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Serving hundreds of leading biopharmaceutical companies globally:

Cerilliant
Medtronic
Johnson and Johnson
Cantor Fitzgerald
Fuji
Covington
Farmers Insurance
Colorcon
Baxter

Generated: April 25, 2018

DrugPatentWatch Database Preview

Details for Patent: 7,399,787

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Which drugs does patent 7,399,787 protect, and when does it expire?

Patent 7,399,787 protects ZOLINZA and is included in one NDA.

This patent has eighty-six patent family members in twenty-eight countries.
Summary for Patent: 7,399,787
Title:Methods of treating cancer with HDAC inhibitors
Abstract:The present invention provides methods of treating cancers, chemoprevention, selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by administration of pharmaceutical compositions comprising potent HDAC inhibitors. The oral bioavailability of the active compounds in the pharmaceutical compositions of the present invention is surprisingly high. Moreover, the pharmaceutical compositions unexpectedly give rise to high, therapeutically effective blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo.
Inventor(s): Chiao; Judy H. (Berkeley Heights, NJ), Bacopoulos; Nicholas G. (New York, NY), Miller; Thomas A. (New York, NY), Paradise; Carolyn M. (Cortland Manor, NY), Richon; Victoria M. (Rye, NY)
Assignee: Merck HDAC Research, LLC (Boston, MA)
Application Number:10/616,649
Patent Claim Types:
see list of patent claims
Use; Composition; Dosage form;

Drugs Protected by US Patent 7,399,787

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Merck ZOLINZA vorinostat CAPSULE;ORAL 021991-001 Oct 6, 2006 RX Yes Yes ➤ Try a Free Trial ➤ Try a Free Trial TREATMENT OF CUTANEOUS MANIFESTATIONS IN PATIENTS WTIH CUTANEOUS T-CELL LYMPHOMA (CTCL) ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Non-Orange Book US Patents Family Members for Patent 7,399,787

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
8,101,663 Polymorphs of suberoylanilide hydroxamic acid ➤ Try a Free Trial
7,851,509 Polymorphs of suberoylanilide hydroxamic acid ➤ Try a Free Trial
7,456,219 Polymorphs of suberoylanilide hydroxamic acid ➤ Try a Free Trial
7,652,069 Polymorphs of suberoylanilide hydroxamic acid ➤ Try a Free Trial
Patent No. Title Estimated Patent Expiration

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International Patents Family Members for US Patent 7,399,787

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 462426 ➤ Try a Free Trial
Australia 2003213684 ➤ Try a Free Trial
Australia 2004266169 ➤ Try a Free Trial
Australia 2004283717 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Deloitte
Merck
Colorcon
Chubb
Fuji
Daiichi Sankyo
Boehringer Ingelheim
Federal Trade Commission
Harvard Business School

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