Heterocyclic compounds as inhibitors of beta-lactamases
This invention discloses and claims methods for inhibiting bacterial .beta.-lactamases and treating bacterial infections by inhibiting bacterial .beta.-lactamases in man or an animal comprising administering a therapeutically effective amount to said man or said animal of a compound, or pharmaceutically acceptable salt thereof, of formula (I) either alone or in combination with a .beta.-lactamine antibiotic wherein said combination can be administered separately, together or spaced out over time. Pharmaceutical compositions comprising a compound of formula (I), or a combination of a compound of formula (I) and a therapeutically effective amount of a .beta.-lactamine antibiotic, and a pharmaceutically acceptable carrier are also disclosed and claimed. ##STR00001##
Aszodi; Jozsef (Tucson, AZ), Fromentin; Claude (Paris, FR), Lampilas; Maxime (Saint Cloud, FR), Rowlands; David Alan (Poissy, FR)
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