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Serving leading biopharmaceutical companies globally:

Colorcon
Argus Health
US Department of Justice
Deloitte
US Army
Citi
Chubb
Teva
Baxter
Merck

Generated: January 16, 2018

DrugPatentWatch Database Preview

Details for Patent: 8,449,909

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Summary for Patent: 8,449,909
Title:Abuse-deterrent drug formulations
Abstract: An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opiods. In the preferred embodiment, the drug is modified to increase its lipophilicity by forming a salt between the drug and one or more fatty acids wherein the concentration of the one or more fatty acids is one to 15 times the molar amount of the active agent, preferably two to ten times the molar amount of the active agent. In one embodiment the modified drug is homogeneously dispersed within microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and preferably organic solvent insoluble. The abuse-deterrent composition prevents the immediate release of a substantial portion of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is broken down or dissolved gradually within the GI tract by a combination of enzymatic degradation, surfactant action of bile acids, and mechanical erosion.
Inventor(s): Hirsh; Jane (Wellesley, MA), Fleming; Alison (Mansfield, MA), Rariy; Roman (Philadelphia, PA), Kilbanov; Alexander (Boston, MA)
Assignee: Collegium Pharmaceutical, Inc. (Canton, MA)
Application Number:12/823,628
Patent Claim Types:
see list of patent claims
Composition; Dosage form;

Drugs Protected by US Patent 8,449,909

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Collegium Pharm Inc XTAMPZA ER oxycodone CAPSULE, EXTENDED RELEASE;ORAL 208090-001 Apr 26, 2016 RX Yes No ➤ Subscribe ➤ Subscribe Y ➤ Subscribe
Collegium Pharm Inc XTAMPZA ER oxycodone CAPSULE, EXTENDED RELEASE;ORAL 208090-002 Apr 26, 2016 RX Yes No ➤ Subscribe ➤ Subscribe Y ➤ Subscribe
Collegium Pharm Inc XTAMPZA ER oxycodone CAPSULE, EXTENDED RELEASE;ORAL 208090-003 Apr 26, 2016 RX Yes No ➤ Subscribe ➤ Subscribe Y ➤ Subscribe
Collegium Pharm Inc XTAMPZA ER oxycodone CAPSULE, EXTENDED RELEASE;ORAL 208090-004 Apr 26, 2016 RX Yes No ➤ Subscribe ➤ Subscribe Y ➤ Subscribe
Collegium Pharm Inc XTAMPZA ER oxycodone CAPSULE, EXTENDED RELEASE;ORAL 208090-005 Apr 26, 2016 RX Yes Yes ➤ Subscribe ➤ Subscribe Y ➤ Subscribe
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Non-Orange Book US Patents Family Members for Patent 8,449,909

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
8,840,928 Tamper-resistant pharmaceutical compositions of opioids and other drugs ➤ Subscribe
7,399,488 Abuse-deterrent pharmaceutical compositions of opiods and other drugs ➤ Subscribe
9,592,200 Abuse-deterrent pharmaceutical compositions of opioids and other drugs ➤ Subscribe
7,771,707 Abuse-deterrent drug formulations ➤ Subscribe
9,044,398 Abuse-deterrent pharmaceutical compositions of opiods and other drugs ➤ Subscribe
8,758,813 Abuse-deterrent drug formulations ➤ Subscribe
8,557,291 Abuse-deterrent pharmaceutical compositions of opioids and other drugs ➤ Subscribe
9,763,883 Abuse-deterrent drug formulations ➤ Subscribe
9,248,195 Abuse-deterrent pharmaceutical compositions of opioids and other drugs ➤ Subscribe
9,682,075 Tamper-resistant pharmaceutical compositions of opioids and other drugs ➤ Subscribe
Patent No. Title Estimated Patent Expiration

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International Patents Family Members for US Patent 8,449,909

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Japan 2017101075 ➤ Subscribe
Japan 2015166402 ➤ Subscribe
Japan 2013216707 ➤ Subscribe
Japan 2009298822 ➤ Subscribe
Japan 4694207 ➤ Subscribe
Japan 2006500426 ➤ Subscribe
European Patent Office 1765292 ➤ Subscribe
European Patent Office 1594467 ➤ Subscribe
Canada 2916869 ➤ Subscribe
Canada 2569958 ➤ Subscribe
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving leading biopharmaceutical companies globally:

Chinese Patent Office
Mallinckrodt
Medtronic
QuintilesIMS
UBS
AstraZeneca
Cerilliant
Julphar
Farmers Insurance

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