Suppliers and packagers for generic pharmaceutical drug: ANGIOTENSIN II ACETATE

ANGIOTENSIN II ACETATE

Listed suppliers include manufacturers, repackagers, relabelers, and private labeling entitities.

Applicant	Tradename	Generic Name	Dosage	NDA	NDA/ANDA	Supplier	Package Code	Package	Marketing Start
Gland	ANGIOTENSIN LL ACETATE	angiotensin ii acetate	SOLUTION;INTRAVENOUS	216966	ANDA	Gland Pharma Limited	68083-553-01	1 VIAL, SINGLE-DOSE in 1 CARTON (68083-553-01) / 1 mL in 1 VIAL, SINGLE-DOSE	2025-06-03
La Jolla Pharma	GIAPREZA	angiotensin ii acetate	SOLUTION;INTRAVENOUS	209360	NDA	La Jolla Pharmaceutical Company	68547-005-01	1 VIAL, SINGLE-DOSE in 1 CARTON (68547-005-01) / 1 mL in 1 VIAL, SINGLE-DOSE	2022-09-15
La Jolla Pharma	GIAPREZA	angiotensin ii acetate	SOLUTION;INTRAVENOUS	209360	NDA	La Jolla Pharmaceutical Company	68547-501-02	1 VIAL, SINGLE-DOSE in 1 CARTON (68547-501-02) / 1 mL in 1 VIAL, SINGLE-DOSE	2018-02-05

Last updated: August 1, 2025

ppliers for the Pharmaceutical Drug: Angiotensin II Acetate

Introduction
Angiotensin II acetate, a synthetic analogue of the naturally occurring peptide angiotensin II, functions primarily as a potent vasoconstrictor. It is utilized in clinical settings predominantly for the rapid induction of vasoconstriction in cardiovascular support. With applications in diagnostics and certain therapeutic contexts, the manufacturing and supply chain of angiotensin II acetate remains critical. Ensuring reliable sources and understanding key suppliers is vital for pharmaceutical companies, healthcare institutions, and research organizations.

Overview of Angiotensin II Acetate
Angiotensin II acetate is a peptide hormone modified for increased stability and bioavailability. Its synthesis involves complex peptide chemistry, necessitating high purity and strict quality controls. As an active pharmaceutical ingredient (API), the supply chain involves raw material procurement, synthesis, purification, and packaging, often regulated by stringent quality standards like GMP (Good Manufacturing Practice).

Major Suppliers and Manufacturers of Angiotensin II Acetate

1. Synthesis and Manufacturing Companies

Several companies globally specialize in peptide synthesis and custom API manufacturing, including angiotensin II acetate. These firms often operate under strict regulatory compliance, offering APIs to pharmaceutical and biotech firms.

a. Bachem
Bachem, headquartered in Switzerland, is a leading manufacturer of peptides, including custom synthesis of complex peptides and APIs like angiotensin II acetate. Its focus on high-purity, GMP-compliant production makes it a reliable supplier for pharmaceutical partners. Bachem’s portfolio includes peptides used in cardiovascular research and clinical applications.

b. Peptide Technologies and SymBio
These regional firms in Asia offer peptide synthesis services with a focus on cardiovascular-related peptides. SymBio, based in Japan, supplies peptide APIs, including angiotensin II derivatives, to regional and international markets.

c. PolyPeptide Laboratories
An established player in peptide manufacturing, PolyPeptide Laboratories provides customized peptides for research, diagnostics, and therapeutic development, including angiotensin II analogs. Their manufacturing sites are GMP-certified, emphasizing quality and regulatory compliance.

2. Large-Scale Chemical and API Producers

Global chemical corporations with integrated capabilities in peptide synthesis and large-scale API production also supply angiotensin II acetate, primarily to institutional clients.

a. Novartis
While primarily known for its own drug portfolio, Novartis has historically engaged in peptide API supply via partnerships or licensing agreements. Their expertise in cardiovascular peptides positions them as a potential supplier or collaborator.

b. Teva Pharmaceutical Industries
Teva, with extensive experience in peptide APIs used in diagnostic and therapeutic applications, may supply angiotensin II acetate for research or clinical purposes. Their global manufacturing footprint underscores their capacity to serve large-volume demands.

3. Contract Manufacturing Organizations (CMOs)

CMOs offering peptide synthesis services cater to pharmaceutical companies seeking custom manufacturing, including angiotensin II acetate.

a. PolyPeptide Labs (in addition to direct production)
PolyPeptide’s contract services extend to GMP-compliant synthesis of complex peptides for clinical trials and commercial use.

b. WuXi AppTec
A prominent Asia-based CMO, WuXi offers peptide synthesis and API manufacturing services globally, including customized peptides like angiotensin II acetate, with high standards of quality control.

4. Distributors and Supply Chain Aggregators

For research-grade angiotensin II acetate, various material suppliers and chemical distributors provide procurement options.

a. Sigma-Aldrich (Merck)
Sigma-Aldrich supplies research-grade angiotensin II acetate in varying quantities, suitable for laboratory benchwork and preclinical studies. The company maintains high standards for purity and documentation.

b. Tocris Bioscience
Specializing in biological research reagents, Tocris offers angiotensin II acetate for experimental applications, emphasizing reliable supply and product quality.

5. Emerging Markets and Niche Suppliers

Growing regions have localized suppliers offering peptides, including angiotensin II derivatives, primarily for research and early-stage development. These sources often compete mainly on cost and lead times but may lack comprehensive regulatory approval for clinical use.

Regulatory and Quality Considerations
Suppliers of angiotensin II acetate must adhere to strict regulatory standards, including GMP for clinical and commercial API production. For research purposes, suppliers may provide materials with lesser regulatory oversight but must still ensure high purity and traceability. Due diligence involves verifying certifications, batch testing, and regulatory compliance.

Supply Chain Challenges
The complex synthesis of peptides like angiotensin II acetate makes sourcing subject to challenges such as raw material availability, synthesis complexity, potential contamination, and demand fluctuations. Supply disruptions can impact clinical trials, diagnostic use, and therapeutic applications. Working with established, regulatory-compliant manufacturers mitigates these risks.

Market Trends and Future Outlook
The increasing adoption of peptide-based therapeutics and diagnostics will likely stimulate demand for high-quality angiotensin II acetate. Advances in peptide synthesis technology and expanding manufacturing capacity in Asia and Europe enhance supply resilience. Additionally, strategic partnerships and licensing agreements are projected to facilitate broader availability.

Conclusion
Reliable sourcing of angiotensin II acetate hinges on engaging with reputable, GMP-compliant manufacturers and distributors. Global companies like Bachem, PolyPeptide Laboratories, WuXi AppTec, and Sigma-Aldrich represent primary options. Building a resilient supply chain ensures consistent supply, regulatory compliance, and quality assurance—critical factors in the pharmaceutical landscape.

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Key Takeaways

• Major suppliers include Bachem, PolyPeptide Laboratories, WuXi AppTec, and Sigma-Aldrich, each offering high-quality GMP-compliant angiotensin II acetate.
  -Engaging with established manufacturers reduces supply risks and ensures regulatory adherence.
• Custom peptide synthesis and contract manufacturing organizations are vital for clinical and research-grade materials.
• Supply chain resilience depends on understanding manufacturing complexity, raw material sourcing, and regulatory standards.
• Growth in peptide therapeutics signals increased demand and potential new suppliers in emerging markets.

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Frequently Asked Questions

Q1. Is angiotensin II acetate available for clinical use or only research purposes?
Angiotensin II acetate is primarily used for research, diagnostics, and clinical testing under strict regulatory controls. Its clinical use is generally limited to controlled settings, with manufacturers providing GMP-grade material compliant with pharmaceutical standards.

Q2. How can I verify the quality and regulatory compliance of angiotensin II acetate suppliers?
Verify supplier certifications such as GMP compliance, batch testing reports, purity percentages, and regulatory approvals (e.g., FDA registration). Request comprehensive documentation including Certificates of Analysis (CoA) and quality control data.

Q3. Are there regional differences in suppliers' capabilities for angiotensin II acetate?
Yes. European and North American suppliers typically lead in regulatory standards and GMP compliance, whereas Asian suppliers may offer competitive pricing and manufacturing scalability, with increasing adherence to global quality standards.

Q4. What are key considerations when sourcing angiotensin II acetate for pharmaceutical applications?
Prioritize suppliers with GMP certification, proven manufacturing experience, robust quality control procedures, and documented regulatory compliance to ensure product purity, stability, and traceability.

Q5. What emerging trends could impact the supply landscape of angiotensin II acetate?
Advancements in peptide synthesis technologies, increased demand for peptide-based therapies, regional manufacturing capacity expansion, and strategic collaborations are expected to influence supply dynamics positively.