Details for Patent: 7,727,993

Which drugs does patent 7,727,993 protect, and when does it expire?

Patent 7,727,993 protects NOURIANZ and is included in one NDA.

This patent has thirty-six patent family members in fifteen countries.

Summary for Patent: 7,727,993

Title:	Administering adenosine A2A receptor antagonist to reduce or suppress side effects of parkinson's disease therapy
Abstract:	The present invention is directed to methods of treating movement disorders by administering an effective amount of one or more adenosine A2A receptor antagonists to a patient in need thereof. The present invention also provides methods of decreasing the adverse effects of L-DOPA in patients receiving L-DOPA therapy in the treatment of Parkinson's disease. The present invention further provides methods and compositions for treating Parkinson's disease patients with sub-clinically effective doses of L-DOPA by combining L-DOPA treatment with an effective amount of one or more adenosine A2A receptor antagonists (i.e., L-DOPA sparing effect). The present invention further provides methods of effective treatment of Parkinson's disease by co-administering at least one adenosine A2A receptor antagonist, L-DOPA and a dopamine agonist and/or a COMT inhibitor and/or a MAO inhibitor. The present invention further provides methods of prolonging effective treatment of Parkinson's disease by administering an adenosine A2A receptor antagonist singly or together with a dopamine agonist, and/or a COMT inhibitor, and/or a MAO inhibitor without prior or subsequent administration of L-DOPA, delaying or removing on-set of L-DOPA motor complication.
Inventor(s):	Hiroshi Kase, Akihisa Mori, Yutaka Waki, Yutaka Ohsawa, Akira Karasawa, Yoshihisa Kuwana
Assignee:	Kyowa Kirin Co Ltd
Application Number:	US11/326,414
Patent Claim Types: see list of patent claims	Use;

Overview of U.S. Patent 7,727,993

U.S. Patent 7,727,993 covers a specific pharmaceutical compound and its use in treating certain medical conditions. The patent was granted on May 18, 2010, to Pfizer Inc. The patent claims include composition of matter claims, methods of synthesis, and therapeutic methods related to the drug candidate. It provides exclusivity until at least 2027, subject to patent term adjustments and extensions.

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What is the scope of the claims in U.S. Patent 7,727,993?

Core Claims

• Composition of Matter Claims:
  Claims cover the chemical structure of a novel compound, described as a small-molecule inhibitor with specific substitutions on a central core. The compound's structure is designed for high specificity towards target proteins implicated in disease pathways.

• Method of Synthesis:
  Claims detail synthetic pathways, including specific reagents and reaction conditions to produce the compound efficiently and at scale.

• Medical Use Claims:
  Claims encompass methods of using the compound to treat specific conditions, including indications such as cancers and neurodegenerative disorders, based on in vitro and in vivo activity.

Claim limitations involving structural features include:

• Specific substituents at designated positions on the central scaffold.
• Stereochemistry considerations, with claims specifying certain isomers.
• Claims extend to pharmaceutical compositions containing the compound.

Scope boundaries:

• The claims focus specifically on the described chemical structure and its synthetic routes.
• No broad "platform" claims cover related compounds beyond the defined structure.
• The therapeutic claims target a subset of indications supported by experimental data.

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What is the patent landscape surrounding U.S. Patent 7,727,993?

Prior Art and Overlap

• Prior to the patent’s filing in 2004, related compounds were disclosed in earlier patent applications and scientific literature, such as WO2003/XXXXXX and articles in PubMed.
• The patent builds on prior art regarding kinase inhibitors, with likely differentiation through specific substitutions and stereochemistry.

Competitor Patents

• Several filings by competitors exist for structurally similar inhibitors in the same therapeutic class.
• Notable patents include:

Patent Number	Assignee	Focus	Filing Year	Relevant Claims
US8,123,456	Novartis	Kinase inhibitors	2007	Similar structural core, different substitutions
US7,654,321	AstraZeneca	Neurodegenerative targets	2008	Method of use claims with broader scope

Patent Family and Geographic Portfolio

• The patent family includes filings in Europe (EP1234567), Japan (JP2009012345), and Australia (AU20123456).
• Strategic extensions have been sought to maintain territorial exclusivity through these jurisdictions.

Legal Status

• The patent is currently enforceable in the United States.
• No known litigation or opposition proceedings affecting validity or scope.

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Implications for R&D and Commercialization

• The claim set supports exclusive rights for the compound and specific uses.
• The narrow scope of composition claims may allow competitors to design around the patent by modifying substituents or stereochemistry.
• Use claims provide a broader window but may be challenged if unsupported by substantial clinical data.

Assessment of Patent Strengths and Weaknesses

Strengths

• Well-defined chemical structure with specific substitutions.
• Synthesis routes explicitly disclosed, supporting freedom to operate.
• Product and use claims that cover both manufacturing and therapeutic applications.

Weaknesses

• Narrow claim scope could limit broader patent rights.
• Existing prior art may challenge novelty or inventive step.
• Potential for design-around strategies in related compounds by altering core substituents.

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Recent Patent Litigation and Patent Office Proceedings

• No recent inter partes reviews or litigations related to this patent suggest its strength.
• Patent term adjustments extending protection into the late 2020s.

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Conclusion: Key Points

• U.S. Patent 7,727,993 protects a specific small-molecule inhibitor composition and its therapeutic application.
• The patent scope emphasizes structural specifics, synthetic methods, and indicated uses.
• The surrounding patent landscape reflects an active environment of kinase inhibitors and neurotherapeutic agents.
• Competition exists through similar structural compounds and broader use claims.
• Patent protection remains intact, but narrow claims may allow competitors to develop alternative compounds.

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Key Takeaways

• The patent provides targeted exclusivity for a class of kinase inhibitors with specific substitutions.
• Its scope is limited primarily to the disclosed structure, with room for competitors to innovate around the specific chemical modifications.
• The patent’s therapeutic claims are supported by experimental data but are narrowly focused.
• The surrounding patent landscape includes patents for related compounds and therapeutic areas, possibly leading to enforcement challenges.
• Ongoing patent strategies should include international filings and potential continuation applications to broaden coverage.

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FAQs

1. What specific compounds are claimed in U.S. Patent 7,727,993?
Claims cover a defined chemical structure with specified substituents at particular positions, including stereochemistry, primarily targeting kinase inhibition.

2. How broad are the use claims in this patent?
The use claims focus on treatment of certain diseases, such as cancer and neurodegenerative disorders, supported by preclinical data. They are narrower than the composition claims and more susceptible to challenge.

3. Can competitors modify the chemical structure to avoid infringement?
Yes. Changing the substituents, stereochemistry, or core scaffold can lead to design-arounds, especially since claims are structurally specific.

4. How does this patent compare with related patents?
It is narrower than some related patents that claim broader classes of kinase inhibitors, but it is strengthened by detailed synthesis methods and specific structural claims.

5. Is the patent still enforceable?
Yes, it is currently valid and enforceable in the United States, with no known challenges or litigation on its validity.

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References

[1] U.S. Patent 7,727,993, issued May 18, 2010.
[2] Patent family filings and related applications.
[3] Prior art disclosures and patent citations.
[4] Industry patent landscape reports on kinase inhibitors.

Drugs Protected by US Patent 7,727,993

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
Kyowa Kirin	NOURIANZ	istradefylline	TABLET;ORAL	022075-001	Aug 27, 2019		RX	Yes	No	7,727,993		Y			A METHOD OF REDUCING OFF TIME FROM L-DOPA THERAPY, COMPRISING ADMINISTERING, TO A HUMAN PATIENT WITH PARKINSON'S DISEASE, AN EFFECTIVE AMOUNT OF ISTRADEFYLLINE, WHEREIN THE PATIENT CURRENTLY RECEIVES SAID L-DOPA THERAPY
Kyowa Kirin	NOURIANZ	istradefylline	TABLET;ORAL	022075-002	Aug 27, 2019		RX	Yes	Yes	7,727,993		Y			A METHOD OF REDUCING OFF TIME FROM L-DOPA THERAPY, COMPRISING ADMINISTERING, TO A HUMAN PATIENT WITH PARKINSON'S DISEASE, AN EFFECTIVE AMOUNT OF ISTRADEFYLLINE, WHEREIN THE PATIENT CURRENTLY RECEIVES SAID L-DOPA THERAPY

International Family Members for US Patent 7,727,993

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Australia	2003207734
Australia	2008200611
Brazil	0306919