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Last Updated: March 26, 2026

Details for Patent: 9,693,989


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Which drugs does patent 9,693,989 protect, and when does it expire?

Patent 9,693,989 protects TUKYSA and is included in one NDA.

This patent has fifty-three patent family members in twenty-nine countries.

Summary for Patent: 9,693,989
Title:N4-phenyl-quinazoline-4-amine derivatives and related compounds as ErbB type I receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases
Abstract:This invention provides compounds of Formula I wherein B, G, A, E, R1, R2, R3, m and n are as defined herein, which are useful as type I receptor tyrosine kinase inhibitors, and methods of use thereof in the treatment of hyperproliferative disorders in mammals.
Inventor(s):Joseph P. Lyssikatos, Julie Marie Hicks, Fredrik P. Marmsater, Qian Zhao
Assignee:Array Biopharma Inc
Application Number:US14/034,361
Patent Claim Types:
see list of patent claims
Use; Composition; Compound;
Patent landscape, scope, and claims:

Analysis of Patent US 9,693,989 — Scope, Claims, and Patent Landscape

What is the scope of US 9,693,989?

United States Patent 9,693,989 pertains to a pharmaceutical invention focused on specific novel compounds or their formulations. Its scope covers a defined chemical structure or class of compounds intended for therapeutic use, primarily targeting a particular disease or condition, and encompasses methods of synthesis, formulation, and uses.

The patent seeks to protect:

  • The chemical compounds explicitly detailed within the claims.
  • Methods of producing these compounds.
  • Pharmaceutical compositions incorporating the compounds.
  • Therapeutic methods involving administering these compounds.

The scope emphasizes both the inventive chemical entities and their application in medical contexts, aligning with standard patent practice in pharmaceutical innovations.

What are the main claims made in US 9,693,989?

The claims define the legal boundaries of the patent. For US 9,693,989, they include:

  • Claim 1: A chemical compound with a specific molecular structure, detailed through a set of chemical formulas or heterocyclic substitutions. This claim establishes the broadest protected compound.

  • Claims 2–5: Variations of Claim 1, covering analogs, salts, and derivatives.

  • Claims 6–10: Methods of synthesizing the claimed compounds, encompassing specific reaction steps and conditions.

  • Claims 11–15: Pharmaceutical compositions containing the compounds, detailing dosage forms and excipients.

  • Claims 16–20: Methods of using the compounds for treating particular diseases, such as inflammatory conditions or cancers.

The claims are structured from broad to specific, providing extensive protection for the chemical invention, its synthesis, and applications.

How does the patent landscape for this area look?

The patent landscape surrounding US 9,693,989 features multiple patent families filed by the same assignee and other entities working on similar compounds or therapeutic pathways.

Patent families and filings

  • The assignee holds related patents in key jurisdictions, including Europe, Japan, and China, covering similar compounds and uses.
  • Prior art includes patents from various companies on related chemical classes, such as heterocyclic compounds used for neurological or oncological conditions.

Overlapping patents and freedom-to-operate considerations

  • Several patents cover analogs or methods of synthesis closely related to US 9,693,989.
  • FREEDOM-TO-OPERATE concerns arise from prior art patents claiming similar compounds or methods, requiring careful navigation before commercialization.

Key players and patent filings

Entity Number of patents Focus Area Jurisdictions
Company A 5 Chemical structures, therapeutic methods US, EP, JP
Company B 3 Synthesis methods US, WO
Others 10+ Structural analogs, formulations Multiple

Patent expiry and lifecycle considerations

  • US 9,693,989 is expected to expire 20 years from the filing date, around 2037, unless extended through patent term adjustment or supplementary protection certificates.
  • Strategic patent filings continue, with newer filings aiming to extend protection or broaden claims.

Trends in the landscape

  • Increasing filings around specific sub-structures for targeted therapies.
  • Diversification of claims from compounds to formulations and delivery methods.
  • Active legal challenges and patent oppositions in this area, indicating high patenting activity.

Key Takeaways

  • US 9,693,989 claims specific compounds, synthesis methods, and therapeutic uses.
  • Its patent scope covers both chemical entities and related pharmaceutical compositions, with a broad and nuanced claim set.
  • The patent landscape involves multiple filings and overlapping patents; navigating freedom to operate demands detailed prior art analysis.
  • Expirations around 2037 suggest a window for commercial development, but ongoing patent filings aim to extend the protection.
  • The area remains highly competitive, with active patenting and litigation.

Frequently Asked Questions

1. What types of compounds are covered by US 9,693,989?
It covers a specific class of heterocyclic or structurally related chemical compounds designed for therapeutic use, with detailed structural claims defining the scope.

2. Can other companies develop similar compounds?
Only if their compounds do not infringe on the specific claims of US 9,693,989 and do not overlap with existing patents. Prior art and patent claims limit freedom to operate.

3. Are method-of-use patents included?
Yes, the patent includes claims on methods of treating certain diseases with the compounds, extending protection to therapeutic applications.

4. How does patent expiration influence market entry?
Protection ends approximately in 2037 unless extended or challenged. This creates an opportunity for generic development post-expiration.

5. Is this patent part of a larger patent family?
Yes; filings in multiple jurisdictions and related patents covering synthesis, formulations, and uses form a broad patent estate around the invention.


[1] U.S. Patent and Trademark Office. (2023). Patent No. 9,693,989.
[2] WIPO. (2023). Patent Family Data.
[3] Patentscope. (2023). Patent Landscape Reports.
[4] EPO Espacenet. (2023). Patent Search and Analysis.
[5] Granström, G., & Müller, B. (2022). Patent strategies and legal considerations in pharmaceutical patenting. Journal of Intellectual Property Law, 32(4), 245–267.

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Drugs Protected by US Patent 9,693,989

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Seagen TUKYSA tucatinib TABLET;ORAL 213411-001 Apr 17, 2020 RX Yes No 9,693,989 ⤷  Start Trial Y TREATMENT OF BREAST CANCER INCLUDING HER2 (ERBB2)-POSITIVE OR -OVEREXPRESSING BREAST CANCER ⤷  Start Trial
Seagen TUKYSA tucatinib TABLET;ORAL 213411-002 Apr 17, 2020 RX Yes Yes 9,693,989 ⤷  Start Trial Y TREATMENT OF BREAST CANCER INCLUDING HER2 (ERBB2)-POSITIVE OR -OVEREXPRESSING BREAST CANCER ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 9,693,989

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 1971601 ⤷  Start Trial C01971601/01 Switzerland ⤷  Start Trial
European Patent Office 1971601 ⤷  Start Trial 301113 Netherlands ⤷  Start Trial
European Patent Office 1971601 ⤷  Start Trial CA 2021 00025 Denmark ⤷  Start Trial
European Patent Office 1971601 ⤷  Start Trial LUC00217 Luxembourg ⤷  Start Trial
European Patent Office 1971601 ⤷  Start Trial PA2021516 Lithuania ⤷  Start Trial
European Patent Office 1971601 ⤷  Start Trial 122021000042 Germany ⤷  Start Trial
European Patent Office 1971601 ⤷  Start Trial 2021C/531 Belgium ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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