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Last Updated: December 15, 2025

Suppliers and packagers for generic pharmaceutical drug: MENTHOL; METHYL SALICYLATE


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MENTHOL; METHYL SALICYLATE

Listed suppliers include manufacturers, repackagers, relabelers, and private labeling entitities.

Applicant Tradename Generic Name Dosage NDA NDA/ANDA Supplier Package Code Package Marketing Start
Hisamitsu Pharm Co SALONPAS menthol; methyl salicylate PATCH;TOPICAL 022029 NDA Hisamitsu Pharmaceutical Co., Inc. 46581-670-01 1 PATCH in 1 POUCH (46581-670-01) 2008-04-25
Hisamitsu Pharm Co SALONPAS menthol; methyl salicylate PATCH;TOPICAL 022029 NDA Hisamitsu Pharmaceutical Co., Inc. 46581-670-03 3 PATCH in 1 POUCH (46581-670-03) 2008-04-25
Hisamitsu Pharm Co SALONPAS menthol; methyl salicylate PATCH;TOPICAL 022029 NDA Hisamitsu Pharmaceutical Co., Inc. 46581-670-05 1 POUCH in 1 BOX (46581-670-05) / 5 PATCH in 1 POUCH 2008-04-25
Hisamitsu Pharm Co SALONPAS menthol; methyl salicylate PATCH;TOPICAL 022029 NDA Hisamitsu Pharmaceutical Co., Inc. 46581-670-06 2 POUCH in 1 BOX (46581-670-06) / 3 PATCH in 1 POUCH 2008-04-25
Hisamitsu Pharm Co SALONPAS menthol; methyl salicylate PATCH;TOPICAL 022029 NDA Hisamitsu Pharmaceutical Co., Inc. 46581-670-15 3 POUCH in 1 BOX (46581-670-15) / 5 PATCH in 1 POUCH 2008-04-25
>Applicant >Tradename >Generic Name >Dosage >NDA >NDA/ANDA >Supplier >Package Code >Package >Marketing Start

Suppliers of the Pharmaceutical Drugs: Menthol and Methyl Salicylate

Last updated: July 28, 2025

Introduction

Menthol and methyl salicylate are widely used pharmaceutical ingredients with extensive applications in analgesics, topical analgesic formulations, and aroma-based therapies. Their sourcing is critical for manufacturers aiming to ensure product quality, regulatory compliance, and cost-effectiveness. Understanding the global landscape of suppliers provides strategic insights into procurement, risk mitigation, and market trends. This article examines the primary suppliers of menthol and methyl salicylate, analyzing their production capacities, regional presence, and industry influence.

Menthol Suppliers: Market Overview

Menthol, a cyclic monoterpene alcohol, is predominantly extracted from natural sources such as peppermint (Mentha piperita), cornmint (Mentha arvensis), and other mint species. Its cooling sensation makes it a staple in pharmaceutical, oral care, and flavoring sectors.

Natural vs. Synthetic Menthol Production

Natural menthol retains high market value due to consumer preference for natural ingredients, but synthetic menthol accounts for approximately 60%-70% of global supply, mainly due to stability and cost benefits. Synthetic menthol is primarily produced via catalytic hydrogenation of thymol or through chemical synthesis pathways involving citronellal.

Leading Menthol Suppliers

1. Symrise AG (Germany)

Symrise is one of the world's most prominent flavor and aroma companies, producing high-quality natural and synthetic menthol. Its vertically integrated supply chain, from cultivation to processing, ensures product consistency. Symrise focuses heavily on natural menthols derived from peppermint oils and is well-recognized for sustainability initiatives.

2. Givaudan SA (Switzerland)

Givaudan supplies both natural and synthetic menthols, leveraging advanced extraction technologies from peppermint and cornmint. The company emphasizes renewable sourcing and high purity standards, positioning itself as a leader in premium menthol ingredients.

3. Devyani International Pvt. Ltd. (India)

India is a major supplier of menthol, particularly through companies like Devyani International, which sources menthol largely from mentha arvensis cultivated predominantly in the Himalayan belts. India accounts for nearly 70% of the world's menthol production, with key players such as Devyani and other local entities dominating the market.

4. Indian Chemical Manufacturers

Several Indian firms, including Arora Menthols Pvt Ltd and Himalaya Menthols, supply menthol to global markets. Their competitive pricing and large-scale cultivation make India a critical player in global menthol supply chains.

5. International Menthol Producers

Other notable suppliers include companies such as Philip Harris and Wilmar International, which operate manufacturing units or import menthol for processing and distribution to global markets.

Regional Trends

  • Asia-Pacific: Dominates in menthol production, primarily due to large-scale mentha arvensis cultivation.
  • Europe & North America: Focuses on refined, natural menthols catering to premium markets. Givaudan and Symrise dominate in these regions.

Methyl Salicylate Suppliers: Market Overview

Methyl salicylate, known as wintergreen oil, is an aromatic ester used extensively in topical analgesics, flavorings, and perfumery. It is both derived from natural wintergreen oil (Gaultheria procumbens) and produced synthetically.

Natural vs. Synthetic Methyl Salicylate

Natural methyl salicylate is extracted from wintergreen leaves, but synthetic production is predominant due to higher yields and lower costs, achieved via esterification of salicylic acid with methanol.

Key Suppliers of Methyl Salicylate

1. Ferrer International (Spain)

Ferrer is a leading manufacturer specializing in methyl salicylate, with facilities producing high-purity natural and synthetic variants. The company emphasizes pharmaceutical-grade standards, primarily supplying topical analgesics and flavoring industries.

2. Celanese Corporation (USA)

Celanese supplies methyl salicylate as part of its aromatic chemicals portfolio. It produces both natural and synthetic grades, leveraging chemical synthesis processes. They serve pharmaceutical and industrial applications globally.

3. Koster Keunen (USA)

Koster Keunen specializes in the supply of aromatic esters, including methyl salicylate. They source natural wintergreen oil and also offer synthetic grades for different applications, emphasizing consistency and purity.

4. Eastman Chemical Company (USA)

Eastman invests heavily in the production of methyl salicylate, primarily offering synthetic variants, with a focus on quality and regulatory compliance for pharmaceutical use.

5. Indian Suppliers

India is also a significant player in methyl salicylate supply, sourcing mainly from natural wintergreen oil and chemical synthesis routes. Companies like Fine Organics and Valiant Chemicals serve global markets with both natural and synthetic grades.

Regional Trends

  • North America: Dominates in natural wintergreen oil extraction, with companies like Eastman and Koster Keunen.
  • Asia-Pacific: Increasing production capacity for synthetic methyl salicylate due to cost advantages, with India and China expanding their manufacturing footprint.

Supply Chain Dynamics and Market Considerations

Quality Standards and Regulatory Compliance

Suppliers of menthol and methyl salicylate predominantly adhere to pharmaceutical standards such as the United States Pharmacopeia (USP), European Pharmacopoeia (EP), and other regional certifications. This is critical given their application in medicinal products.

Price Fluctuations and Raw Material Dependencies

Menthol prices are influenced by agricultural yields, climate conditions, and geopolitical factors affecting mentha cultivation regions. Methyl salicylate, dependent on both natural oil extraction and chemical synthesis, faces price volatility based on availability and crude oil derivatives.

Sustainability and Ethical Sourcing

Consumers and regulators increasingly demand sustainably sourced ingredients. Suppliers investing in environmentally friendly cultivation, eco-certified plantations, and clean manufacturing practices are gaining market advantage.

Conclusion

The landscape of pharmaceutical menthol and methyl salicylate suppliers is characterized by a blend of global corporations, regional players, and specialized manufacturers. India’s dominance in menthol production remains uncontested, while Europe and North America lead in high-purity, natural, and pharmaceutical-grade ingredients. Synthetically produced methyl salicylate is favored for cost efficiency, with North American and Asian suppliers expanding capacities.

Ensuring consistent quality, sustainable sourcing, and compliance with regulatory standards are paramount for pharmaceutical manufacturers. Strategic supplier selection should evaluate manufacturing scalability, regulatory adherence, and supply chain resilience.


Key Takeaways

  • India leads global menthol supply, driven by large-scale mentha arvensis cultivation, with major players including Devyani International.
  • Natural menthol commands a premium in markets demanding higher purity, primarily supplied by Symrise and Givaudan.
  • Synthetic menthol dominates due to cost efficiencies, produced via catalytic hydrogenation or chemical synthesis in Europe, North America, and Asia.
  • Methyl salicylate production hinges on both natural wintergreen oil extraction and chemical synthesis, with Eastman, Koster Keunen, and Ferrer as primary suppliers.
  • Regulatory compliance and sustainability are core factors influencing supplier relationships in the pharmaceutical sector.

FAQs

1. What are the primary raw materials used in the production of menthol and methyl salicylate?
Menthol is predominantly derived from peppermint or cornmint oils, while methyl salicylate is synthesized chemically from salicylic acid and methanol or extracted from wintergreen oil.

2. Which regions dominate the global supply of menthol and methyl salicylate?
India dominates menthol production, accounting for up to 70% of global output. North America and Europe lead in high-purity, pharmaceutical-grade methyl salicylate, complemented by expanding Asian capacities.

3. Are natural or synthetic versions of these compounds preferred in pharmaceuticals?
Natural versions are often preferred for high-end, consumer-facing products due to consumer demand for natural ingredients, although synthetic variants dominate due to cost advantages and supply stability.

4. How do regulatory standards impact supplier selection?
Suppliers must comply with pharmacopoeial standards such as USP or EP to ensure safety, efficacy, and regulatory approval, influencing procurement decisions in pharmaceutical manufacturing.

5. What sustainability practices are being adopted by leading suppliers?
Leading companies engage in sustainable cultivation, eco-friendly extraction processes, and certification schemes like Fair Trade or Organic to meet consumer and regulatory expectations.


Sources:

  1. Symrise Sustainability Report 2022
  2. Givaudan Annual Report 2022
  3. Indian Essential Oil Industry Report
  4. Ferrer International Corporate Data
  5. Eastman Chemical Company Product Portfolio

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