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Serving leading biopharmaceutical companies globally:

Boehringer Ingelheim
Cantor Fitzgerald
Baxter
Moodys
QuintilesIMS
Harvard Business School
Deloitte
Mallinckrodt
McKesson
Cipla

Generated: February 25, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,739,116

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Summary for Patent: 5,739,116
Title: Enediyne derivatives useful for the synthesis of conjugates of methyltrithio antitumor agents
Abstract:This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.
Inventor(s): Hamann; Philip Ross (Garnerville, NY), Hinman; Lois (Tarrytown, NY), Hollander; Irwin (Monsey, NY), Holcomb; Ryan (Glen Rock, NJ), Hallett; William (New City, NY), Tsou; Hwei-Ru (New City, NY), Weiss; Martin J. (Ft. Lee, NJ)
Assignee: American Cyanamid Company (Madison, NJ)
Application Number:08/461,284
Patent Claim Types:
see list of patent claims
Compound;

Drugs Protected by US Patent 5,739,116

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 5,739,116

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Israel 129953 ➤ Sign Up
Canada 2150785 ➤ Sign Up
Cyprus 2334 ➤ Sign Up
Germany 69528016 ➤ Sign Up
Denmark 0689845 ➤ Sign Up
European Patent Office 0689845 ➤ Sign Up
Spain 2181752 ➤ Sign Up
Finland 952720 ➤ Sign Up
Finland 117690 ➤ Sign Up
Israel 113984 ➤ Sign Up
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Serving hundreds of leading biopharmaceutical companies globally:

Boehringer Ingelheim
Healthtrust
Harvard Business School
Chubb
Cerilliant
Julphar
Queensland Health
Citi
Colorcon

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