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Serving 500+ biopharmaceutical companies globally:

Chinese Patent Office
Express Scripts
Queensland Health
Dow
Deloitte
Boehringer Ingelheim
McKesson
Harvard Business School
McKinsey
Teva

Generated: August 23, 2017

DrugPatentWatch Database Preview

Details for Patent: ► Subscribe

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Which drugs does patent 9,181,257 protect, and when does it expire?


Patent ► Subscribe protects IMBRUVICA and is included in one NDA.

This patent has one hundred and six patent family members in twenty-six countries.

Summary for Patent: ► Subscribe

Title:Inhibitors of Bruton's tyrosine kinase
Abstract: Disclosed herein are pyrazolo[3,4-d]pyrimidines that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
Inventor(s): Honigberg; Lee (San Francisco, CA), Verner; Erik (Belmont, CA), Pan; Zhengying (Austin, TX)
Assignee: PHARMACYCLICS LLC (Sunnyvale, CA)
Application Number:14/080,640
Patent Claim Types:
see list of patent claims
Compound;

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Pharmacyclics Inc
IMBRUVICA
ibrutinib
CAPSULE;ORAL205552-001Nov 13, 2013RXYesYes► Subscribe► SubscribeYY
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Non-Orange Book Patents for Patent: ► Subscribe

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
8,759,516Inhibitors of Bruton's tyrosine kinase► Subscribe
8,476,284Inhibitors of Bruton's tyrosine kinase► Subscribe
8,563,563Inhibitors of bruton's tyrosine kinase► Subscribe
8,232,280Inhibitors of bruton'S tyrosine kinase► Subscribe
8,236,812Inhibitors of bruton's tyrosine kinase► Subscribe
8,957,079Inhibitors of Bruton's tyrosine kinase► Subscribe
8,748,438Inhibitors of Bruton's tyrosine kinase► Subscribe
7,514,444Inhibitors of bruton's tyrosine kinase► Subscribe
8,691,546Inhibitors of Bruton's tyrosine kinase► Subscribe
9,556,182Inhibitors of Bruton's tyrosine kinase► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Because of the complexity of determining patent expiration dates it is advisable to have patent counsel verify freedom to operate.

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International Patent Family for Patent: ► Subscribe

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria531263► Subscribe
Australia2006348662► Subscribe
Australia2008232762► Subscribe
Australia2010201052► Subscribe
Australia2012205166► Subscribe
BrazilPI0622054► Subscribe
BrazilPI0622277► Subscribe
BrazilPI0810086► Subscribe
Canada2663116► Subscribe
Canada2681756► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving 500+ biopharmaceutical companies globally:

Mallinckrodt
Moodys
US Department of Justice
Medtronic
Accenture
QuintilesIMS
Merck
Dow
Julphar
Cerilliant

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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