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Serving hundreds of leading biopharmaceutical companies globally:

Express Scripts
Fish and Richardson
Cipla
Fuji
Argus Health
Dow
US Army
Covington
Merck

Generated: May 22, 2018

DrugPatentWatch Database Preview

Details for Patent: 8,993,600

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Which drugs does patent 8,993,600 protect, and when does it expire?

Patent 8,993,600 protects ORKAMBI and is included in one NDA.

This patent has forty-nine patent family members in twenty-three countries.
Summary for Patent: 8,993,600
Title:Modulators of ATP-binding cassette transporters
Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Inventor(s): Hadida Ruah; Sara S. (La Jolla, CA), Hamilton; Matthew (Hackettstown, NJ), Miller; Mark (San Diego, CA), Grootenhuis; Peter D. J. (San Diego, CA), Bear; Brian (Oceanside, CA), McCartney; Jason (Cardiff by the Sea, CA), Zhou; Jinglan (San Diego, CA)
Assignee: Vertex Pharmaceuticals Incorporated (Boston, MA)
Application Number:12/114,935
Patent Claim Types:
see list of patent claims
Composition; Compound;

Drugs Protected by US Patent 8,993,600

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Vertex Pharms Inc ORKAMBI ivacaftor; lumacaftor TABLET;ORAL 206038-002 Sep 28, 2016 RX Yes No ➤ Sign Up ➤ Sign Up Y ➤ Sign Up
Vertex Pharms Inc ORKAMBI ivacaftor; lumacaftor TABLET;ORAL 206038-001 Jul 2, 2015 RX Yes Yes ➤ Sign Up ➤ Sign Up Y ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Non-Orange Book US Patents Family Members for Patent 8,993,600

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
8,318,733 Modulators of ATP-binding cassette transporters ➤ Sign Up
7,754,739 Modulators of CFTR ➤ Sign Up
7,659,268 Modulators of ATP-binding cassette transporters ➤ Sign Up
8,012,999 Modulators of CFTR ➤ Sign Up
Patent No. Title Estimated Patent Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Deloitte
Chubb
Teva
Moodys
Dow
Daiichi Sankyo
Johnson and Johnson
Citi
Chinese Patent Office

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