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Generated: December 11, 2017

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Details for Patent: 5,739,116

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Summary for Patent: 5,739,116

Title: Enediyne derivatives useful for the synthesis of conjugates of methyltrithio antitumor agents
Abstract:This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.
Inventor(s): Hamann; Philip Ross (Garnerville, NY), Hinman; Lois (Tarrytown, NY), Hollander; Irwin (Monsey, NY), Holcomb; Ryan (Glen Rock, NJ), Hallett; William (New City, NY), Tsou; Hwei-Ru (New City, NY), Weiss; Martin J. (Ft. Lee, NJ)
Assignee: American Cyanamid Company (Madison, NJ)
Application Number:08/461,284
Patent Claim Types:
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International Patent Family for Patent: 5,739,116

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Israel129953► Subscribe
Canada2150785► Subscribe
Cyprus2334► Subscribe
Germany69528016► Subscribe
Denmark0689845► Subscribe
European Patent Office0689845► Subscribe
Spain2181752► Subscribe
Finland952720► Subscribe
Finland117690► Subscribe
Israel113984► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

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