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Serving leading biopharmaceutical companies globally:

Queensland Health
Colorcon
Mallinckrodt
Accenture
Chubb
Teva
AstraZeneca
Argus Health
Julphar
McKesson

Generated: January 17, 2018

DrugPatentWatch Database Preview

Details for Patent: 8,389,470

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Which drugs does patent 8,389,470 protect, and when does it expire?

Patent 8,389,470 protects AFREZZA and is included in one NDA.

This patent has fifty-eight patent family members in seventeen countries.
Summary for Patent: 8,389,470
Title:Methods and compositions for delivering peptides
Abstract: Methods are provided for purifying peptides and proteins by incorporating the peptide or protein into a diketopiperazine or competitive complexing agent to facilitate removal one or more impurities, from the peptide or protein. Formulations and methods also are provided for the improved transport of active agents across biological membranes, resulting for example in a rapid increase in blood agent concentration. The formulations include microparticles formed of (i) the active agent, which may be charged or neutral, and (ii) a transport enhancer that masks the charge of the agent and/or that forms hydrogen bonds with the target biological membrane in order to facilitate transport. In one embodiment, insulin is administered via the pulmonary delivery of microparticles comprising fumaryl diketopiperazine and insulin in its biologically active form. This method of delivering insulin results in a rapid increase in blood insulin concentration that is comparable to the increase resulting from intravenous delivery.
Inventor(s): Steiner; Solomon S. (Mount Kisco, NY), Woods; Rodney J. (New Hampton, NY), Sulner; Joseph W. (Paramus, NJ)
Assignee: MannKind Corporation (Valencia, CA)
Application Number:12/985,197
Patent Claim Types:
see list of patent claims
Composition; Compound; Use; Delivery;

Drugs Protected by US Patent 8,389,470

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Mannkind AFREZZA insulin recombinant human POWDER;INHALATION 022472-001 Jun 27, 2014 RX Yes No ➤ Subscribe ➤ Subscribe Y PULMONARY ADMINISTRATION OF A COMPOSITION COMPRISING INSULIN BOUND TO A COMPLEXING AGENT. ➤ Subscribe
Mannkind AFREZZA insulin recombinant human POWDER;INHALATION 022472-002 Jun 27, 2014 RX Yes Yes ➤ Subscribe ➤ Subscribe Y PULMONARY ADMINISTRATION OF A COMPOSITION COMPRISING INSULIN BOUND TO A COMPLEXING AGENT. ➤ Subscribe
Mannkind AFREZZA insulin recombinant human POWDER;INHALATION 022472-003 Apr 17, 2015 RX Yes No ➤ Subscribe ➤ Subscribe Y PULMONARY ADMINISTRATION OF A COMPOSITION COMPRISING INSULIN BOUND TO A COMPLEXING AGENT. ➤ Subscribe
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Non-Orange Book US Patents Family Members for Patent 8,389,470

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
7,943,572 Superior control of blood glucose in diabetes treatment ➤ Subscribe
6,444,226 Purification and stabilization of peptide and protein pharmaceutical agents ➤ Subscribe
9,801,925 Potentiation of glucose elimination ➤ Subscribe
6,652,885 Purification and stabilization of peptide and protein pharmaceutical agents ➤ Subscribe
8,889,099 Methods and compositions for delivering peptides ➤ Subscribe
7,943,178 Methods and compositions for delivering peptides ➤ Subscribe
7,648,960 Method for delivery of monomeric or dimeric insulin complexed to diketopiperazine microparticles ➤ Subscribe
9,006,175 Potentiation of glucose elimination ➤ Subscribe
Patent No. Title Estimated Patent Expiration

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International Patents Family Members for US Patent 8,389,470

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 411040 ➤ Subscribe
Austria 471154 ➤ Subscribe
Austria 545652 ➤ Subscribe
Australia 2005202230 ➤ Subscribe
Australia 2006230576 ➤ Subscribe
Australia 2008229952 ➤ Subscribe
Australia 2011200675 ➤ Subscribe
Australia 2012201760 ➤ Subscribe
Australia 2012203626 ➤ Subscribe
Australia 5901000 ➤ Subscribe
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving leading biopharmaceutical companies globally:

Baxter
Citi
UBS
Teva
Daiichi Sankyo
Novartis
Boehringer Ingelheim
Chubb
McKinsey

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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