|Abstract:||A hirudin derivative which has the N-terminal amino acid sequence Leu-Thr-Tyr-Thr-Asp shows high biological activity. Moreover, this hirudin derivative can be obtained very efficiently by genetic engineering preparation in yeasts.|
|Inventor(s):||Crause; Peter (Offenbach, DE), Habermann; Paul (Frankfurt am Main, DE), Tripier; Dominique (Eppstein/Taunus, DE)|
|Assignee:||Hoechst Aktiengesellschaft (Frankfurt am Main, DE)|
Patent Claim Types:|
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|Foriegn Application Priority Data|
|Foreign Country||Foreign Patent Number||Foreign Patent Date|
|Germany||3805540||Feb 23, 1988|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
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