janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-d] pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
Patent Number: ⤷ Sign Up
Patent Expiration: ⤷ Sign Up
Salts of the Janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentyl- propanenitrile
Patent Number: ⤷ Sign Up
Patent Expiration: ⤷ Sign Up
Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as Janus kinase inhibitors
Patent Number: ⤷ Sign Up
Patent Expiration: ⤷ Sign Up
Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as janus kinase inhibitors
Patent Number: ⤷ Sign Up
Patent Expiration: ⤷ Sign Up
FDA Regulatory Exclusivity protecting JAKAFI
TREATMENT OF STEROID-REFRACTORY ACUTE GRAFT-VERSUS-HOST DISEASE (GVHD) IN ADULT AND PEDIATRIC PATIENTS 12 YEARS AND OLDER
Exclusivity Expiration: ⤷ Sign Up
ADDITION OF THE INDICATION OF TREATMENT OF CHRONIC GRAFT-VERSUS-HOST DISEASE (CGVHD) AFTER FAILURE OF ONE OR TWO LINES OF SYSTEMIC THERAPY IN ADULT AND PEDIATRIC PATIENTS 12 YEARS AND OLDER
Exclusivity Expiration: ⤷ Sign Up
REVISIONS TO SECTION 8.4 OF THE LABELING TO INCLUDE THE RESULTS OF STUDY INCB 18424-269
Exclusivity Expiration: ⤷ Sign Up
TREATMENT OF CHRONIC GRAFT-VERSUS-HOST DISEASE (CGVHD) AFTER FAILURE OF ONE OR TWO LINES OF SYSTEMIC THERAPY IN ADULT AND PEDIATRIC PATIENTS 12 YEARS AND OLDER
Exclusivity Expiration: ⤷ Sign Up
PEDIATRIC EXCLUSIVITY
Exclusivity Expiration: ⤷ Sign Up
PEDIATRIC EXCLUSIVITY
Exclusivity Expiration: ⤷ Sign Up
PEDIATRIC EXCLUSIVITY
Exclusivity Expiration: ⤷ Sign Up
PEDIATRIC EXCLUSIVITY
Exclusivity Expiration: ⤷ Sign Up
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Exclusivity Expiration |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Incyte Corp | JAKAFI | ruxolitinib phosphate | TABLET;ORAL | 202192-005 | Nov 16, 2011 | RX | Yes | Yes | ⤷ Sign Up | ⤷ Sign Up | ⤷ Sign Up | ||||
| Incyte Corp | JAKAFI | ruxolitinib phosphate | TABLET;ORAL | 202192-003 | Nov 16, 2011 | RX | Yes | No | ⤷ Sign Up | ⤷ Sign Up | ⤷ Sign Up | ||||
| Incyte Corp | JAKAFI | ruxolitinib phosphate | TABLET;ORAL | 202192-002 | Nov 16, 2011 | RX | Yes | No | ⤷ Sign Up | ⤷ Sign Up | ⤷ Sign Up | ||||
| Incyte Corp | JAKAFI | ruxolitinib phosphate | TABLET;ORAL | 202192-004 | Nov 16, 2011 | RX | Yes | No | ⤷ Sign Up | ⤷ Sign Up | Y | ⤷ Sign Up | |||
| >Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Exclusivity Expiration |
International Patents for JAKAFI
When does loss-of-exclusivity occur for JAKAFI?
Based on analysis by DrugPatentWatch, the following patents block generic entry in the countries listed below:
Australia
Patent: 08266183
Patent: Salts of the Janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
Estimated Expiration: ⤷ Sign Up
Brazil
Patent: 0814254
Patent: SAIS DO INIBIDOR DE JANUS QUINASE(R)-3(-4(7H-PIRROLO[2,3-D]PIRIMIDIN-4-IL)-1H-PIRAZ OL-1-IL)-3-CICLOPENTILPROPANONITRILA
Estimated Expiration: ⤷ Sign Up
Canada
Patent: 89663
Patent: SELS DE L'INHIBITEUR (7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZ OL-1-YL)-3-CYCLOPENTYLPROPANENITRILE DE LA JANUS KINASE (SALTS OF THE JANUS KINASE INHIBITOR (7H-PYRROLO[2,3-D]PYRIMIDIN -4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE)
Estimated Expiration: ⤷ Sign Up
China
Patent: 1932582
Patent: Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
Estimated Expiration: ⤷ Sign Up
Patent: 3524509
Patent: Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
Estimated Expiration: ⤷ Sign Up
Colombia
Patent: 51256
Patent: SALES DEL INHIBIDOR DE JANUS CINASA (R)-3-(4-(7H-PIRROLO[2,3-D]PIRIMIDIN-4IL)1H-PIRAZOL-1-IL)-3-CICLOPENTILPROPANITRILO
Estimated Expiration: ⤷ Sign Up
Costa Rica
Patent: 151
Patent: SALES DEL INHIBIDOR DE JANUS CINASA (R)-3-(4-(7H-PIRROLO[2,3-CICLOPENTILPROPANITRILO
Estimated Expiration: ⤷ Sign Up
Croatia
Patent: 0140541
Estimated Expiration: ⤷ Sign Up
Patent: 0160717
Estimated Expiration: ⤷ Sign Up
Patent: 0190385
Estimated Expiration: ⤷ Sign Up
Cuba
Patent: 933
Patent: SALES DEL INHIBIDOR DE JANUS CINASA (R)-3-(4-(7H-PIRROLO[2,3-D]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL)-3-CICLOPENTILPROPANITRILO
Estimated Expiration: ⤷ Sign Up
Patent: 179
Patent: SALES DE ÁCIDO MALEICO Y DE ÁCIDO SULFÚRICO DE (R)-3-(4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL)-3-CICLOPENTILPROPANITRILO
Estimated Expiration: ⤷ Sign Up
Patent: 090213
Patent: SALES DEL INHIBIDOR DE JANUS CINASA (R)-3-(4-(7H-PIRROLO[2,3-D]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL)-3-CICLOPENTILPROPANITRILO
Estimated Expiration: ⤷ Sign Up
Patent: 120155
Patent: SALES DE ÁCIDO MALEICO Y DE ÁCIDO SULFÚRICO DE (R)-3-(4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL)-3-CICLOPENTILPROPANITRILO
Estimated Expiration: ⤷ Sign Up
Cyprus
Patent: 15145
Estimated Expiration: ⤷ Sign Up
Patent: 17693
Estimated Expiration: ⤷ Sign Up
Patent: 21338
Estimated Expiration: ⤷ Sign Up
Denmark
Patent: 73752
Estimated Expiration: ⤷ Sign Up
Patent: 40731
Estimated Expiration: ⤷ Sign Up
Patent: 70090
Estimated Expiration: ⤷ Sign Up
Dominican Republic
Patent: 009000280
Patent: SALES DEL INHIBIDOR DE JANUS CINASA (R)-3-(4-(7H-PIRROLO[2,3-D]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL)-3-CICLOPENTILPROPANITRILO
Estimated Expiration: ⤷ Sign Up
Ecuador
Patent: 099802
Patent: SALES DEL INHIBIDOR DE JANUS CINASA (R)-3-(4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL)-3- CICLOPENTILPROPANITRILO
Estimated Expiration: ⤷ Sign Up
Eurasian Patent Organization
Patent: 9784
Patent: СОЛИ ИНГИБИТОРА ЯНУС-КИНАЗЫ (R)-3-(4-(7H-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)-1H-ПИРАЗОЛ-1-ИЛ)-3-ЦИКЛОПЕНТИЛПРОПАННИТРИЛА (SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE)
Estimated Expiration: ⤷ Sign Up
Patent: 1070013
Patent: СОЛИ ИНГИБИТОРА ЯНУС-КИНАЗЫ (R)-3-(4-(7H-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)-1H-ПИРАЗОЛ-1-ИЛ)-3-ЦИКЛОПЕНТИЛПРОПАННИТРИЛА
Estimated Expiration: ⤷ Sign Up
European Patent Office
Patent: 73752
Patent: SELS DE L'INHIBITEUR (R)-3-(4-(7H-PYRROLO(2,3-D)PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE DE LA JANUS KINASE (SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO(2,3-D)PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE)
Estimated Expiration: ⤷ Sign Up
Patent: 40731
Patent: Sels cristallines de l'inhibiteur de janus kinase (r)-3-(4- (7h-pyrrolo [2,3-d] pyrimidin-4-yl)-1h-pyrazol-1-yl) -3-cyclopentylpropanenitrile (CRYSTALLINE SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE)
Estimated Expiration: ⤷ Sign Up
Patent: 70090
Patent: UTILISATION DES SELS DE L'INHIBITEUR DE JANUS KINASE (R)-3-(4- (7H-PYRROLO [2,3-D] PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL) -3-CYCLOPENTYLPROPANENITRILE (USE OF SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H- PYRAZOL-1-YL)-3- CYCLOPENTYLPROPANENITRILE)
Estimated Expiration: ⤷ Sign Up
Patent: 95369
Patent: UTILISATION DES SELS DE L'INHIBITEUR DE JANUS KINASE (R)-3-(4-(7H-PYRROLO [2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE (USE OF SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H- PYRAZOL-1-YL)-3- CYCLOPENTYLPROPANENITRILE)
Estimated Expiration: ⤷ Sign Up
Patent: 11883
Patent: SELS DE L'INHIBITEUR DE JANUS KINASE (R)-3-(4-(7H-PYRROLO[2,3-D -1H-]PYRIMIDINE-4-YL) -1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE (SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H- PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE)
Estimated Expiration: ⤷ Sign Up
Georgia, Republic of
Patent: 0125533
Patent: SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYL PROPANENITRILE
Estimated Expiration: ⤷ Sign Up
Guatemala
Patent: 0900314
Patent: SALES DEL INHIBIDOR DE JANUS CINASA (R)-3-(4-(7H-PIRROLO [2,3-D] PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL)-3-CICLOPENTILPROPANITRILO
Estimated Expiration: ⤷ Sign Up
Hong Kong
Patent: 43161
Patent: 激酶抑制劑 -吡咯 嘧啶- -基 -吡唑- -基 -環戊基丙腈的鹽 (SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4- YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE JANUS (R)-3-(4-(7H-[23-D]-4-)-1H--1-)-3-)
Estimated Expiration: ⤷ Sign Up
Patent: 98652
Patent: 激酶抑制劑 -吡咯 嘧啶- -基 -吡唑- -基 -環戊基丙腈的結晶鹽 (CRYSTALLINE SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3- D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE JANUS (R)-3-(4-(7H-[23-D]-4-)-1H--1-)-3-)
Estimated Expiration: ⤷ Sign Up
Hungary
Patent: 29236
Estimated Expiration: ⤷ Sign Up
Patent: 43732
Estimated Expiration: ⤷ Sign Up
Israel
Patent: 2524
Patent: מלחים של מדכא ג'אנוס קינאס (r)-3- (4-(7h-פירולו[d-3, 2]פירימידין -4-איל)-h 1-פיראזול-1-איל)-3-ציקלופנטילפרופאנאניטריל (Salts of the janus kinase inhibitor (r)-3-(4-(7 h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile)
Estimated Expiration: ⤷ Sign Up
Patent: 4276
Patent: מלחים של מדכא ג'אנוס קינאס (r)- 3- (4-(h7-פירולו[d - 2,3]פירימידין-4-איל)-1h-פיראזול-1l-איל)-3-ציקלופנטילפרופאנאניטריל (Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-)
Estimated Expiration: ⤷ Sign Up
Patent: 0401
Patent: מלחים של מדכא ג'אנוס קינאס (r)- 3- (4-(h7-פירולו[d - 2,3]פירימידין-4-איל)-1h-פיראזול-1l-איל)-3-ציקלופנטילפרופאנאניטריל (Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile)
Estimated Expiration: ⤷ Sign Up
Patent: 7708
Patent: מלחים של מדכא ג'אנוס קינאס (r)- 3- (4-(h7-פירולו[d - 2,3]פירימידין-4-איל)-1h-פיראזול-1l-איל)-3-ציקלופנטילפרופאנאניטריל (Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile)
Estimated Expiration: ⤷ Sign Up
Japan
Patent: 75653
Estimated Expiration: ⤷ Sign Up
Patent: 10529209
Estimated Expiration: ⤷ Sign Up
Lithuania
Patent: 70090
Estimated Expiration: ⤷ Sign Up
Malaysia
Patent: 4969
Patent: SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE
Estimated Expiration: ⤷ Sign Up
Mexico
Patent: 2814
Patent: SALES DE INHIBIDOR DE JANUS CINASA (R)-3-(4-7H-PIRROLO[2,3-D]PIRIM IDIN-4-IL)-1H-PIRAZOL-1-IL)-3-CICLOPENTILPROPANITRILO. (SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-D]PY RIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE.)
Estimated Expiration: ⤷ Sign Up
Patent: 09013402
Patent: SALES DE INHIBIDOR DE JANUS CINASA (R)-3-(4-(7H-PIRROLO[2,3-D]PIRI MIDIN-4-IL)-1H-PIRAZOL-1-IL)-3-CICLOPENTILPROPANITRILO. (SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-D]PY RIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE.)
Estimated Expiration: ⤷ Sign Up
Montenegro
Patent: 960
Patent: SOLI INHIBITORA JANUS KINAZE, (R)-3-(4-(7H-PIROL[2,3-D]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL)-3-CIKLOPENTILPROPANNITRILA (SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE)
Estimated Expiration: ⤷ Sign Up
Morocco
Patent: 517
Patent: املاح المثبط (r)-3-(4-(7h-البيرولو(3،2- d)بيرميدين-4- yl)- 1h-بيرازول-1- yl)-3_ سيكلوبينتيلبروباننيتريل من يانوس الكيناز.
Estimated Expiration: ⤷ Sign Up
New Zealand
Patent: 1803
Patent: SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE
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Nicaragua
Patent: 0900216
Patent: SALES DE INHIBIDOR DE JANUS CINASA ( R ) - ( 3 ) - ( 4 - ( 7H - PIRROLO [ 2,3-D ] PIRIMIDIN - 4 - IL ) - 1H - PIRAZOL - 1 - IL) - 3 - CICLOPENTILPROPANENITRILO.
Estimated Expiration: ⤷ Sign Up
Norway
Patent: 19025
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Poland
Patent: 73752
Estimated Expiration: ⤷ Sign Up
Patent: 40731
Estimated Expiration: ⤷ Sign Up
Patent: 70090
Estimated Expiration: ⤷ Sign Up
Portugal
Patent: 73752
Estimated Expiration: ⤷ Sign Up
Patent: 70090
Estimated Expiration: ⤷ Sign Up
San Marino
Patent: 201000002
Patent: Sali dell'inibitore di chinasi janus (r)-3-(4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazoli-1-il)-3-ciclopentilpropanonitrile
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Patent: 01000002
Patent: Sali dell'inibitore di chinasi janus (R)-3-(4-(7H-pirrolo[2,3-D]pirimidin-4-IL)-1H-pirazoli-1-IL)-3-ciclopentilpropanonitrile
Estimated Expiration: ⤷ Sign Up
Serbia
Patent: 245
Patent: SOLI INHIBITORA JANUS KINAZE (R)-3-(4-(7H-PIROLO(2,3-D) PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL)-3-CIKLOPENTILPROPAN-NITRILA (SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO(2,3-D)PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE)
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Patent: 878
Patent: KRISTALNE SOLI INHIBITORA JANUS KINAZE (R)-3-(4-(7H-PIROLO[2,3-D]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL)-3-CIKLOPENTILPROPIONITRIL (CRYSTALLINE SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE)
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Patent: 449
Patent: UPOTREBA SOLI INHIBITORA JANUS KINAZE (R)-3-(4-(7H-PIROLO[2,3-D]PIRIMIDIN-4-IL)-1H- PIRAZOL-1-IL)-3-CIKLOPENTILPROPIONITRILA (USE OF SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H- PYRAZOL-1-YL)-3- CYCLOPENTYLPROPANENITRILE)
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Singapore
Patent: 2198
Patent: SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE
Estimated Expiration: ⤷ Sign Up
Patent: 201509887U
Patent: SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE
Estimated Expiration: ⤷ Sign Up
Patent: 201912675V
Patent: SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE
Estimated Expiration: ⤷ Sign Up
Slovenia
Patent: 73752
Estimated Expiration: ⤷ Sign Up
Patent: 40731
Estimated Expiration: ⤷ Sign Up
Patent: 70090
Estimated Expiration: ⤷ Sign Up
South Africa
Patent: 0908826
Patent: SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTHYLPROPANEITRILE
Estimated Expiration: ⤷ Sign Up
South Korea
Patent: 1549876
Estimated Expiration: ⤷ Sign Up
Patent: 100049010
Patent: SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE
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Patent: 150036210
Patent: 야누스 키나제 억제제（Ｒ）―３―（４―（７Ｈ―피롤로［２，３－ｄ］피리미딘―4―일）―1Ｈ―피라졸―1―일）―３―사이클로펜틸프로판니트릴의 염 (Salts of the Janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile)
Estimated Expiration: ⤷ Sign Up
Spain
Patent: 67665
Estimated Expiration: ⤷ Sign Up
Patent: 75797
Estimated Expiration: ⤷ Sign Up
Patent: 14092
Estimated Expiration: ⤷ Sign Up
Patent: 03444
Estimated Expiration: ⤷ Sign Up
Tunisia
Patent: 09000514
Patent: SALTS OF THE JANUS KINASE INHIBITOR (R) -3-(4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE
Estimated Expiration: ⤷ Sign Up
Turkey
Patent: 1903488
Estimated Expiration: ⤷ Sign Up
Ukraine
Patent: 467
Patent: СОЛІ ІНГІБІТОРА ЯНУС-КІНАЗИ (R)-3-(4-(7H-ПІРОЛО[2,3-d]ПІРИМІДИН-4-ІЛ)-1H-ПІРАЗОЛ-1-ІЛ)-3-ЦИКЛОПЕНТИЛПРОПАННІТРИЛУ[СОЛИ ИНГИБИТОРА ЯНУС-КИНАЗЫ (R)-3-(4-(7H-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)-1H-ПИРАЗОЛ-1-ИЛ)-3-ЦИКЛОПЕНТИЛПРОПАННИТРИЛА (SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE)
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Generics may enter earlier, or later, based on new patent filings, patent extensions, patent invalidation, early generic licensing, generic entry preferences, and other factors.
See the table below for additional patents covering JAKAFI around the world.
| Country | Patent Number | Title | Estimated Expiration |
|---|---|---|---|
| Cyprus | 2013006 | ⤷ Sign Up | |
| China | 103524509 | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile | ⤷ Sign Up |
| Croatia | P20160717 | ⤷ Sign Up | |
| China | 101448826 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | ⤷ Sign Up |
| >Country | >Patent Number | >Title | >Estimated Expiration |
Supplementary Protection Certificates for JAKAFI
| Patent Number | Supplementary Protection Certificate | SPC Country | SPC Expiration | SPC Description |
|---|---|---|---|---|
| 1966202 | CR 2013 00005 | Denmark | ⤷ Sign Up | PRODUCT NAME: RUXOLITINIB, ELLER ET FARMACEUTISK ACCEPTABELT SALT DERAF, HERUNDER RUXOLITINIB PHOSFAT; REG. NO/DATE: EU/1/12/773/001-003 20120823 |
| 2455382 | 122017000020 | Germany | ⤷ Sign Up | PRODUCT NAME: RUXOLITINIB, ODER EIN PHARMAZEUTISCH AKZEPTABLES SALZ DAVON; REGISTRATION NO/DATE: EU/1/12/773/001-003 20150311 |
| 1966202 | 8/2013 | Austria | ⤷ Sign Up | PRODUCT NAME: RUXOLITINIB ODER EIN PHARMAZEUTISCH ANNEHMBARES SALZ DAVON; REGISTRATION NO/DATE: EU/1/12/773/001-003 20120823 |
| 2455382 | 300870 | Netherlands | ⤷ Sign Up | PRODUCT NAME: RUXOLITINIB OF EEN FARMACEUTISCH AANVAARDBAAR ZOUT DAARVAN; REGISTRATION NO/DATE: EU/1/12/773/001-016 20150313 |
| >Patent Number | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration | >SPC Description |
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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.
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