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Details for Patent: 5,693,762

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Summary for Patent: 5,693,762

Title: Humanized immunoglobulins
Abstract:Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immunoglobulin chain will usually comprise, in addition to the CDR's, amino acids from the donor immunoglobulin framework that are, e.g., capable of interacting with the CDR's to effect binding affinity, such as one or more amino acids which are immediately adjacent to a CDR in the donor immunoglobulin or those within about about 3 .ANG. as predicted by molecular modeling. The heavy and light chains may each be designed by using any one or all of various position criteria. When combined into an intact antibody, the humanized immunoglobulins of the present invention will be substantially non-immunogenic in humans and retain substantially the same affinity as the donor immunoglobulin to the antigen, such as a protein or other compound containing an epitope.
Inventor(s): Queen; Cary L. (Los Altos, CA), Co; Man Sung (Cupertino, CA), Schneider; William P. (Mountain View, CA), Landolfi; Nicholas F. (Milpitas, CA), Coelingh; Kathleen L. (San Francisco, CA), Selick; Harold E. (Belmont, CA)
Assignee: Protein Design Labs, Inc. (Mountain View, CA)
Application Number:08/487,200
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

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International Patent Family for Patent: 5,693,762

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria133452► subscribe
Austria183753► subscribe
Austria251639► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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