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IFEX Drug Profile

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When do Ifex patents expire, and what generic alternatives are available?

Ifex is a drug marketed by Baxter Hlthcare and is included in one NDA.

The generic ingredient in IFEX is ifosfamide; mesna. There are five drug master file entries for this compound. One supplier is listed for this compound. Additional details are available on the ifosfamide; mesna profile page.

Summary for IFEX

US Patents:	0
Applicants:	1
NDAs:	1
Suppliers / Packagers:	1
Bulk Api Vendors:	75
Patent Applications:	4,894
Formulation / Manufacturing:	see details
Drug Prices:	see details
DailyMed Link:	IFEX at DailyMed

Pharmacology for IFEX

Drug Class	Alkylating Drug
Mechanism of Action	Alkylating Activity

Synonyms for IFEX

(+-)-Ifosfamid

(+-)-Ifosphamide

(+-)-Tetrahydro-N,3-bis(2-chloroethyl)-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

(2S)-3-(2-chloroethyl)-2-[(2-chloroethyl)amino]-1,3,2|E5-oxazaphosphinan-2-one

(D,L)-Ifosfamide

(R,S)-Ifosphamide

(R,S)-N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

(R)-Ifosfamide

(S)-Ifosfamide

{3-(2-Chloroethyl)-2-[(2-

{3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,} 2-oxazaphosphorine oxide

1,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide

1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide

1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide

2,3-(N,N(sup 1)-Bis(2-chloroethyl)diamido)-1,3,2-oxazaphosphoridinoxyd

2,3-N,N(sup 1)-Bis(2-chloroethyl)diamido-1,3,2-oxazaphosphoridinoxy-

2,3-N,N(sup 1)-Bis(2-chloroethyl)diamido-1,3,2-oxazaphosphoridinoxyd

2,N(sup 1)-Bis(2-chloroethyl)diamido-1,3,2-oxazaphosphoridinoxy-

2,N(sup 1)-Bis(2-chloroethyl)diamido-1,3,2-oxazaphosphoridinoxyd

2H-1,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide

2H-1,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide

2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis( 2-chloroethyl)tetrahydro-, 2-oxide

2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide

2H-1,3,2-Oxazaphosphorin-2-amine, tetrahydro-N,3-bis(2-chloroethyl)-, 2-oxide, (+-)-

2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide

2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide (8CI)

2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide

3-(2-chloroethyl)-2-((2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide

3-(2-Chloroethyl)-2-((2-chloroethyl)amino)perhydro-2H-1,3,2-oxazaphosphorine oxide

3-(2-Chloroethyl)-2-((2-chloroethyl)amino)perhydro-2H-1,3,2-oxazaphosphorineoxide

3-(2-Chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide

3-(2-Chloroethyl)-2-(2-chloroethylamino)tetrahydro-2H-1,3,2-oxazaphosphorin-2-one

3-(2-chloroethyl)-2-[(2-chloroethyl)amino]-1,3,2$l;{5}-oxazaphosphinan-2-one

3-(2-chloroethyl)-2-[(2-chloroethyl)amino]-1,3,2lambda5-oxazaphosphinan-2-one

3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,2-oxazaphosphorine oxide

3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,2-oxazaphosphorineoxide

3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,2-oxazaphosphorine oxide

3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,2-oxazaphosphorineoxide

3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,2-oxazaphosphorine 2-oxide

3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2- oxide

3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide

3,} 2-oxazaphosphorine oxide

33899-EP2275420A1

33899-EP2295055A2

33899-EP2295416A2

33899-EP2298748A2

33899-EP2298764A1

33899-EP2298765A1

33899-EP2305642A2

33899-EP2311453A1

36341-88-5

3778-73-2

778I732

84711-20-6

A 4942

AB0008491

AB00513932

AB00513932_09

AB00513932_10

AB00513932-06

AB00513932-07

AB00513932-08

AB02316

AB2000039

AC-2113

AC1L1GHW

ACM1189701130

AKOS005711213

Ambap3778-73-2

AN-6958

API0002976

AS-10978

ASTA Z 4942

BBL028071

BDBM189358

BPBio1_000865

BRD-A67097164-001-11-2

BRN 0611835

BSPBio_000785

C-16296

C07047

C7H15Cl2N2O2P

CAS-3778-73-2

CC-29468

CCG-213464

CCRIS 352

CHEBI:5864

CHEMBL1024

CI0037

CS-1424

CTK8E8347

Cyfos

D00343

D02TLO

DB01181

dexifosfamide

DR000765

DSSTox_CID_760

DSSTox_GSID_20760

DSSTox_RID_75775

DTXSID7020760

EINECS 223-237-3

FT-0603650

GTPL7201

HE300382

HE339529

HMS1570H07

HMS2090M12

HMS2093N07

HMS2097H07

HMS2232O10

HMS3374B08

HMS3654B15

Holoxan

Holoxan 1000

HOMGKSMUEGBAAB-UHFFFAOYSA-N

HSDB 7023

HY-17419

I-Phosphamide

I06-0494

IFEX (TN)

Ifex (TN) (Bristol Meyers)

ifomide

Ifosfamid

Ifosfamid A

Ifosfamida

Ifosfamida [INN-Spanish]

ifosfamide

Ifosfamide (JAN/USP/INN)

Ifosfamide [USAN:INN:BAN:JAN]

Ifosfamide [USAN:USP:INN:BAN:JAN]

Ifosfamide Sterile

Ifosfamide, >=98%

Ifosfamide, analytical reference material

Ifosfamide, British Pharmacopoeia (BP) Reference Standard

Ifosfamide, European Pharmacopoeia (EP) Reference Standard

Ifosfamide, United States Pharmacopeia (USP) Reference Standard

Ifosfamidum

Ifosfamidum [INN-Latin]

ifosfomide

Ifosphamide

Ifsofamide

Iphosphamid

Iphosphamid(e)

Iphosphamide

Iso Endoxan

Iso-Endoxan

Isoendoxan

Isofosfamide

Isophosphamide

isosfamide

J10093

KB-333868

KS-00000YBW

KSC948G4P

LS-102

LS-99799

M-1494

MCULE-1480299331

MFCD00057374

Mitoxana

Mitoxana (TN)

Mitoxana, Ifex, Ifosfamide

Mitoxana;Ifex

MJF 9325

MJF-9325

MLS002154021

MolPort-003-666-704

N-(2-Chloraethyl)-N'-(2-chloraethyl)-N',O-propylen-phosphorsaureester-diamid

N-(2-Chloraethyl)-N'-(2-chloraethyl)-N',O-propylen-phosphorsaureester-diamid [German]

N-(2-Chloroethyl)-N-(3-(2-chloroethyl)-2-oxido-1,3,2-oxazaphosphinan-2-yl)amine

N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylen ephosphoric acid diamide

N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylene phosphoric acid ester diamide

N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid diamide

N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide

N,3-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide

N,3-bis(2-chloroethyl)-2-oxo-1,3,2?^{5}-oxazaphosphinan-2-amine

N,3-bis(2-chloroethyl)-2-oxo-1,3,2$l^{5}-oxazaphosphinan-2-amine

N,3-bis(2-chloroethyl)-2-oxo-1,3,2$l;{5}-oxazaphosphinan-2-amine

N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphinan-2-amine 2-oxide #

N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

N,N-Bis(beta-chloroethyl)-amino-N',O-propylene-phosphoric acid ester diamide

Naxamide

NCGC00016639-01

NCGC00179435-01

NCGC00179435-02

NCGC00179435-03

NCGC00179435-06

NCGC00179435-07

NCGC00256413-01

NCGC00259364-01

NCI-C01638

NCI60_000233

NPFAPI-04

NSC 109724

NSC-109,724

NSC-109724

NSC-759154

NSC109724

NSC759154

Pharmakon1600-01505480

Prestwick0_000833

Prestwick1_000833

Prestwick2_000833

Prestwick3_000833

Q-101874

s1302

SBI-0206804.P001

SC-12120

SCHEMBL4885

SMR001233348

SPBio_002706

SR-05000002022

SR-05000002022-5

STL058690

TA-01010

Tox21_110539

Tox21_110539_1

Tox21_201815

Tox21_302775

UNII-UM20QQM95Y component HOMGKSMUEGBAAB-AWEZNQCLSA-N

WLN: T6NPOTJ AM2G BO B2G

Z 4942

Z-4942

Z4942

US Patents and Regulatory Information for IFEX

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Baxter Hlthcare	IFEX	ifosfamide	INJECTABLE;INJECTION	019763-001	Dec 30, 1988	AP	RX	Yes	No
Baxter Hlthcare	IFEX/MESNEX KIT	ifosfamide; mesna	INJECTABLE;INJECTION	019763-004	Oct 10, 1992		DISCN	No	No
Baxter Hlthcare	IFEX	ifosfamide	INJECTABLE;INJECTION	019763-002	Dec 30, 1988	AP	RX	Yes	No
Baxter Hlthcare	IFEX/MESNEX KIT	ifosfamide; mesna	INJECTABLE;INJECTION	019763-003	Oct 10, 1992		DISCN	No	No

Expired US Patents for IFEX

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	Patent No.	Patent Expiration
Baxter Hlthcare	IFEX	ifosfamide	INJECTABLE;INJECTION	019763-002	Dec 30, 1988
Baxter Hlthcare	IFEX	ifosfamide	INJECTABLE;INJECTION	019763-002	Dec 30, 1988
Baxter Hlthcare	IFEX	ifosfamide	INJECTABLE;INJECTION	019763-001	Dec 30, 1988
Baxter Hlthcare	IFEX	ifosfamide	INJECTABLE;INJECTION	019763-001	Dec 30, 1988