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Details for Patent: 7,504,509

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Patent 7,504,509 protects ZELBORAF and is included in one NDA.

This patent has ten patent family members in twelve countries.

Summary for Patent: 7,504,509

Title:Compounds and methods for development of Ret modulators
Abstract: Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
Inventor(s): Ibrahim; Prabha (Mountain View, CA), Artis; Dean Richard (Kensington, CA), Bremer; Ryan (Albany, CA), Habets; Gaston (Pleasant Hill, CA), Hurt; Clarence R. (San Ramon, CA), Mamo; Shumeye (Oakland, CA), Nespi; Marika (Berkeley, CA), Zhang; Chao (Moraga, CA), Zhang; Jiazhong (Oakland, CA), Zhu; Yong (Union City, CA), Zuckerman; Rebecca (Alameda, CA), Krupka; Heike (Hayward, CA), Kumar; Abhinav (Pleasant Hill, CA), West; Brian (San Francisco, CA)
Assignee: Plexxikon, Inc. (Berkley, CA)
Application Number:11/016,350
Patent Claim Types:
see list of patent claims
Compound; Composition; Device;
Patent Metrics:
Source: PatentQuant.com
Field: Organic fine chemistry
Back Citations: 147th percentile
Forward Citations: 15th percentile

Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Hoffmann La Roche
ZELBORAF
vemurafenib
TABLET;ORAL202429-001Aug 17, 2011RXYes7,504,509► subscribeYY
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Non-Orange Book Patents for Patent: 7,504,509

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
8,067,434Compounds and methods for development of Ret modulators► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Because of the complexity of determining patent expiration dates it is advisable to have patent counsel verify freedom to operate.

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International Patent Family for Patent: 7,504,509

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia2004308299► subscribe
Canada2550361► subscribe
China1925855► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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