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Serving hundreds of leading biopharmaceutical companies globally:

Citi
Harvard Business School
Julphar
Farmers Insurance
Medtronic
Daiichi Sankyo
Merck
AstraZeneca
Johnson and Johnson

Generated: May 26, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,585,089

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Summary for Patent: 5,585,089
Title: Humanized immunoglobulins
Abstract:Novel methods for producing, and compositions of humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immunoglobulin chain will usually comprise, in addition to the CDR's, amino acids from the donor immunoglobulin framework that are, e.g., capable of interacting with the CDR's to effect binding affinity, such as one or more amino acids which are immediately adjacent to a CDR in the donor immunoglobulin or those within about 3 .ANG. as predicted by molecular modeling. The heavy and light chains may each be designed by using any one or all of various position criteria. When combined into an intact antibody, the humanized immunoglobulins of the present invention will be substantially non-immunogenic in humans and retain substantially the same affinity as the donor immunoglobulin to the antigen, such as a protein or other compound containing an epitope.
Inventor(s): Queen; Cary L. (Los Altos, CA), Selick; Harold E. (Belmont, CA)
Assignee: Protein Design Labs, Inc. (Mountain View, CA)
Application Number:08/477,728
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 5,585,089
Patent Claim Types:
see list of patent claims
Compound; Composition;

Drugs Protected by US Patent 5,585,089

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Serving hundreds of leading biopharmaceutical companies globally:

Daiichi Sankyo
Queensland Health
Fish and Richardson
Baxter
Cantor Fitzgerald
UBS
Dow
Boehringer Ingelheim
Cerilliant

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