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Serving leading biopharmaceutical companies globally:

Cerilliant
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Medtronic
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Chubb
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Generated: January 17, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,693,762

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Summary for Patent: 5,693,762
Title: Humanized immunoglobulins
Abstract:Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immunoglobulin chain will usually comprise, in addition to the CDR's, amino acids from the donor immunoglobulin framework that are, e.g., capable of interacting with the CDR's to effect binding affinity, such as one or more amino acids which are immediately adjacent to a CDR in the donor immunoglobulin or those within about about 3 .ANG. as predicted by molecular modeling. The heavy and light chains may each be designed by using any one or all of various position criteria. When combined into an intact antibody, the humanized immunoglobulins of the present invention will be substantially non-immunogenic in humans and retain substantially the same affinity as the donor immunoglobulin to the antigen, such as a protein or other compound containing an epitope.
Inventor(s): Queen; Cary L. (Los Altos, CA), Co; Man Sung (Cupertino, CA), Schneider; William P. (Mountain View, CA), Landolfi; Nicholas F. (Milpitas, CA), Coelingh; Kathleen L. (San Francisco, CA), Selick; Harold E. (Belmont, CA)
Assignee: Protein Design Labs, Inc. (Mountain View, CA)
Application Number:08/487,200
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Drugs Protected by US Patent 5,693,762

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 5,693,762

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Spain 2081974 ➤ Subscribe
European Patent Office 1477497 ➤ Subscribe
European Patent Office 1491556 ➤ Subscribe
European Patent Office 2341080 ➤ Subscribe
Germany 122009000071 ➤ Subscribe
Germany 122007000037 ➤ Subscribe
European Patent Office 0939127 ➤ Subscribe C300692 Netherlands ➤ Subscribe
European Patent Office 0939127 ➤ Subscribe C300693 Netherlands ➤ Subscribe
Spain 2136760 ➤ Subscribe
Germany 122006000036 ➤ Subscribe
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving leading biopharmaceutical companies globally:

Teva
Farmers Insurance
McKinsey
Fish and Richardson
Cipla
Queensland Health
Julphar
Johnson and Johnson
US Army

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