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Last Updated: October 7, 2024

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EUCRISA Drug Patent Profile


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Which patents cover Eucrisa, and what generic alternatives are available?

Eucrisa is a drug marketed by Anacor Pharms Inc and is included in one NDA. There are four patents protecting this drug and one Paragraph IV challenge.

This drug has one hundred and forty-eight patent family members in twenty-eight countries.

The generic ingredient in EUCRISA is crisaborole. There are three drug master file entries for this compound. One supplier is listed for this compound. Additional details are available on the crisaborole profile page.

DrugPatentWatch® Generic Entry Outlook for Eucrisa

Eucrisa was eligible for patent challenges on December 14, 2020.

By analyzing the patents and regulatory protections it appears that the earliest date for generic entry will be December 29, 2029. This may change due to patent challenges or generic licensing.

There have been five patent litigation cases involving the patents protecting this drug, indicating strong interest in generic launch. Recent data indicate that 63% of patent challenges are decided in favor of the generic patent challenger and that 54% of successful patent challengers promptly launch generic drugs.

Indicators of Generic Entry

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Drug patent expirations by year for EUCRISA
Drug Prices for EUCRISA

See drug prices for EUCRISA

DrugPatentWatch® Estimated Loss of Exclusivity (LOE) Date for EUCRISA
Generic Entry Date for EUCRISA*:
Constraining patent/regulatory exclusivity:
NDA:
Dosage:
OINTMENT;TOPICAL

*The generic entry opportunity date is the latter of the last compound-claiming patent and the last regulatory exclusivity protection. Many factors can influence early or later generic entry. This date is provided as a rough estimate of generic entry potential and should not be used as an independent source.

Recent Clinical Trials for EUCRISA

Identify potential brand extensions & 505(b)(2) entrants

SponsorPhase
University of Colorado, DenverPhase 2
Boston UniversityPhase 4
Applied Biology, Inc.Phase 3

See all EUCRISA clinical trials

Pharmacology for EUCRISA
Paragraph IV (Patent) Challenges for EUCRISA
Tradename Dosage Ingredient Strength NDA ANDAs Submitted Submissiondate
EUCRISA Topical Ointment crisaborole 2% 207695 5 2021-06-14

US Patents and Regulatory Information for EUCRISA

EUCRISA is protected by four US patents and one FDA Regulatory Exclusivity.

Based on analysis by DrugPatentWatch, the earliest date for a generic version of EUCRISA is ⤷  Sign Up.

This potential generic entry date is based on patent ⤷  Sign Up.

Generics may enter earlier, or later, based on new patent filings, patent extensions, patent invalidation, early generic licensing, generic entry preferences, and other factors.

Patents protecting EUCRISA

Boron-containing small molecules
Patent Number: ⤷  Sign Up
Patent Expiration: ⤷  Sign Up

Boron-containing small molecules as anti-inflammatory agents
Patent Number: ⤷  Sign Up
Patent Expiration: ⤷  Sign Up

Boron-containing small molecules as anti-inflammatory agents
Patent Number: ⤷  Sign Up
Patent Expiration: ⤷  Sign Up

Boron-containing small molecules as anti-inflammatory agents
Patent Number: ⤷  Sign Up
Patent Expiration: ⤷  Sign Up

FDA Regulatory Exclusivity protecting EUCRISA

ADDITION OF A ONCE DAILY DOSING REGIMEN
Exclusivity Expiration: ⤷  Sign Up

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Anacor Pharms Inc EUCRISA crisaborole OINTMENT;TOPICAL 207695-001 Dec 14, 2016 RX Yes Yes ⤷  Sign Up ⤷  Sign Up Y ⤷  Sign Up
Anacor Pharms Inc EUCRISA crisaborole OINTMENT;TOPICAL 207695-001 Dec 14, 2016 RX Yes Yes ⤷  Sign Up ⤷  Sign Up Y ⤷  Sign Up
Anacor Pharms Inc EUCRISA crisaborole OINTMENT;TOPICAL 207695-001 Dec 14, 2016 RX Yes Yes ⤷  Sign Up ⤷  Sign Up Y ⤷  Sign Up
Anacor Pharms Inc EUCRISA crisaborole OINTMENT;TOPICAL 207695-001 Dec 14, 2016 RX Yes Yes ⤷  Sign Up ⤷  Sign Up Y ⤷  Sign Up
Anacor Pharms Inc EUCRISA crisaborole OINTMENT;TOPICAL 207695-001 Dec 14, 2016 RX Yes Yes ⤷  Sign Up ⤷  Sign Up ⤷  Sign Up
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

EU/EMA Drug Approvals for EUCRISA

Company Drugname Inn Product Number / Indication Status Generic Biosimilar Orphan Marketing Authorisation Marketing Refusal
Pfizer Europe MA EEIG  Staquis crisaborole EMEA/H/C/004863
Staquis is indicated for treatment of mild to moderate atopic dermatitis in adults and paediatric patients from 2 years of age with ≤ 40% body surface area (BSA) affected.
Withdrawn no no no 2020-03-27
>Company >Drugname >Inn >Product Number / Indication >Status >Generic >Biosimilar >Orphan >Marketing Authorisation >Marketing Refusal

International Patents for EUCRISA

When does loss-of-exclusivity occur for EUCRISA?

Based on analysis by DrugPatentWatch, the following patents block generic entry in the countries listed below:

Australia

Patent: 06214247
Patent: Boron-containing small molecules
Estimated Expiration: ⤷  Sign Up

Patent: 06333527
Patent: Boron-containing small molecules
Estimated Expiration: ⤷  Sign Up

Patent: 10203096
Patent: Boron-containing small molecules
Estimated Expiration: ⤷  Sign Up

Patent: 11200994
Patent: Boron-containing small molecules
Estimated Expiration: ⤷  Sign Up

Brazil

Patent: 0608431
Patent: móleculas pequenas contendo boro
Estimated Expiration: ⤷  Sign Up

Patent: 0621279
Patent: moléculas pequenas contendo boro
Estimated Expiration: ⤷  Sign Up

Canada

Patent: 97982
Patent: PETITES MOLECULES CONTENANT DU BORE (BORON-CONTAINING SMALL MOLECULES)
Estimated Expiration: ⤷  Sign Up

Patent: 35680
Patent: PETITES MOLECULES CONTENANT DU BORE (BORON-CONTAINING SMALL MOLECULES)
Estimated Expiration: ⤷  Sign Up

China

Patent: 1160124
Patent: Boron-containing small molecules
Estimated Expiration: ⤷  Sign Up

Patent: 1505603
Patent: Boron-containing small molecules
Estimated Expiration: ⤷  Sign Up

Patent: 1914109
Patent: Boron-containing small molecules
Estimated Expiration: ⤷  Sign Up

Patent: 2532180
Patent: Boron-containing small molecules
Estimated Expiration: ⤷  Sign Up

Patent: 5949230
Patent: 含硼的小分子 (BORON-CONTAINING SMALL MOLECULES)
Estimated Expiration: ⤷  Sign Up

Patent: 6008571
Patent: 含硼的小分子 (Boron-containing small molecules)
Estimated Expiration: ⤷  Sign Up

Patent: 6008583
Patent: 含硼的小分子 (BORON-CONTAINING SMALL MOLECULES)
Estimated Expiration: ⤷  Sign Up

Cyprus

Patent: 16454
Estimated Expiration: ⤷  Sign Up

Patent: 20695
Estimated Expiration: ⤷  Sign Up

Patent: 24503
Estimated Expiration: ⤷  Sign Up

Patent: 20027
Estimated Expiration: ⤷  Sign Up

Denmark

Patent: 43304
Estimated Expiration: ⤷  Sign Up

Patent: 87796
Estimated Expiration: ⤷  Sign Up

Patent: 24932
Estimated Expiration: ⤷  Sign Up

European Patent Office

Patent: 53251
Patent: BORONOPHTHALIDES SUBSTITUES PAR HALOGENE POUR LE TRAITEMENT D'INFECTIONS (HALOGEN-SUBSTITUTED BORONOPHTHALIDES FOR THE TREATMENT OF INFECTIONS)
Estimated Expiration: ⤷  Sign Up

Patent: 76536
Patent: PETITES MOLECULES CONTENANT DU BORE (BORON-CONTAINING SMALL MOLECULES)
Estimated Expiration: ⤷  Sign Up

Patent: 43304
Patent: Composés boronophthalide biocides (Biocidal boronophthalide compounds)
Estimated Expiration: ⤷  Sign Up

Patent: 87796
Patent: BORONOPHTHALIDES SUBSTITUES PAR HALOGENE POUR LE TRAITEMENT D'INFECTIONS (HALOGEN-SUBSTITUTED BORONOPHTHALIDES FOR THE TREATMENT OF INFECTIONS)
Estimated Expiration: ⤷  Sign Up

Patent: 24932
Patent: BORONOPHTHALIDES À USAGE THÉRAPEUTIQUE (BORONOPHTHALIDES FOR THERAPEUTIC USE)
Estimated Expiration: ⤷  Sign Up

France

Patent: C1024
Estimated Expiration: ⤷  Sign Up

Hong Kong

Patent: 09735
Patent: HALOGEN-SUBSTITUTED BORONOPHTHALIDES FOR THE TREATMENT OF INFECTIONS
Estimated Expiration: ⤷  Sign Up

Patent: 60139
Patent: 殺生物二羥硼基 -苯並 呋喃酮化合物 (BIOCIDAL BORONOPHTHALIDE COMPOUNDS 2-[C])
Estimated Expiration: ⤷  Sign Up

Patent: 21956
Patent: 用於治療感染的鹵代類苯酞化硼 (HALOGEN-SUBSTITUTED BORONOPHTHALIDES FOR THE TREATMENT OF INFECTIONS)
Estimated Expiration: ⤷  Sign Up

Patent: 28917
Patent: 含硼的小分子 (BORON-CONTAINING SMALL MOLECULES)
Estimated Expiration: ⤷  Sign Up

Hungary

Patent: 26021
Estimated Expiration: ⤷  Sign Up

Patent: 40060
Estimated Expiration: ⤷  Sign Up

Patent: 54365
Estimated Expiration: ⤷  Sign Up

Patent: 000019
Estimated Expiration: ⤷  Sign Up

Israel

Patent: 5080
Patent: BORON-CONTAINING SMALL MOLECULES, PHARMACEUTICAL FORMULATIONS COMPRISING THEM AND USE THEREOF IN THE PREPARATION OF MEDICAMENTS FOR TREATING INFECTIONS
Estimated Expiration: ⤷  Sign Up

Patent: 2402
Patent: מולקולות קטנות המכילות בורון (Boron-containing small molecules)
Estimated Expiration: ⤷  Sign Up

Patent: 7156
Patent: מולקולות קטנות המכילות בור (Boron-containing small molecules)
Estimated Expiration: ⤷  Sign Up

Japan

Patent: 38912
Estimated Expiration: ⤷  Sign Up

Patent: 46876
Estimated Expiration: ⤷  Sign Up

Patent: 09140
Estimated Expiration: ⤷  Sign Up

Patent: 08535781
Estimated Expiration: ⤷  Sign Up

Patent: 09526751
Estimated Expiration: ⤷  Sign Up

Patent: 10248265
Patent: BORON-CONTAINING SMALL MOLECULE
Estimated Expiration: ⤷  Sign Up

Patent: 13018778
Patent: BORON-CONTAINING SMALL MOLECULE
Estimated Expiration: ⤷  Sign Up

Patent: 14132031
Patent: BORON-CONTAINING SMALL MOLECULES
Estimated Expiration: ⤷  Sign Up

Patent: 15117243
Patent: ホウ素含有小分子 (BORON-CONTAINING SMALL MOLECULES)
Estimated Expiration: ⤷  Sign Up

Patent: 16020374
Patent: ホウ素含有小分子 (BORON-CONTAINING SMALL MOLECULE)
Estimated Expiration: ⤷  Sign Up

Patent: 16199561
Patent: ホウ素含有小分子 (BORON-CONTAINING SMALL MOLECULES)
Estimated Expiration: ⤷  Sign Up

Patent: 17105826
Patent: ホウ素含有小分子 (BORON-CONTAINING SMALL MOLECULE)
Estimated Expiration: ⤷  Sign Up

Lithuania

Patent: 343304
Estimated Expiration: ⤷  Sign Up

Patent: 2020524
Estimated Expiration: ⤷  Sign Up

Luxembourg

Patent: 0157
Estimated Expiration: ⤷  Sign Up

Mexico

Patent: 5993
Patent: MOLECULAS PEQUEÑAS QUE CONTIENEN BORO. (BORON-CONTAINING SMALL MOLECULES.)
Estimated Expiration: ⤷  Sign Up

Patent: 9262
Patent: MOLECULAS PEQUEÑAS QUE CONTIENEN BORO. (BORON-CONTAINING SMALL MOLECULES.)
Estimated Expiration: ⤷  Sign Up

Netherlands

Patent: 1049
Estimated Expiration: ⤷  Sign Up

New Zealand

Patent: 0448
Patent: Boron-containing small molecules
Estimated Expiration: ⤷  Sign Up

Patent: 8297
Patent: Boron-containing small molecules
Estimated Expiration: ⤷  Sign Up

Patent: 8441
Patent: BORON-CONTAINING SMALL MOLECULES
Estimated Expiration: ⤷  Sign Up

Poland

Patent: 53251
Estimated Expiration: ⤷  Sign Up

Patent: 43304
Estimated Expiration: ⤷  Sign Up

Patent: 87796
Estimated Expiration: ⤷  Sign Up

Patent: 24932
Estimated Expiration: ⤷  Sign Up

Portugal

Patent: 53251
Estimated Expiration: ⤷  Sign Up

Patent: 43304
Estimated Expiration: ⤷  Sign Up

Patent: 87796
Estimated Expiration: ⤷  Sign Up

Patent: 24932
Estimated Expiration: ⤷  Sign Up

Russian Federation

Patent: 14906
Patent: БОРСОДЕРЖАЩИЕ МАЛЫЕ МОЛЕКУЛЫ (BORON-CONTAINING SMALL MOLLECULES)
Estimated Expiration: ⤷  Sign Up

Patent: 06947
Patent: БОРСОДЕРЖАЩИЕ МАЛЫЕ МОЛЕКУЛЫ (BORON-CONTAINING SMALL MOLECULES)
Estimated Expiration: ⤷  Sign Up

Patent: 07134429
Patent: БОРСОДЕРЖАЩИЕ МАЛЫЕ МОЛЕКУЛЫ
Estimated Expiration: ⤷  Sign Up

Patent: 08131324
Patent: БОРСОДЕРЖАЩИЕ МАЛЫЕ МОЛЕКУЛЫ
Estimated Expiration: ⤷  Sign Up

Patent: 10133524
Patent: БОРСОДЕРЖАЩИЕ МАЛЫЕ МОЛЕКУЛЫ
Estimated Expiration: ⤷  Sign Up

Patent: 16145916
Patent: БОРСОДЕРЖАЩИЕ МАЛЫЕ МОЛЕКУЛЫ
Estimated Expiration: ⤷  Sign Up

Slovenia

Patent: 43304
Estimated Expiration: ⤷  Sign Up

Patent: 87796
Estimated Expiration: ⤷  Sign Up

Patent: 24932
Estimated Expiration: ⤷  Sign Up

South Africa

Patent: 0707408
Patent: Boron-containing small molecules
Estimated Expiration: ⤷  Sign Up

Patent: 0905950
Patent: BORON-CONTAINING SMALL MOLECULES
Estimated Expiration: ⤷  Sign Up

Patent: 1005380
Patent: BORON-CONTAINING SMALL MOLECULES
Estimated Expiration: ⤷  Sign Up

Patent: 1506944
Patent: BORON-CONTAINING SMALL MOLECULES
Estimated Expiration: ⤷  Sign Up

South Korea

Patent: 1337045
Estimated Expiration: ⤷  Sign Up

Patent: 1337068
Estimated Expiration: ⤷  Sign Up

Patent: 1426220
Estimated Expiration: ⤷  Sign Up

Patent: 1456815
Estimated Expiration: ⤷  Sign Up

Patent: 070112390
Patent: BORON-CONTAINING SMALL MOLECULES
Estimated Expiration: ⤷  Sign Up

Patent: 080110984
Patent: BORON-CONTAINING SMALL MOLECULES
Estimated Expiration: ⤷  Sign Up

Patent: 100105869
Patent: BORON-CONTAINING SMALL MOLECULES
Estimated Expiration: ⤷  Sign Up

Patent: 130095330
Patent: BORON-CONTAINING SMALL MOLECULES
Estimated Expiration: ⤷  Sign Up

Patent: 130100019
Patent: BORON-CONTAINING SMALL MOLECULES
Estimated Expiration: ⤷  Sign Up

Spain

Patent: 14095
Estimated Expiration: ⤷  Sign Up

Patent: 40966
Estimated Expiration: ⤷  Sign Up

Patent: 86981
Estimated Expiration: ⤷  Sign Up

Patent: 72962
Estimated Expiration: ⤷  Sign Up

Generics may enter earlier, or later, based on new patent filings, patent extensions, patent invalidation, early generic licensing, generic entry preferences, and other factors.

See the table below for additional patents covering EUCRISA around the world.

Country Patent Number Title Estimated Expiration
South Korea 101622870 ⤷  Sign Up
Denmark 3424932 ⤷  Sign Up
Brazil PI0621279 moléculas pequenas contendo boro ⤷  Sign Up
Japan 5038912 ⤷  Sign Up
South Korea 20130100019 BORON-CONTAINING SMALL MOLECULES ⤷  Sign Up
>Country >Patent Number >Title >Estimated Expiration

Supplementary Protection Certificates for EUCRISA

Patent Number Supplementary Protection Certificate SPC Country SPC Expiration SPC Description
2343304 20C1024 France ⤷  Sign Up PRODUCT NAME: CRISABOROLE, OPTIONNELLEMENT SOUS LA FORME D'UN SEL PHARMACEUTIQUEMENT ACCEPTABLE; REGISTRATION NO/DATE: EU/1/19/1421 20200401
2343304 PA2020524 Lithuania ⤷  Sign Up PRODUCT NAME: KRISABOROLAS, PASIRINKTINAI FARMACINIU POZIURIU PRIIMTINOS DRUSKOS FORMOJE; REGISTRATION NO/DATE: EU/1/19/1421 20200327
2343304 23/2020 Austria ⤷  Sign Up PRODUCT NAME: CRISABOROL, GEGEBENENFALLS IN FORM EINES PHARMAZEUTISCH AKZEPTABLEN SALZES; REGISTRATION NO/DATE: EU/1/19/1421 (MITTEILUNG) 20200401
2343304 CA 2020 00022 Denmark ⤷  Sign Up PRODUCT NAME: CRISABOROLE, EVENTUELT I FORM AF ET FARMACEUTISK ACCEPTABELT SALT DERAF; REG. NO/DATE: EU/1/19/1421 20200401
2343304 SPC/GB20/025 United Kingdom ⤷  Sign Up PRODUCT NAME: CRISABOROLE, OPTIONALLY IN THE FORM OF A PHARMACEUTICALLY ACCEPTABLE SALT; REGISTERED: UK EU/1/19/1421 20200401; UK PLGB 00057-1691 20200401
>Patent Number >Supplementary Protection Certificate >SPC Country >SPC Expiration >SPC Description

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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.