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Last Updated: March 29, 2024

Details for Patent: 9,649,306


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Summary for Patent: 9,649,306
Title:Treatment of diseases through administration of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2- -(tetrahydro-pyran-4-ylamino)-benzamide
Abstract: The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2- -(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention.
Inventor(s): Barbugian; Natale Alvaro (Milan, IT), Forino; Romualdo (Milan, IT), Fumagalli; Tiziano (Trezzano Rosa, IT), Orsini; Paolo (Legnano, IT)
Assignee: NERVIANO MEDICAL SCIENCES S.R.L. (Nerivano (MI), IT)
Application Number:15/172,478
Patent Claim Types:
see list of patent claims
Use; Composition;

Drugs Protected by US Patent 9,649,306

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Genentech Inc ROZLYTREK entrectinib CAPSULE;ORAL 212725-001 Aug 15, 2019 RX Yes No ⤷  Try a Trial ⤷  Try a Trial TREATMENT OF SOLID TUMORS THAT HAVE A NEUROTROPHIC TYROSINE RECEPTOR KINASE (NTRK) GENE FUSION ⤷  Try a Trial
Genentech Inc ROZLYTREK entrectinib CAPSULE;ORAL 212725-001 Aug 15, 2019 RX Yes No ⤷  Try a Trial ⤷  Try a Trial TREATMENT OF ROS1-POSITIVE NON-SMALL CELL LUNG CANCER ⤷  Try a Trial
Genentech Inc ROZLYTREK entrectinib CAPSULE;ORAL 212725-002 Aug 15, 2019 RX Yes Yes ⤷  Try a Trial ⤷  Try a Trial TREATMENT OF SOLID TUMORS THAT HAVE A NEUROTROPHIC TYROSINE RECEPTOR KINASE (NTRK) GENE FUSION ⤷  Try a Trial
Genentech Inc ROZLYTREK entrectinib CAPSULE;ORAL 212725-002 Aug 15, 2019 RX Yes Yes ⤷  Try a Trial ⤷  Try a Trial TREATMENT OF ROS1-POSITIVE NON-SMALL CELL LUNG CANCER ⤷  Try a Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 9,649,306

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
12169139May 23, 2012

International Family Members for US Patent 9,649,306

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina 091138 ⤷  Try a Trial
Australia 2013265288 ⤷  Try a Trial
Australia 2018201037 ⤷  Try a Trial
Brazil 112014028841 ⤷  Try a Trial
Canada 2873979 ⤷  Try a Trial
China 104395308 ⤷  Try a Trial
China 106167485 ⤷  Try a Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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