Compounds and compositions as hedgehog pathway modulators
The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
Gao; Wenqi (San Diego, CA), Jiang; Jiqing (San Diego, CA), Wan; Yongqin (Irvine, CA), Cheng; Dai (San Diego, CA), Han; Dong (San Diego, CA), Wu; Xu (San Diego, CA), Pan; Shifeng (San Diego, CA)
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